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Fulham's Aleksandar Mitrovic pulls down Newcastle's Kieran Trippier.
Fulham's Aleksandar Mitrovic pulls down Newcastle's Kieran Trippier. Photo by Malcolm Mackenzie/Gigi Soldano/DPPI via AFP.

There are some big matches this weekend, as the Premier League enters the second half of the season. Liverpool and Chelsea will be aiming to get their seasons on track in their Saturday showdown, while Arsenal can boost their title hopes with victory over Manchester United in north London. Check out our Premier League best bets. 

United’s winning streak ended in the capital on Wednesday, drawing 1-1 at Crystal Palace. Along with Arsenal and Brentford, the Red Devils are the Premier League’s in-form team. All three clubs have taken 13 points from the last 15 available, so something will have to give between the Gunners and United on Sunday. There are still plenty of games for the chasing pack to make up ground on Arsenal, but a win against a top four side like United will improve their chances of clinching the title. 

There’s a massive game involving two teams in the bottom three on Saturday, as West Ham host Everton. Both sides have the worst form in the competition heading into this fixture. Neither team has won in their last five, and both sides have taken just one point from a possible 15. The losing team from this match could see themselves four points from safety by the end of the day. 

Here are our best Premier League bets for Matchday 21 (odds via DraftKings Sportsbook, FanDuel SportsBook, PointsBet, and Caesars Sportsbook; pick confidence based on a 1-to-5-star scale).

Check out our Premier League best bets.

Matchday 21 Premier League Schedule and Odds

(Odds via FanDuel)

  • Liverpool (-120) vs. Chelsea (+310)
  • Bournemouth (+170) vs. Nottingham Forest (+170)
  • West Ham (-135) vs. Everton (+390)
  • Crystal Palace (+350) vs. Newcastle (-115)
  • Arsenal (-115) vs. Manchester United (+300)
  • Fulham (+220) vs. Tottenham (+110)

Matchday 21 Premier League Best Bets

  • Spread: Newcastle -1 (+165 via DraftKings) vs. Crystal Palace
  • Moneyline: Brentford (+190 via FanDuel) vs. Leeds
  • Total: West Ham-Everton Under 2.5 (-125 via Caesars)
  • Upset: Manchester United (+310 via DraftKings) vs. Arsenal

Matchday 21 Premier League Top Picks

Spread: Newcastle -1 vs. Crystal Palace (+165 via DraftKings) ⭐⭐⭐

Palace had a big comeback in midweek, scoring late in their 1-1 draw with Manchester United. Newcastle United head to Selhurst Park with the Premier League’s best defense. The Magpies haven’t conceded a goal in any of their last five league games. Palace have struggled scoring this season. Only five teams have scored fewer goals than the Eagles (18) in the competition. 

Patrick Vieira’s side have lost two and drawn one of their last three games. Newcastle are unbeaten in their last 14 Premier League matches, so Palace will find it difficult to break down this disciplined United team. The Toon can score and keep it tight in the back, which makes this handicap an appealing play. 

DraftKings is the only sportsbook that’s offering the spread at -1. Every other book is handicapping Newcastle at -0.5. That short play comes with a top price of -115 at Caesars. We’ll take the juice with the extra half goal. I’m confident United will win this match, but the long trip to southeast London is the only reason why I’m not giving this pick four stars. Newcastle have had a longer break though, which works to their advantage. 

Moneyline: Brentford ML vs. Leeds (+190 via FanDuel) ⭐⭐⭐⭐

Brentford are flying in the league right now. They’re unbeaten in their last five games, winning four. Their draw during that span was against Tottenham, and they beat Liverpool convincingly. 

Leeds beat Cardiff City in the FA Cup on Wednesday, but their league form has been poor. They’ve taken two points from a possible 15 in their last five matches. Since the start of last season, Leeds have conceded more Premier League goals than any other side (112), while only Everton (54) have won fewer points than the Whites among the 17 sides that have remained in the competition across the two campaigns (55).

Leeds are a slight favorite at home, despite their poor form. Three of our main sportsbooks have Brentford priced at +190. The Bees have scored multiple goals in every league game they’ve played since the World Cup. They’re one of the hot teams right now, which is why I believe they’re worth a four-star play. On form alone, they’re the superior side heading into this match. 

Total: West Ham-Everton Under 2.5 (-125 via Caesars) ⭐⭐⭐

Both teams have each scored 15 goals this season. Only the Wolves (12) have scored fewer goals in the competition. This is going to be a relegation scrap that neither team can afford to lose. 

If there’s a game that screams 0-0, this is it. Expect both teams to defend for their lives and risk very little going forward. For either side to win it could come down to a mistake, with the winner taking it 1-0. 

The value for this play varies. The books don’t expect many goals, which is why the best price we can find is -125 at Caesars. Although I think goals will be sparse, an early score for either side could open this match up with so much at stake, which is why it’s a three-star play.

Upset: Manchester United ML vs. Arsenal (+310 via DraftKings) ⭐⭐⭐

It doesn’t feel right calling the mighty Manchester United an upset, but they are the underdogs in this match. The Red Devils travel to London to face the league leaders. Arsenal were the league leaders when United beat them 3-1 at Old Trafford in September. 

Both sides enter this game in excellent form. Casermiro’s booking on Wednesday means that he will be suspended for this match, but manager Erik ten Hag believes his team can win despite the Brazilian’s absence. 

Marcus Rashford has been involved in eight goals in his 10 Premier League starts against Arsenal (four goals, four assists).

Arsenal have excelled so far this season. Victories from these fixtures will certify their championship status. However, United have quality throughout their side. It’s quality that beat Manchester City last week and, despite their midweek blip, it’s why I believe they can provide an upset on Sunday. 

Most of the books are unanimous in pricing United at +300. DraftKings offers the extra juice at +310. Manchester United are the road team at the league leaders, which is why I can’t give this play the four-star treatment. 

Premier League best bets made 01/19/2023 at 2 p.m. ET.

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