NFL Predictions Week 3: Best Bets & Odds for Every Game This Week

With all 32 teams in action again this week, we're breaking down our NFL predictions and best bets for every game.

Last Updated: September 15, 2025 8:00 AM EDT • 7 minute read

Pictured: Tyler Bass boots a 61-yard field goal with five seconds left to help the Bills defeat the Dolphins. Photo by Tina MacIntyre-Yee / USA TODAY NETWORK via Imagn Images.

Our NFL predictions for Week 3 gather all of our best NFL picks from our betting experts into one spot as we offer our best bets for every game, starting with the Thursday Night Football clash between the Miami Dolphins and Buffalo Bills all the way through Monday Night Football.

🏈 NFL predictions for Week 3

Track the latest NFL scores for line movement and matchup info.

Dolphins vs. Bills prediction

Early Dolphins vs. Bills prediction
Dolphins vs. Bills player props
Dolphins vs. Bills parlay picks
Dolphins vs. Bills anytime touchdown scorer predictions
Dolphins vs. Bills first touchdown scorer predictions
Dolphins vs. Bills expert picks

Packers vs. Browns player props
Bengals vs. Vikings player props
Rams vs. Eagles player props
Steelers vs. Patriots player props
Jets vs. Buccaneers player props
Broncos vs. Chargers player props
Cowboys vs. Bears player props
Chiefs vs. Giants prediction

Early Chiefs vs. Giants prediction
Chiefs vs. Giants player props
Chiefs vs. Giants parlay picks
Chiefs vs. Giants anytime touchdown scorer predictions
Chiefs vs. Giants first touchdown scorer predictions
Chiefs vs. Giants expert picks

Lions vs. Ravens prediction

Early Lions vs. Ravens prediction
Lions vs. Ravens player props
Lions vs. Ravens parlay picks
Lions vs. Ravens anytime touchdown scorer predictions
Lions vs. Ravens first touchdown scorer predictions
Lions vs. Ravens expert picks

💰 NFL odds & expert picks: Week 3

Live odds from our best NFL betting sites; updated in real time.

📊 Dolphins vs. Bills odds

Date: Thursday, Sept. 18
Kickoff: 8:15 p.m. ET
Location: Highmark Stadium (Orchard Park, N.Y.)
How to watch: Prime Video
Early pick: Bills -12.5 (-110 via BetMGM)

The Bills open as a 12.5-point betting favorite over the Miami Dolphins for this AFC East divisional rivalry. It's hard for me to look away from the favorites here given the total disarray on both sides of the ball for Miami right now.

📊 Colts vs. Titans odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Nissan Stadium (Nashville, Tenn.)
How to watch: CBS
Early pick: Titans +3.5 (-115 via ESPN BET)

The Colts open as a 3.5-point betting favorite over the Titans following a 2-0 start for Indianapolis following its wacky Week 2 win. I like what I've seen from Tennessee, which has played better than its 0-2 start suggests, and this feels like the quintessential spot to fade Daniel Jones in his first road start for Indy.

📊 Steelers vs. Patriots odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Gillette Stadium (Foxborough, Mass.)
How to watch: CBS
Early pick: Patriots +1.5 (-115 via DraftKings)

The Steelers open as a 1.5-point betting favorite over the Patriots after a 1-1 start for each side through two weeks. Pittsburgh's Week 1 win is driving the hype in this market for the road favorites, but I have more faith in Mike Vrabel at home than I do in Aaron Rodgers and Co. after last week's loss.

📊 Jets vs. Buccaneers odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Raymond James Stadium (Tampa, Fla.)
How to watch: FOX
Early pick: Buccaneers -6.5 (-110 via FanDuel)

The Buccaneers open as a 6.5-point betting favorite over the Jets following New York's costly loss last week that saw Justin Fields (concussion) leave in the fourth quarter. If he isn't healthy, I don't see the Jets' path to keeping this within a score, especially given their clear issues defensively.

📊 Raiders vs. Commanders odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Northwest Stadium (Landover, Md.)
How to watch: FOX
Early pick: Commanders -5.5 (-118 via FanDuel)

The Commanders open as a 5.5-point betting favorite over the Raiders following a Thursday loss for Washington last week. I fully expect Jayden Daniels and Co. to bounce back in a favorable home spot against the Raiders, who enter this one at a major rest disadvantage after playing Monday.

📊 Rams vs. Eagles odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Lincoln Financial Field (Philadelphia)
How to watch: FOX
Early pick: Rams +4.5 (-110 via DraftKings)

The Eagles open as a 4.5-point betting favorite over the Rams after a 2-0 start for each side ahead of this playoff rematch. I'm as impressed as anyone else by Philly's gutsy start, but the Eagles' style lends itself to close games against top opponents, which is what I'd expect to see again in Week 3.

📊 Falcons vs. Panthers odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Bank of America Stadium (Charlotte, N.C.)
How to watch: FOX
Early pick: Falcons -3.5 (-105 via Caesars)

The Falcons open as a 3.5-point betting favorite over the Panthers in this NFC South clash between teams trending in the opposite direction. Carolina is an absolute mess right now on both sides of the ball, while Atlanta is looking like a complete team after a defensive masterclass from its rookie pass rushers.

📊 Bengals vs. Vikings odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: U.S. Bank Stadium (Minneapolis)
How to watch: FOX
Early pick: Vikings -3.5 (-110 via FanDuel)

The Vikings open as a 3.5-point betting favorite over the Bengals, who will turn to Jake Browning for his first start of the 2025 season. I'm frankly shocked this line is only a 3.5-point advantage for Minnesota, which should be able to bounce back this week against a flawed opponent in a tough road spot.

📊 Texans vs. Jaguars odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: EverBank Stadium (Jacksonville, Fla.)
How to watch: CBS
Early pick: Jaguars -1.5 (-102 via DraftKings)

The Jaguars open as a 1.5-point betting favorite over the Texans in this clash between AFC South contenders looking to keep pace with the Colts. I have a lot more faith in Trevor Lawrence and Co. to win this one at home with the way that Houston's offensive line has hampered its offensive upside.

📊 Packers vs. Browns odds

Date: Sunday, Sept. 21
Kickoff: 1 p.m. ET
Location: Huntington Bank Field (Cleveland)
How to watch: FOX
Early pick: Packers -8.5 (-110 via bet365)

The Packers open as an 8.5-point betting favorite over the Browns in a matchup between two teams with entirely different profiles. Green Bay looks like a legitimate Super Bowl contender right now, while Cleveland doesn't have the quarterback play to match a valiant effort from its defense each week.

📊 Broncos vs. Chargers odds

Date: Sunday, Sept. 21
Kickoff: 4:05 p.m. ET
Location: SoFi Stadium (Inglewood, Calif.)
How to watch: CBS
Early pick: Chargers -2.5 (-110 via Caesars)

The Chargers open as a 2.5-point betting favorite over the Broncos for this AFC West clash in Los Angeles. I was high on Denver entering the season, but I'm not sure we've seen enough to justify betting against the Bolts, who have looked like the sharper team thus far on both sides of the ball.

📊 Saints vs. Seahawks odds

Date: Sunday, Sept. 21
Kickoff: 4:05 p.m. ET
Location: Lumen Field (Seattle)
How to watch: FOX
Early pick: Seahawks -7 (-122 via FanDuel)

The Seahawks open as a 7-point betting favorite over the Saints after their 14-point road win against the Steelers last week. This is a clear mismatch on paper for a Saints team that continues to hang tough, which will be harder to pull off in a raucous road environment in Seattle.

📊 Cardinals vs. 49ers odds

Date: Sunday, Sept. 21
Kickoff: 4:25 p.m. ET
Location: Levi's Stadium (Santa Clara, Calif.)
How to watch: FOX
Early pick: Cardinals -1 (-105 via bet365)

The Cardinals open as a 1-point betting favorite over the 49ers with injuries plaguing the home underdogs in this NFC West duel. With Brock Purdy unlikely to play in Week 3, I have a hard time placing my faith in this depleted San Francisco roster against the quietly undefeated Cardinals.

📊 Cowboys vs. Bears odds

Date: Sunday, Sept. 21
Kickoff: 4:25 p.m. ET
Location: Soldier Field (Chicago)
How to watch: FOX
Early pick: Cowboys +1.5 (-115 via DraftKings)

The Bears open as a 1.5-point betting favorite over the Cowboys even after an 0-2 start to the season in Ben Johnson's first year as head coach. I would love to bet on a bounce-back effort for Chicago in Week 3, but I simply don't have enough faith in Caleb Williams' current form to lay any points on the Bears right now.

📊 Chiefs vs. Giants odds

Date: Sunday, Sept. 21
Kickoff: 8:20 p.m. ET
Location: MetLife Stadium (East Rutherford, N.J.)
How to watch: NBC
Early pick: Giants +6 (-115 via BetMGM)

The Chiefs open as a 6-point betting favorite over the Giants despite an 0-2 start for the defending AFC champions. Don't sleep on the G-Men after a wild two weeks that have seen Russell Wilson top the passing charts, which could put pressure on a Kansas City offense that looks lethargic thus far.

📊 Lions vs. Ravens odds

Date: Monday, Sept. 22
Kickoff: 8:15 p.m. ET
Location: M&T Bank Stadium (Baltimore)
How to watch: ESPN
Early pick: Ravens -5.5 (-118 via FanDuel)

The Ravens open as a 5.5-point betting favorite over the Lions in a matchup between 1-1 teams coming off blowout wins last week. I trust what I've seen from Baltimore through the first two weeks more than I do for Detroit, which beat up on the Bears but could struggle to trade punches with Lamar Jackson and Co. in a tough road environment.

💡 NFL expert picks for Week 3

NFL picks against the spread Week 3 (coming soon)
NFL fantasy pickup player props Week 3 (coming soon)
NFL weather report Week 3 (coming soon)
NFL upset picks Week 3 (coming soon)
NFL survivor picks Week 3 (coming soon)
NFL QB clutch player ratings Week 3 (coming soon)
How to bet Week 3 on a $100 budget (coming soon)
NFL rookie player props Week 3 (coming soon)
NFL moneyline picks Week 3 (coming soon)
NFL moneyline parlay Week 3 (coming soon)
NFL AI predictions Week 3 (coming soon)
NFL player props Week 3 (coming soon)
NFL expert picks Week 3 (coming soon)
NFL live betting guide Week 3 (coming soon)
NFL anytime touchdown scorer predictions Week 3 (coming soon)
NFL anytime touchdown scorer parlay Week 3 (coming soon)
NFL best bets Week 3 (coming soon)
NFL long-shot parlay Week 3 (coming soon)

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Written by:
C Jackson Cowart

C Jackson Cowart is the Senior Publishing Editor at Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media and NFL experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.