Rams vs. Seahawks Prediction & Opening Odds for Thursday Night Football: NFL Week 16

I'm backing the Under in my Rams vs. Seahawks prediction for Thursday Night Football at Lumen Field in Seattle (8:15 p.m. ET, Prime Video). 

The Rams are the 1.5-point betting favorite to win this critical game between the NFC West front-runners. We're expecting a blustery, rainy evening in Seattle, which will contribute to the sound defensive teams combining for 44 points or fewer. The pick below is part of the NFL predictions for Week 16. 

🏈 Early Rams vs. Seahawks prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 16.

Under 44.5 (-104) ⭐⭐⭐

The Seahawks allowed the second-fewest points per game (17.3) before allowing 16 in their Week 15 win over the Indianapolis Colts. They held the Rams to 21 in the narrow two-point defeat at SoFi Stadium in Week 11. 

That defensive performance was even more impressive considering Matthew Stafford and Co. have scored 30 points or more seven times this season. Mike Macdonald's defense hasn't allowed more than 24 points since Week 5 against the Tampa Bay Buccaneers.

The Rams, meanwhile, had the third-best defensive DVOA before Week 15. With rain and windy conditions in the forecast, I expect a comparatively low-scoring contest between teams battling for the NFC West crown. 

FanDuel offers the best price (-104), and a winning $10 bet will profit $9.62. 

📊 Live Rams vs. Seahawks odds: Week 16

See the latest NFL odds for every game in Week 16. 

Rams vs. Seahawks opening odds

• Moneyline: Rams -111 | Seahawks -111
• Spread: Rams +1 (-116) | Seahawks -1 (-105)
• Over/Under: Over 47 (-105) | Under 47 (-116)

Rams vs. Seahawks line movement

The Seahawks are the 1.5-point betting underdog across the best sports betting sites. However, their odds range from -118 to -120, which indicates the number will decrease to +1. While it will likely remain at +1, a pick-em is a distinct possibility in the lead-up to Thursday's kickoff. 

📈 Rams vs. Seahawks trends & betting notes: TNF

• The Seahawks and Rams are 8-7 to the Over
• The Seahawks had the best defensive DVOA before Week 15
• The Rams had the third-best defensive DVOA before Week 15
• Seattle has allowed more than 22 points just once in seven home games
• The Rams allowed fewer than 10 points four times

📺 How to watch Rams vs. Seahawks: Thursday Night Football

• Date: Thursday, Dec. 18
• Kickoff: 8:15 p.m. ET
• Location: Lumen Field (Seattle)
• TV: Prime Video