NFL Predictions: Best Prime-Time Bets for Week 2
It's time to dive into my best prime-time bets for Week 2, and it doesn't get much better than this. Who will dominate under the brightest lights in America? Let's get right into my NFL picks for the marquee games on the schedule this week.
π NFL prime-time schedule for Week 2
| Matchup | Date | Time | Location (Home Team) | Odds (Favorite) |
|---|---|---|---|---|
| Commanders @ Packers | Thu, Sep 11 | 8:15 PM ET | Lambeau Field, Green Bay | Packers β3.5 FOX Sports |
| Chiefs @ Eagles | Sun, Sep 14 | 4:25 PM ET | Arrowhead Stadium, Kansas City | Eagles β1.5 FOX Sports |
| Falcons @ Vikings | Sun, Sep 14 | 8:20 PM ET | U.S. Bank Stadium, Minneapolis | Vikings β3.5 FOX Sports |
| Buccaneers @ Texans | Mon, Sep 15 | 7:00 PM ET | NRG Stadium, Houston | Texans β2.5 FOX Sports |
| Chargers @ Raiders | Mon, Sep 15 | 10:00 PM ET | Allegiant Stadium, Las Vegas | Chargers β3.5 FOX Sports |
β΅οΈ Buccaneers (+2.5) vs. π Texans
The Texans just don't seem like the same team lately we've been accustomed to seeing. CJ Stroud, the third-year gunslinger, threw for under 200 yards in two of his final regular-season starts in 2024, and he began this season with a 19-for-27, 188-yard performance against the Los Angeles Rams in Week 1. This offense might look different to begin 2025 without Tank Dell and Joe Mixon.
Conversely, the Bucs looked much more polished in Week 1, with Baker Mayfield making the most of his 167 yards through the air while throwing three touchdown passes, including a game-winning toss to rookie standout Emeka Egbuka. The defensive unit did bend, but it didn't break for the most part to open the season, which should help us cash this plus-money play on Monday Night Football.
- Best bet: Buccaneers moneyline (+126 via FanDuel)
- Best total prediction: Over 42.5 (-118)
- Best player prop: Baker Mayfield Over passing yards
π Buccaneers vs Texans odds for Monday Night Football
β‘οΈChargers (-3) vs. π΄ββ οΈ Raiders
The Chargers dispatched the Chiefs on Friday Night Football in Brazil, and they're laying just 3 points against the Raiders, who squeaked past a Patriots team that has no intention of making the playoffs.
While Las Vegas does boast Offensive Rookie of the Year odds favorite Ashton Jeanty, he averaged just two yards per carry in Week 1. He'll endure another tough time against the Chargers' strong run defense.
Los Angeles' offense will be difficult to stop if last week is any indication, too, with Justin Herbert throwing for over 300 yards and three touchdowns. Give me the Chargers all day here, and it could very well be my lock of the week.
- Best bet: Chargers -3 (-120)
- Best total prediction: Over 46.5 (-115)
- Best player prop: Ashton Jeanty Under rushing yards
π Chargers vs. Raiders odds on Monday Night Football
π NFL prime-time predictions for Week 2: Monday Night Football
Track the latest NFL scores for line movement and matchup info.
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