Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Sept. 22

My best home run predictions today feature Ronald Acuna Jr., Willy Adames, Jurickson Profar, and Christian Yelich.
Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Sept. 22
Pictured: Willy Adames against the Arizona Diamondbacks at Chase Field. Photo by Mark J. Rebilas via Imagn Images

With just six teams in action on Monday’s MLB slate, I had to get creative and double up on one of the games to comprise our best home run predictions today.

I am backing four sluggers in favorable matchups, while doubling up my MLB picks on one of the National League’s hottest offenses. 

My top home run bets today include Ronald Acuna Jr. and Jurickson Profar from the Atlanta Braves, along with Willy Adames and Christian Yelich. If all of them go yard, my four-leg $10 parlay would net over $10,000 in profits.


💰 MLB best home run predictions & odds today: Sept. 22

Best home run predictions today based on the latest MLB odds.

  • Ronald Acuna Jr. to hit a home run (+410 via DraftKings) ⭐⭐
  • Jurickson Profar to hit a home run (+600 via DraftKings) ⭐⭐⭐
  • Christian Yelich to hit a home run (+591 via DraftKings) ⭐⭐⭐
  • Willy Adames to hit a home run (+520 via DraftKings) ⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.

⚾ Jurickson Profar (Braves) to hit a home run ⭐⭐⭐

Home Run Predictions Today: Best MLB Odds, Picks & Prop Bets for Sept. 22
Pictured: Jurickson Profar hits an RBI single against the Detroit Tigers. Photo by Rick Osentoski via Imagn Images

Atlanta has been out of contention for most of the season, but it would have been interesting to see where it would have ended had Profar not been suspended for 80 games.

Profar’s 1.026 OPS in August was the fourth-highest among the 227 batters who had at least 75 plate appearances. He slashed .295/.428/.598, and was the first Braves player with 25-plus runs and at least 25 RBI in a month since 2003.

Profar entered Sunday with a respectable .824 OPS and four home runs over the last 30 days. And his home run odds get a considerable boost when facing Washington Nationals southpaw Mitchell Parker, who is one of 20 MLB pitchers to allow at least 25 home runs this season.

Parker has allowed 19 of his 25 home runs to right-handed batters, and his 1.56 HR/9 rate through 13 road starts is worse than his 1.33 HR/9 rate through 17 starts at home this season.

The Braves have tagged Parker for 13 earned runs in 15 innings this season, and the southpaw has allowed at least one home run in nine consecutive starts, with multiple home runs allowed three times in that span.

That makes these 14.29% implied odds for this wager seem like a steal, and a winning $10 wager at DraftKings would net $60.

📊 Nationals vs. Braves odds


🚀 Best home run parlay picks

Use our parlay calculator to get the best odds for any parlay.

  • Ronald Acuna Jr. to hit a home run (+390 via FanDuel)
  • Jurickson Profar to hit a home run (+560 via FanDuel)
  • Christian Yelich to hit a home run (+480 via FanDuel)
  • Willy Adames to hit a home run (+480 via FanDuel)

Parlay odds: +108692 via FanDuel ($10 to win $10,869.18)


❓ Best home run predictions FAQs

What are the best home run props for tonight?

My best home run predictions today feature Ronald Acuna Jr. (+410), Willy Adames (+520), Jurickson Profar (+600), and Christian Yelich (+591). 

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet? 

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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