Rams vs. 49ers Player Props Today: Best Bets & TD Picks for NFL Week 10
Last Updated: November 9, 2025 9:30 AM EST • 3 minute read X Social Google News Link
My best Rams vs. 49ers player props focus on Matthew Stafford, George Kittle, and Davante Adams, ahead of today's game at Levi’s Stadium in Santa Clara, Calif., kicking off at 4:25 p.m. ET (FOX). Though the 49ers won the first game between these two teams, the Rams are the 4.5-point road favorite.
My NFL predictions for Week 10 explain why I expect Stafford and Adams to continue to connect for touchdowns, and why Kittle is in for another rough outing.
✅ Rams vs. 49ers player prop bets
See all of our experts' NFL picks for Week 10
💵 Best Rams vs. 49ers player prop bets
- Matthew Stafford player prop: Over 2.5 passing touchdowns (+145 via BetMGM) ⭐⭐⭐⭐
- George Kittle player prop: Under 52.5 receiving yards (-113 via DraftKings) ⭐⭐⭐⭐
- Davante Adams player prop: Anytime touchdown scorer (-105 via bet365) ⭐⭐⭐⭐⭐
💰 Best Rams vs. 49ers player props
⬆️ Matthew Stafford player prop: Over 2.5 passing touchdowns (+145) ⭐⭐⭐⭐
When these teams met in Week 5, Stafford threw for 389 yards and three touchdowns. He’s thrown at least three touchdowns in four of his last five games, and he has thrown at least four in each of his last two contests.
The 49ers have allowed 15 passing touchdowns this season, tied for the eighth-most in the league. Additionally, the Rams are the eighth-highest scoring team in the league, but only five of their 26 offensive touchdowns have been on the ground.
BetMGM’s price implies a 40.82% chance that Stafford hits this Over. A $10 bet would profit $14.50.
⬇️ George Kittle player prop: Under 52.5 receiving yards (-113) ⭐⭐⭐⭐
Kittle has been wholly ineffective this season. He’s caught just 12 passes for 100 yards in four games, and he’s yet to top 43 yards in a single contest.
The Rams rank sixth-best in the league against tight ends. They’ve allowed just 332 yards (41.5 per game) to the position. Though Kittle has caught four passes in three of his four games, he’s averaging just 8.3 yards per reception, which is right in line with the 8.5 per reception the Rams are allowing to tight ends.
DraftKings’ price of -113 implies Kittle has a 53.05% chance of finishing with a subpar receiving total. A $10 bet would profit $8.85.
🌐 Want more trusted analysis?
Add Sportsbook Review as one of your "source preferences" to see more of our expert picks and predictions in your Google search results and Discover feed.
6️⃣ Best Rams vs. 49ers touchdown scorer bet
🔥 Davante Adams TD pick: Anytime touchdown scorer (-105) ⭐⭐⭐⭐⭐
Adams has scored five touchdowns over his last two games. He’s also scored at least once in five of eight contests. Yet, despite leading the Rams with eight touchdowns, he has a worse price to score than Puka Nacua, and his price of -105 at bet365 is barely better than what many of the best sports betting sites are offering for Kyren Williams (+100), who has scored six times this season.
Adams didn’t score against the 49ers in the first matchup, but he finished with five catches on 11 targets for 88 yards. Clearly, there was something about this matchup the Rams liked, and with Nacua at full strength entering this game, the 49ers won’t be able to focus too much attention on Stafford’s favorite red zone weapon.
The bet365 price of -105 implies a 51.22% chance that Adams scores. A $10 bet would profit $9.52.
💡 More Week 10 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 10.
📊 Rams vs. 49ers anytime touchdown scorer odds
See live NFL odds for every game in Week 10.
🔍️ Find the best odds for every bet
Search the best NFL player prop odds for any team or player across every market from legal sportsbooks in your area.
📺 How to watch Rams vs. 49ers
- Date: Sunday, Nov. 9
- Kickoff: 4:25 p.m. ET
- Location: Levi's Stadium (Santa Clara, Calif.)
- TV: FOX
💡 NFL expert picks for Week 10
Follow all of our NFL analysis for Week 10 throughout the week.
- NFL picks against the spread Week 10
- NFL QB clutch player ratings Week 10
- NFL survivor picks Week 10
- NFL AI predictions Week 10
- NFL weather report Week 10
- NFL upset picks Week 10
- NFL player props Week 10
- NFL expert picks Week 10
- NFL best bets Week 10
- NFL moneyline picks Week 10
- NFL anytime touchdown scorer predictions Week 10
- NFL first touchdown scorer predictions Week 10
- NFL 2+ touchdown scorer predictions Week 10
- NFL anytime touchdown scorer parlay Week 10
- NFL long-shot parlay Week 10
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Philip Wood X social