Ole Miss vs. Oklahoma Prediction & Odds Week 9: College Football Picks and Preview

Our early Ole Miss vs. Oklahoma prediction breaks down the best odds and picks for Week 9, with Oklahoma opening as a 4.5-point home favorite.
Ole Miss vs. Oklahoma Prediction & Odds Week 9: College Football Picks and Preview
Pictured: Ole Miss quarterback Trinidad Chambliss runs the ball against Georgia. Photo by Brett Davis via Imagn Images.

My Ole Miss vs. Oklahoma prediction and college football picks dive into the opening odds that project the Rebels to lose a second straight road game this weekend.

The action for Ole Miss vs. Oklahoma kicks off from Memorial Stadium in Norman, Okla., on Saturday at noon ET (ABC). And while Oklahoma is a 4.5-point betting favorite, my college football predictions for Week 9 back the road dog.


🏈 Ole Miss vs. Oklahoma prediction & betting preview

Stay ahead with the rest of our early college football predictions for Week 9.

🦈 Ole Miss +4.5 (-105) ⭐⭐⭐⭐

Oklahoma ranks sixth in adjusted defensive efficiency (AdjD), per ESPN’s Football Power Index, but the Sooners haven’t faced a top-20 offense in adjusted efficiency (AdjO) yet. That’s a realization that may slowly dawn on our best college football betting sites as the week unfolds.

Ole Miss checks in at No. 11 in AdjO after putting up 35 points on the road at Georgia in Week 8. The Rebels average 37.4 PPG, meaning it won’t be easy for the Sooners (40th in AdjO) to pull away from an explosive Ole Miss offense.

Lane Kiffin apologized to Ole Miss bettors after losing the cover on a late field goal at Kentucky last month. His awareness of the point spread can’t hurt the chances for a backdoor cover in the event of the Rebels trailing late.

At publish time, FanDuel offers the best odds (-105) on Ole Miss +4.5. The implied probability at those odds is 51.22%. A winning $10 bet would profit $9.52.

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📊 Ole Miss vs. Oklahoma odds: Week 9

Latest college football odds updated live in real time.

📈 Ole Miss vs. Oklahoma opening odds

  • Moneyline: Ole Miss +150 | Oklahoma -185
  • Spread: Ole Miss +4.5 (-110) | Oklahoma -4.5 (-110)
  • Over/Under: Over 51.5 (-110) | Under 51.5 (-110)

💡 Ole Miss vs. Oklahoma odds analysis

After the spread opened at Ole Miss +4.5 with -110 odds, our matchup page indicates that line has held with slight odds movement in either direction at all of our best sports betting sites, other than DraftKings, which has moved the line to Ole Miss +4.

Barring unforeseen news of significance on the injury front for either side, I would be surprised to see Oklahoma fall below -3 on the spread. But I could envision some movement toward the Rebels throughout the week as bettors realize that Oklahoma’s acclaimed defense still hasn’t faced an offense near the caliber of Ole Miss.


📺 How to watch Ole Miss vs. Oklahoma

  • When: Saturday, Oct. 25
  • Kickoff: Noon ET
  • Where: Memorial Stadium (Norman, Okla.)
  • TV: ABC

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