Astros vs. Tigers Prediction, Odds & Best Bets: Brown, Skubal Put on Pitching Clinic

Last Updated: August 19, 2025 10:02 AM EDT • 3 minute read X Social Google News Link

Detroit demolished Houston in the series opener, but my Astros vs. Tigers prediction expects the visitors to force a decisive rubber match on Wednesday with a victory over Tarik Skubal and Co. tonight.
First pitch is scheduled for 6:40 p.m. ET (TBS) from Comerica Park in Detroit. The best MLB betting sites list the Tigers as -159 betting favorites, with a total set at O/U 7.5 runs.
My Astros vs. Tigers best bets believe Jose Altuve will improve upon his solid career stats against Detroit's ace and help power Houston to an unexpected victory on the road.
⚾ Astros vs. Tigers prediction & odds
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💰 Astros vs. Tigers prediction & best bet
✅ Astros vs. Tigers prediction: Astros to win (+145 via BetMGM)
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My Astros vs. Tigers prediction backs the betting underdogs due to their hilariously predictable nature. What do I mean by that, exactly? While many view Houston as Schrodinger's baseball team, its results are often straightforward. Long story short, the Astros play to the level of their competition, struggling against the bottom-dwellers while soaring against the contenders.
There is no better example of this theory than Houston mashing Cy Young Award odds contender Garrett Crochet for five runs, only to turn around and allow Brandon Young (0-6, 6.70 ERA before his start) to take a perfect game into the eighth inning in the same week.
Jack Flaherty (7-12, 4.51 ERA) dominated Houston hitters in Detroit's series-opening 10-0 victory. As such, Tigers fans should feel confident with baseball's best pitcher, Skubal (11-3, 2.42 ERA), on the bump tonight, right? Wrong. This is exactly where the visitors thrive. The Astros are 12-4 this season against current division leaders and 14-14 against last-place teams.
While Skubal has undeniably been the class of the league over the past two seasons, Brown has also been stellar. My Astros vs. Tigers best bet believes Brown can lead these inexplicably streaky bats to victory on the road tonight. BetMGM offers the most value among the best sports betting sites, with a $10 winning flier on the underdogs returning $14.50.

📊 Live Astros vs. Tigers odds: Tuesday, 6:40 p.m. ET
💰 Best Astros vs. Tigers player prop
✅ Best Astros vs. Tigers player prop: Jose Altuve 2+ total bases (+160 via FanDuel)
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Altuve is one of the best hitters in the modern era - argue with a wall. He's the poster child for mashing All-Star pitching, and his .357 career average (5-for-14) against Skubal is a microcosm of this. Three of those hits have gone for extra bases, including one home run against the MLB MVP odds long shot.
My best Astros vs. Tigers player prop expects the future Hall of Famer to record two-plus total bases tonight. His aforementioned history against Skubal plays a part, but so does the fact that even amid his mini-slump, Altuve has cleared this line at a 40% clip over his last 10 starts.
Seldom do Houston's bats get hot when Altuve isn't involved. If the Astros are going to jump on Skubal, the rally will likely start with Altuve. The best sports betting apps list the polarizing player at plus money (+160) to record two-plus bases tonight.
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