Barcelona vs. Olympiacos Prediction: Champions League Odds, Expert Picks & Best Bets

Last Updated: October 20, 2025 5:13 PM EDT • 3 minute read X Social Google News Link

Champions League action resumes Tuesday, with my Barcelona vs. Olympiacos prediction anticipating a comfortable win for the hosts after the dust settles at the Estadi Olimpic in Spain.
Barcelona are the overwhelming favorites, with most of our best soccer betting sites setting the price at -550 for the Catalan side to beat an Olympiacos team still searching for its first Champions League win heading into the 12:45 p.m ET kickoff on Paramount+. Our Champions League predictions include backing the home side to win by a landslide, as well as a player prop bet focusing on one Barcelona vet who I expect to torment Olympiacos.
⚽ Barcelona vs. Olympiacos predictions
Soccer picks for Tuesday; odds subject to change.
- Game pick: Barcelona -2.5 (+125 via DraftKings) ⭐⭐⭐⭐
- Over/Under pick: Over 3.5 (+100 via Caesars) ⭐⭐⭐⭐
- Player prop pick: Marcus Rashford Over 3.5 shots (-175 via bet365) ⭐⭐⭐
✅ Barcelona vs. Olympiacos expert pick
💸 Barcelona -2.5 (+125) ⭐⭐⭐⭐⭐
It’s going to be a long day at the office for Olympiacos. With Barcelona eager to rebound from their defeat to Paris Saint-Germain in their last Champions League outing, I’m targeting the Catalan side to beat Olympiacos by at least three goals Tuesday.
Barcelona were humbled 4-1 against Sevilla in their next game after playing PSG and fell out of first place in La Liga. The club is also facing multiple injury concerns, with Robert Lewandowski, Ferran Torres, and Raphinha dealing with physical ailments before Barcelona’s clash with Olympiacos.
But there’s still plenty of power in attack to help Barcelona overcome their injury crisis. Lamine Yamal is back and healthy, while a revitalized Marcus Rashford should also play a key role in helping Barcelona continue their dominance at home against Greek opposition. Barcelona have won all seven games they’ve hosted against Greek teams in UEFA competitions.
A successful $10 bet on Barca winning by more than two goals at DraftKings will net a profit of $12.50.
💰 Best Barcelona vs. Olympiacos player prop bet
Our player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
🔥 Marcus Rashford Over 3.5 shots (-175) ⭐⭐⭐
Barcelona’s issues with injuries could result in a big game for Marcus Rashford. Again.
The Manchester United loanee has been thrust into a major role with Barcelona, so expect him to stay busy Tuesday and register more than 3 shots against Olympiacos.
The revitalized English forward has been relied on heavily this season in the Catalan capital after his well-publicized struggles at Manchester United last season. Rashford is one of four players who’ve appeared in all of Barcelona’s games and leads the team in goal contributions with three goals and four assists
With Lamine Yamal likely to command a lot of attention on the other side of the pitch, expect Rashford to use his experience to find open spaces and get opportunities to score. He’s averaging three shots in La Liga and four in the Champions League. A winning $10 bet at bet365 pays a profit of $5.71.
📊 Barcelona vs. Olympiacos odds
Champions League odds updated live in real time.
📺 How to watch Barcelona vs. Olympiacos
- Date: Tuesday, Oct. 21
- Kickoff: 12:45 p.m. ET
- Where: Estadi Olimpic, Barcelona
- TV: Paramount+
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Gordon Brunt