NFL Predictions Week 5: Best Bets & Odds for Every Game
If you liked the first four weeks of NFL football, our NFL predictions for Week 5 should have you throughly entertained through the first week of October. We're offering our NFL picks with the latest live odds for every Week 5 matchup from Thursday Night Football through Monday Night Football.
🏈 NFL predictions for Week 5
- 49ers vs. Rams prediction (coming soon)
- Early 49ers vs. Rams prediction (coming soon)
- 49ers vs. Rams player props (coming soon)
- 49ers vs. Rams parlay picks (coming soon)
- 49ers vs. Rams anytime touchdown scorer predictions (coming soon)
- 49ers vs. Rams first touchdown scorer predictions (coming soon)
- 49ers vs. Rams expert picks (coming soon)
- Vikings vs. Browns prediction (coming soon)
- Early Vikings vs. Browns prediction (coming soon)
- Vikings vs. Browns player props (coming soon)
- Vikings vs. Browns parlay picks (coming soon)
- Vikings vs. Browns anytime touchdown scorer predictions (coming soon)
- Cowboys vs. Jets player props (coming soon)
- Broncos vs. Eagles player props (coming soon)
- Texans vs. Ravens player props (coming soon)
- Buccaneers vs. Seahawks player props (coming soon)
- Lions vs. Bengals player props (coming soon)
- Commanders vs. Chargers player props (coming soon)
- Patriots vs. Bills prediction (coming soon)
- Early Patriots vs. Bills prediction (coming soon)
- Patriots vs. Bills player props (coming soon)
- Patriots vs. Bills anytime touchdown scorer predictions (coming soon)
- Patriots vs. Bills first touchdown scorer predictions (coming soon)
- Patriots vs. Bills expert picks (coming soon)
- Chiefs vs. Jaguars prediction (coming soon)
- Early Chiefs vs. Jaguars prediction (coming soon)
- Chiefs vs. Jaguars player props (coming soon)
- Chiefs vs. Jaguars anytime touchdown scorer predictions (coming soon)
- Chiefs vs. Jaguars first touchdown scorer predictions (coming soon)
- Chiefs vs. Jaguars expert picks (coming soon)
💰 NFL odds & expert picks: Week 5
Live NFL odds for every Week 5 game; updated in real time.
📊 49ers vs. Rams odds
- Date: Thursday, Oct. 2
- Kickoff: 8:15 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- How to watch: Prime Video
🔮 Early 49ers vs. Rams prediction
🐏 Rams -3 (-120)
Both of these teams are fortunate to be 3-1, but the Rams are the better side on a per-play basis and enter this matchup a little healthier, too. It doesn't hurt that L.A. has won the last three meetings.
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📊 Vikings vs. Browns odds
- Date: Sunday, Oct. 5
- Kickoff: 9:30 a.m. ET
- Location: Tottenham Hotspur Stadium (London)
- How to watch: NFL Network
🔮 Early Vikings vs. Browns prediction
🟣 Vikings -3.5 (-110)
I'm not sure what to make of the Vikings after two pitiful performances sandwiching a stellar one, though I have even less faith in a Browns offense averaging 14 PPG. Minnesota should benefit from less fatigue after traveling from Dublin to this game in London.
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📊 Cowboys vs. Jets odds
- Date: Sunday, Oct. 5
- Kickoff: 1 p.m. ET
- Location: MetLife Stadium (East Rutherford, N.J.)
- How to watch: FOX
🔮 Early Cowboys vs. Jets prediction
🤠 Cowboys -1.5 (-110)
I don't want to buy high after a tie (if that's even possible), but the Cowboys' offense looked sharp even without CeeDee Lamb in the mix. I think New York is a touch underrated, though Dallas should win this outright.
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📊 Broncos vs. Eagles odds
- Date: Sunday, Oct. 5
- Kickoff: 1 p.m. ET
- Location: Lincoln Financial Field (Philadelphia)
- How to watch: CBS
🔮 Early Broncos vs. Eagles prediction
🐎 Broncos +5.5 (-110)
Maybe I'm too high on the Broncos, but I don't expect this game to get away from Denver - it rarely does when Philly is involved. This should remain close until the end in what I'd expect to be a defensive struggle.
📊 Texans vs. Ravens odds
- Date: Sunday, Oct. 5
- Kickoff: 1 p.m. ET
- Location: M&T Bank Stadium (Baltimore)
- How to watch: CBS
🔮 Early Texans vs. Ravens prediction
🐦⬛ Ravens -7.5 (-105)
The injuries are piling up for the Ravens, but I'd expect Lamar Jackson to suit up against a similarly banged-up Texans team that hasn't quite looked right this year. Baltimore has won six straight in this series by an average of 21.2 points - the last five games were decided by 16 or more.
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📊 Giants vs. Saints odds
- Date: Sunday, Oct. 5
- Kickoff: 1 p.m. ET
- Location: Caesars Superdome (New Orleans)
- How to watch: FOX
🔮 Early Giants vs. Saints prediction
🗽 Giants -1.5 (-110)
Jaxson Dart brought a new spark to the Giants in his first career start to snap a winless start, and the defense has been overlooked all year. The Saints have a penchant for close losses, so I don't mind laying such a small line on the road favorite.
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📊 Raiders vs. Colts odds
- Date: Sunday, Oct. 5
- Kickoff: 1 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- How to watch: CBS
🔮 Early Raiders vs. Colts prediction
🐴 Colts -6.5 (-110)
Indianapolis is unbeaten no more after a last-second loss to the Rams, but I've still been impressed with Shane Steichen's group through four weeks. I can't say the same about Pete Carroll's Raiders, who are making the easy things difficult amid a 1-3 start.
📊 Dolphins vs. Panthers odds
- Date: Sunday, Oct. 5
- Kickoff: 1 p.m. ET
- Location: Bank of America Stadium (Charlotte, N.C.)
- How to watch: CBS
🔮 Early Dolphins vs. Panthers prediction
🐬 Dolphins -1 (-110)
Are these the two worst teams in the NFL? I can't believe I'm laying the points on the 'Fins, but that's how bad the Panthers look right now after a 29-point loss.
📊 Buccaneers vs. Seahawks odds
- Date: Sunday, Oct. 5
- Kickoff: 4:05 p.m. ET
- Location: Lumen Field (Seattle)
- How to watch: FOX
🔮 Early Buccaneers vs. Seahawks prediction
🟢 Seahawks -2.5 (-120)
These are two of my favorite teams in the league through four weeks, though I trust the Seahawks' defense more than any other unit on the field in this NFC matchup. Don't be surprised if that side makes a play late to win this one.
📊 Titans vs. Cardinals odds
- Date: Sunday, Oct. 5
- Kickoff: 4:05 p.m. ET
- Location: State Farm Stadium (Glendale, Ariz.)
- How to watch: FOX
🔮 Early Titans vs. Cardinals prediction
⚔️ Titans +9.5 (-105)
You could not pay me money to lay 9.5 points on the Cardinals, whose four games have all been decided in the final minute. I expect a better effort from Tennessee this week than last week's dud in Houston.
📊 Commanders vs. Chargers odds
- Date: Sunday, Oct. 5
- Kickoff: 4:25 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- How to watch: CBS
🔮 Early Commanders vs. Chargers prediction
⚡️ Chargers -2.5 (-115)
The Chargers clearly overlooked the Giants in a surprising Week 3 loss, but they're still the better team in this matchup - even if Jayden Daniels is back for the Commanders. Expect L.A. defensive coordinator Jesse Minter to make life difficult for him if he returns.
📊 Lions vs. Bengals odds
- Date: Sunday, Oct. 5
- Kickoff: 4:25 p.m. ET
- Location: Paycor Stadium (Cincinnati)
- How to watch: FOX
🔮 Early Lions vs. Bengals prediction
🦁 Lions -8.5 (-110)
Until the Lions take their foot off the gas, I'm inclined to lay the points on Dan Campbell's group until further notice. This is a clear mismatch against a Bengals team teetering on disaster.
📊 Patriots vs. Bills odds
- Date: Sunday, Oct. 5
- Kickoff: 8:20 p.m. ET
- Location: Highmark Stadium (Orchard Park, N.Y.)
- How to watch: NBC
🔮 Early Patriots vs. Bills prediction
🪖 Patriots +8.5 (-105)
The Bills have a tendency to play with their food, even if they've survived every week en route to a 4-0 start. The Patriots have shown enough to deserve more respect from oddsmakers against a familiar foe.
📊 Chiefs vs. Jaguars odds
- Date: Monday, Oct. 6
- Kickoff: 8:15 p.m. ET
- Location: EverBank Stadium (Jacksonville, Fla.)
- How to watch: ESPN
🔮 Early Chiefs vs. Jaguars prediction
🐆 Jaguars +3 (-105)
No team had a bigger win last week than Kansas City, which sets up the perfect opportunity to sell high against a sneaky Jaguars side that came a few seconds away from a 4-0 start.
💡 NFL expert picks for Week 5
- NFL picks against the spread Week 5 (coming soon)
- NFL fantasy pickup player props Week 5 (coming soon)
- NFL weather report Week 5 (coming soon)
- NFL QB clutch player ratings Week 5 (coming soon)
- NFL rookie player props Week 5 (coming soon)
- NFL survivor picks Week 5 (coming soon)
- NFL upset picks Week 5 (coming soon)
- NFL moneyline picks Week 5 (coming soon)
- How to bet Week 5 on a $20 budget (coming soon)
- NFL AI predictions Week 5 (coming soon)
- NFL player props Week 5 (coming soon)
- NFL expert picks Week 5 (coming soon)
- NFL live betting guide Week 5 (coming soon)
- NFL anytime touchdown scorer predictions Week 5 (coming soon)
- NFL anytime touchdown scorer parlay Week 5 (coming soon)
- NFL best bets Week 5 (coming soon)
- NFL long-shot parlay Week 5 (coming soon)
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