Penn State vs. Clemson Predictions & Odds | 2025 Pinstripe Bowl Best Bet & TD Pick
There might not be a game this bowl season that has more NFL talent sitting on the sidelines than the Pinstripe Bowl, but my Penn State vs. Clemson predictions highlight which team is better built to handle the adversity.
Clemson is a 3-point betting favorite for today's Noon ET (ABC) Pinstripe Bowl from Yankee Stadium in Bronx, N.Y., in the the 10th bowl game featured in our college football predictions this week.
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🏈 Penn State vs. Clemson predictions: 2025 Pinstripe Bowl
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💰 Penn State vs. Clemson best bet
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Clemson -2.5 (-110) ⭐⭐⭐
Neither of these programs is anywhere near full strength due to injuries, opt-outs, and transfer portal defections, but unlike Penn State, Clemson has its head coach and starting QB. With Dabo Swinney on the sideline and Cade Klubnik behind center, the Tigers are 3-1 ATS in their last four.
🚨 More missing starters than the Yankees have World Series wins
The New York Yankees have 27 World Series wins. The Pinstripe Bowl could be missing more than 30 players who have started for Clemson and Penn State this season. While there's a good chance we won't know every player missing the Pinstripe Bowl until kickoff, we do already know several stars set to miss the game.
The biggest names not taking the field for Penn State include Nicholas Singleton, Vega Ioane, Zane Durant, and Zakee Wheatley. The stars Clemson will be without include Peter Woods, TJ Parker, Antonio Williams, and Avieon Terrell.
Clemson also has a deeper bullpen of playmakers and shouldn't have more opt-outs, while Penn State interim head coach Terry Smith has implied several starters could see limited time.
If Penn State doesn't have star running back Kaytron Allen handling a full workload, generating offense will be tough.
Score prediction: Clemson 27, Penn State 23
🙌 Best Penn State vs. Clemson touchdown pick: Pinstripe Bowl
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Adam Randall, RB, Clemson: 2+ TDs (+225) ⭐⭐⭐
A lot hasn't gone right for Clemson this season, but moving former blue-chip recruit Adam Randall from wide receiver to running back paid off for Swinney's staff, especially late in the season.
The 6-foot-2, 230-pound Randall has been at his best since November, averaging 19 touches for 100 yards in Clemson's last four games against Power Four opponents. That includes two multi-touchdown games against Duke and Louisville.
With wide receivers Antonio Williams and Bryant Wesco Jr. set to miss the bowl game, Randall should continue to see major usage. He leads the team in touches (188), yards from scrimmage (1,025), and TDs (12).
Randall is one of just six players from the ACC with over 500 rushing yards after contact and more than 22 runs of 10-plus yards this season. That physicality and explosion should come in handy against a depleted Penn State defense.
📝 Top NFL draft prospects for Pinstripe Bowl
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| Player | Position | Key stats | NFL draft grade |
|---|---|---|---|
| Dani Dennis-Sutton, Penn State | EDGE | 10 TFLs, 6.5 sacks | Round 3-4 |
| Kaytron Allen, Penn State | RB | 1,303 rushing yards, 15 TDs | Round 4-5 |
| Blake Miller, Clemson | OT | 2 sacks, 16 pressures allowed | Round 4-5 |
| Drew Shelton, Penn State | OT | 1 sack, 19 pressures allowed | Round 4-6 |
| Cade Klubnik, Clemson | QB | 20 total TDs | Round 6-7 |
| Adam Randall, Clemson | RB | 1,025 scrimmage yards, 12 TDs | Round 6-7 |
📊 Live Penn State vs. Clemson odds: Pinstripe Bowl
Penn State vs. Clemson opening odds
- Moneyline: Penn State +160 | Clemson -190
- Spread: Penn State +4.5 (-110) | Clemson -4.5 (-110)
- Over/Under: Over 48.5 (-110) | Under 48.5 (-110)
📈 Penn State vs. Clemson betting trends
| Penn State | Statistic | Clemson |
|---|---|---|
| 6-6 | W-L record | 7-5 |
| 4-8 | ATS record | 5-7 |
| 8-3-1 | O/U record | 5-7 |
| 5.8 | Yards per play | 5.9 |
| 5.3 | Yards allowed per play | 5.3 |
| +0.3 | Turnover margin | +0.1 |
| 3-2 | Last 5 games | 4-1 |
| W, 40-36 vs. Rutgers | Previous result | W, 28-14 vs. South Carolina |
📺 How to watch Penn State vs. Clemson: Pinstripe Bowl
- Date: Saturday, Dec. 27
- Kickoff: Noon ET
- Location: Yankee Stadium (Bronx, N.Y.)
- TV: ABC
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