Manchester United vs. Chelsea Prediction, Odds & Expert Picks: Premier League Matchweek 5 Best Bets

My Manchester United vs. Chelsea prediction backs the visitors to snatch victory (+150), thanks to a goal from the in-form Cole Palmer.
Manchester United vs. Chelsea Prediction, Odds & Expert Picks: Premier League Matchweek 5 Best Bets
Pictured: Moises Caicedo against Brentford in the Premier League. Photo by Harvey Murphy via Imagn Images.

My Manchester United vs. Chelsea prediction for Saturday's match at Old Trafford (12:30 p.m. ET, USA Network) analyzes the chances of the visitors breaking their 13-year winless streak in Manchester.  

Chelsea is the marginal +150 betting favorite as I offer the soccer picks below, also featuring a Cole Palmer prop bet. 


⚽ Manchester United vs. Chelsea prediction

Soccer picks odds subject to change.

  • Moneyline pick: Chelsea (+150 via FanDuel) ⭐⭐⭐
  • Against the spread pick: Chelsea -0.5 (+135 via DraftKings) ⭐⭐⭐
  • Over/Under pick: Over 2.5 (-160 via Caesars) ⭐⭐⭐

📝 Manchester United vs. Chelsea best bet

🔵 Chelsea to win (+150) ⭐⭐⭐

Chelsea hasn't won at Old Trafford in 13 years, which you'd presume doesn't bode well for the visitors. However, I envision the stars finally aligning on Saturday for the London club, thanks primarily to Manchester United's ghastly form to start the season. 

Ruben Amorim's job is in jeopardy, and rightly so. While I'm not suggesting the locker room has quit on him, something is severely wrong with United. Then again, things haven't been right on the red side of Manchester since I can remember.

The Red Devils lost one of two home matches thus far and were lucky to escape with a win against newly promoted side Burnley after scoring on a penalty at the death. That was their only win in four top-flight matches thus far, with last week's 3-0 derby loss to Man City the most worrying of the lot.

Chelsea hasn't been brilliant by any stretch of the imagination, but it has shown glimpses.

Had it not been for a careless lapse in concentration in the 93rd minute at Gtech Community Stadium, Enzo Maresca's side would have taken all three points against Brentford last week. 

And the Blues have Moises Caicedo in the heart of midfield. Not only has the 23-year-old made significant strides recently, but he has won five times in the eight matches he's played against United. 

Of the best sports betting sites, FanDuel offers the best value. Its +150 odds will yield a $15 profit on a $10 winning wager. 


💰 Best Manchester United vs. Chelsea player prop bet

🔥 Cole Palmer goal (+175) ⭐⭐⭐

Manchester United vs. Chelsea Prediction, Odds & Expert Picks: Premier League Matchweek 5 Best Bets
Pictured: Cole Palmer in action against Bayern Munich in the Champions League. Photo via Imagn Images.

Palmer has four goals in five matches against Manchester United, but he hasn't bagged one in the previous two. That's okay, though, as he has scored two goals in as many matches since returning from a recent groin injury.

The 23-year-old scored with aplomb against Brentford last week, which he followed with a classy first-time finish against Bayern Munich in the Champions League. He's a man for the big moment in high-profile matches, also evidenced by his goal in his first match at Old Trafford two years ago. 

FanDuel's +180 odds offer the best value, slightly more than BetMGM and DraftKings' +175. With +140 odds, Caesars provides the least value. A winning $10 bet will yield an $18 profit. 


📊 Manchester United vs. Chelsea odds: Matchweek 5

Premier League odds update live in real time.

📈 Manchester United vs. Chelsea betting odds analysis

Manchester United is the slight home underdog, reflecting its poor form to start the season. You'll get the best value on a draw (+260), but these teams have only shared the spoils once in the last five meetings. The total is set at 2.5 goals, with the Over to -172 and the Under +140.


🔢 Manchester United vs. Chelsea results

Manchester United vs. Chelsea history courtesy of 11v11.com.

Date Competition Result Location
May 16, 2025 Premier League Chelsea 1-0 Manchester United Stamford Bridge (London)
Nov. 3, 2024  Premier League Manchester United 1-1 Chelsea Old Trafford (Manchester)
April 4, 2024 Premier League Chelsea 4-3 Manchester United Stamford Bridge (London)
Dec. 6, 2023 Premier League Manchester United 2-1 Chelsea Old Trafford (Manchester)
May 25, 2023 Premier League Manchester United 4-1 Chelsea Old Trafford (Manchester)

📺 Manchester United vs. Chelsea game info

  • When: Saturday, Sept. 20
  • Kickoff: 12:30 p.m. ET
  • Where: Old Trafford (Manchester, England)
  • How to watch: USA Network

❓ Manchester United vs. Chelsea FAQs

Who is favored to win Manchester United vs. Chelsea?

Chelsea is the marginal +150 moneyline betting favorite. 

What is the spread for Manchester United vs. Chelsea?

Chelsea -0.5 is at +135 at DraftKings, with Manchester United +0.5 at -190. 

What is the Over/Under for Manchester United vs. Chelsea?

The total is set at 2.5 goals, with the Over to -172 and the Under +140.

What are the best bets for Manchester United vs. Chelsea?

My best bets are for Chelsea to win (+150) and Cole Palmer to score (+175). 

When is the Manchester United vs. Chelsea game?

The Manchester United vs. Chelsea match is on Saturday, Sept. 20, starting at 12:30 p.m. ET. 

How do soccer odds work?

When betting on soccer, the spread shows how many goals the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by 2 or more goals to cover the spread, while an underdog at +1.5 must win outright or lose by fewer than 1 goal to cover the spread.

Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.

You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.

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