Real Madrid vs. Juventus Prediction Today: Champions League Odds, Expert Picks & Best Bets

Last Updated: October 22, 2025 1:25 PM EDT • 3 minute read X Social Google News Link

My Real Madrid vs. Juventus prediction today backs the favored home side to get a victory in the Spanish capital. Kickoff is at 3 p.m. ET today (Paramount+) from Santiago Bernabeu in Madrid.
Real Madrid is a -220 moneyline betting favorite, but I'm focusing my Champions League best bets on both teams to score and Juventus' Jonathan David to find the back of the net.
⚽ Real Madrid vs. Juventus predictions
Soccer picks odds subject to change.
- Game pick: Real Madrid ML (-220 via DraftKings) ⭐⭐⭐⭐⭐
- Over/Under pick: Over 2.5 (-170 via Caesars) ⭐⭐⭐⭐⭐
- Player prop pick: Jonathan David anytime goalscorer (+260 via FanDuel) ⭐⭐⭐⭐⭐
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✅ Real Madrid vs. Juventus expert pick today
⚽ Both teams to score (-130) ⭐⭐⭐⭐⭐
It’s been a great start to the season for Real Madrid. They’re top of La Liga and are perfect in the league phase of the Champions League after winning their first two games. Madrid’s attacking power has been a major reason for their success, with Kylian Mbappe leading the star-studded team with 15 goals in 11 games in all competitions. They shouldn’t have issues scoring.
Madrid have been solid defensively, too, but recent injuries could be about to derail their season. Madrid will be down five fit defenders for today's contest after injured David Alaba joined Dean Huijsen, Dani Carvajal, and Trent Alexander-Arnold in the team’s treatment room.
The injury crisis at Madrid could potentially open the door for Juventus to break out of their slump. While it’s going to be difficult for Juventus to win - even with the defensive advantage - I expect the Italian side to join Madrid in scoring a goal and possibly securing a point. A $10 bet on both teams scoring at Caesars pays a profit of $7.70 on -130 odds.
💰 Best Real Madrid vs. Juventus player prop bet
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🔥 Jonathan David anytime scorer (+260) ⭐⭐⭐⭐⭐
Juventus are without a win in their last six games. But Jonathan David should give them something to cheer about in their trip to the Spanish capital to play Real Madrid.
The Canadian forward will be integral to Juventus if the Serie A club has any hope of leaving Spain with a point. Expect him to record a long-overdue goal against Madrid.
David only has one goal - scored in August - and an assist since his big summer transfer from Lille. Opportunities to score have been a huge problem: David has registered only two shots in two Champions League appearances, and he has failed to take a shot in his last five domestic games.
But I’m expecting things to turn around and for David to get numerous chances to score whenever Real Madrid’s defense is left vulnerable after they press up the pitch, where turnovers could lead to goals. A winning $10 bet at FanDuel will net a profit of $26 if David scores.
📊 Real Madrid vs. Juventus odds today
Champions League odds updated live in real time.
📺 How to watch Real Madrid vs. Juventus
- Date: Wednesday, Oct. 22
- Kickoff: 3 p.m. ET
- Where: Santiago Bernabeu (Madrid)
- TV: Paramount+
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Gordon Brunt