NFL Odds Week 16: Betting Lines, Spreads & Totals for Every Game
NFL odds Week 16, 2025
The NFL odds for Week 16 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Rams vs. Seahawks (TNF) | Seahawks -1.5 | LAR -110 / SEA -110 | 47.5 |
| Eagles vs. Commanders (Saturday) | Commanders +5.5 | PHI -250 / WSH +205 | 45.5 |
| Packers vs. Bears (Saturday) | Bears +3 | GB -165 / CHI +140 | 46.5 |
| Bills vs. Browns | Browns +8.5 | BUF -500 / CLE +375 | 41.5 |
| Bengals vs. Dolphins | Dolphins +1.5 | CIN -125 / MIA +105 | 50.5 |
| Chiefs vs. Titans | Titans +11.5 | KC -800 / TEN +550 | 41.5 |
| Chargers vs. Cowboys | Cowboys -1.5 | LAC +115 / DAL -135 | 48.5 |
| Vikings vs. Giants | Giants +1.5 | MIN -120 / NYG +100 | 43 |
| Jets vs. Saints | Saints -3 | NYJ +160 / NO -190 | 39.5 |
| Buccaneers vs. Panthers | Panthers +1.5 | TB -125 / CAR +105 | 45.5 |
| Falcons vs. Cardinals | Cardinals -1.5 | ATL +100 / ARI -120 | 45.5 |
| Jaguars vs. Broncos | Broncos -2.5 | JAX +125 / DEN -150 | 43.5 |
| Raiders vs. Texans | Texans -12.5 | LV +550 / HOU -800 | 37.5 |
| Steelers vs. Lions | Lions -6.5 | PIT +230 / DET -280 | 49.5 |
| Patriots vs. Ravens (SNF) | Ravens -2.5 | NE +120 / BAL -140 | 48 |
| 49ers vs. Colts (MNF) | Colts +6 | SF -260 / IND +210 | 45.5 |
Our NFL picks will be locked and loaded for Week 16 as the NFL playoff elimination watch continues to take shape.
- The Thursday Night Football odds have the Seahawks lined as a 1.5-point home betting favorite against the Rams in a top-end NFC clash from 8:15 p.m. ET (Prime Video)
- A pair of Saturday games dot the schedule ahead of Christmas:
- The Commanders are a 5.5-point betting underdog against the visiting Eagles an in NFC East battle at Northwest Stadium in Landover, Md., at 5 p.m. ET (FOX)
- The Bears are a 3-point betting underdog against the visiting Packers in an NFC North battle at Soldier Field in Chicago at 8:20 p.m. ET (FOX)
- Sunday's action wraps with the Ravens a 2.5-point home betting favorite over the Patriots per the Sunday Night Football odds, with kickoff from M&T Bank Stadium at 8:20 p.m. ET (NBC)
- The Monday Night Football odds have the Colts as a 6-point home betting underdog against the 49ers at (8:15 p.m. ET, ESPN/ABC)
Rams vs. Seahawks odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from Lumen Field (Seattle)
- How to watch: Prime Video
Eagles vs. Commanders odds: Saturday
- Kickoff: 5 p.m. ET from Northwest Stadium (Landover, Md.)
- How to watch: FOX
Packers vs. Bears odds: Saturday
- Kickoff: 8:20 p.m. ET from Soldier Field (Chicago)
- How to watch: FOX
Patriots vs. Ravens odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from M&T Bank Stadium (Baltimore)
- How to watch: NBC/Peacock
49ers vs. Colts odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Lucas Oil Stadium (Indianapolis)
- How to watch: ESPN/ABC
NFL Week 16 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
Who's playing on prime time in Week 16?
We have our standard three prime time games in Week 16, with the Rams vs. Seahawks on Thursday Night Football, the Patriots vs. Ravens on Sunday Night Football, and 49ers vs. Colts to wrap the week on Monday Night Football. We also get a pair of divisional games on Saturday with
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