NFL Predictions Week 12: Best Bets & Live Odds for Monday Night Football
Last Updated: November 24, 2025 6:58 PM EST • 1 minute read X Social Google News Link
Our NFL predictions for Week 12 feature our best bet and live odds for every matchup this week. Bookmark this page and check back often as we'll be updating it throughout the week with our best ATS picks, player prop bets, O/U predictions, and more for every single game this week.
🏈 NFL predictions for Week 12
See all of our experts' NFL picks for every Week 12 game.
- Panthers vs. 49ers prediction
- Panthers vs. 49ers player props
- Panthers vs. 49ers same-game parlay
- Panthers vs. 49ers anytime touchdown scorer predictions
- Panthers vs. 49ers first touchdown scorer predictions
- Brock Purdy player props
- Bryce Young player props
- Panthers vs. 49ers weather report
- Panthers vs. 49ers AI predictions
- Panthers vs. 49ers best bets
💰 NFL odds & expert picks: Week 12
Live NFL odds for every Week 12 game; updated in real time.
📊 Panthers vs. 49ers odds
- Date: Monday, Nov. 24
- Kickoff: 8:15 p.m. ET
- Location: Levi’s Stadium (Santa Clara, Calif.)
- TV: ESPN
🔮 Panthers vs. 49ers prediction
⛏️ 49ers -7 (-120)
The 49ers have the sixth-best offense in terms of DVOA, and they're the healthiest they've been all season. In his return, Brock Purdy led his team to 42 points last week against the Arizona Cardinals. Only once before had the 49ers scored more than 30.
-via Gary Pearson's Panthers vs. 49ers prediction
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