NFL Predictions Week 12: Best Bets & Live Odds for Monday Night Football

We're breaking down our NFL predictions with the latest odds for every Week 12 game.
San Francisco 49ers quarterback Brock Purdy (13) scrambles out of the pocket as we offer our NFL predictions for Monday Night Football.
Pictured: San Francisco 49ers quarterback Brock Purdy (13) scrambles out of the pocket as we offer our NFL predictions for Monday Night Football. Photo by Joe Rondone / The Republic via Imagn Images.
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Our NFL predictions for Week 12 feature our best bet and live odds for every matchup this week. Bookmark this page and check back often as we'll be updating it throughout the week with our best ATS picks, player prop bets, O/U predictions, and more for every single game this week.


🏈 NFL predictions for Week 12

See all of our experts' NFL picks for every Week 12 game.


💰 NFL odds & expert picks: Week 12

Live NFL odds for every Week 12 game; updated in real time.

📊 Panthers vs. 49ers odds

  • Date: Monday, Nov. 24
  • Kickoff: 8:15 p.m. ET
  • Location: Levi’s Stadium (Santa Clara, Calif.)
  • TV: ESPN

🔮 Panthers vs. 49ers prediction

⛏️ 49ers -7 (-120)

The 49ers have the sixth-best offense in terms of DVOA, and they're the healthiest they've been all season. In his return, Brock Purdy led his team to 42 points last week against the Arizona Cardinals. Only once before had the 49ers scored more than 30.

-via Gary Pearson's Panthers vs. 49ers prediction


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