NFL Predictions Week 12: Best Bets & Live Odds for Every Game This Week

Our NFL predictions for Week 12 feature our best bet and live odds for all 14 matchups this week, starting with Bills vs. Texans on Thursday Night Football all the way through Panthers vs. 49ers on Monday Night Football. Bookmark this page as we'll be updating it throughout the week with our best ATS picks, player prop bets, O/U predictions, and more for every single game this week.

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🏈 NFL predictions for Week 12

See all of our experts' NFL picks for every Week 12 game.

• Early Bills vs. Texans prediction
• Bills vs. Texans prediction (coming soon)
• Bills vs. Texans player props (coming soon)
• Bills vs. Texans same-game parlay (coming soon)
• Josh Allen player prop bets (coming soon)
• Bills vs. Texans anytime touchdown scorer predictions (coming soon)
• Bills vs. Texans first touchdown scorer predictions (coming soon)
• Bills vs. Texans AI predictions (coming soon)
• Bills vs. Texans expert picks (coming soon)
• Steelers vs. Bears player props (coming soon)
• Patriots vs. Bengals player props (coming soon)
• Giants vs. Lions player props (coming soon)
• Vikings vs. Packers player props (coming soon)
• Seahawks vs. Titans player props (coming soon)
• Colts vs. Chiefs player props (coming soon)
• Jets vs. Ravens player props (coming soon)
• Browns vs. Raiders player props (coming soon)
• Jaguars vs. Cardinals player props (coming soon)
• Falcons vs. Saints player props (coming soon)
• Eagles vs. Cowboys player props (coming soon)
• Eagles vs. Cowboys anytime touchdown scorer predictions (coming soon)
• Eagles vs. Cowboys same-game parlay (coming soon)
• Early Buccaneers vs. Rams prediction
• Buccaneers vs. Rams prediction (coming soon)
• Buccaneers vs. Rams player props (coming soon)
• Buccaneers vs. Rams same-game parlay (coming soon)
• Puka Nacua player props (coming soon)
• Buccaneers vs. Rams anytime touchdown scorer predictions (coming soon)
• Buccaneers vs. Rams first touchdown scorer predictions (coming soon)
• Buccaneers vs. Rams AI predictions (coming soon)
• Buccaneers vs. Rams expert picks (coming soon)
• Early Panthers vs. 49ers prediction (coming soon)
• Panthers vs. 49ers prediction (coming soon)
• Panthers vs. 49ers player props (coming soon)
• Panthers vs. 49ers same-game parlay (coming soon)
• Panthers vs. 49ers anytime touchdown scorer predictions (coming soon)
• Panthers vs. 49ers first touchdown scorer predictions (coming soon)
• Panthers vs. 49ers weather report (coming soon)
• Panthers vs. 49ers AI predictions (coming soon)
• Panthers vs. 49ers expert picks (coming soon)

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💰 NFL odds & expert picks: Week 12

Live NFL odds for every Week 12 game; updated in real time.

📊 Bills vs. Texans odds

• Date: Thursday, Nov. 20
• Kickoff: 8:15 p.m. ET
• Location: NRG Stadium (Houston)
• TV: Prime Video

🔮 Early Bills vs. Texans prediction

🐃 Texans +3.5 (-110)

The Texans had the best defensive DVOA entering Week 11 and have conceded the fewest points per game, allowing 20 points or more three times. The Texans are 3-2 straight up and ATS at NRG Stadium, with their two defeats coming by a combined four points. They have a rare ability to make Josh Allen appear human, which they did in last season's 23-20 home win over the Bills.

-via Gary Pearson's Early Bills vs. Texans prediction

📊 Vikings vs. Packers odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: Lambeau Field (Green Bay, Wis.)
• TV: FOX

🔮 Early Vikings vs. Packers prediction

🟣 Vikings +6.5 (-114)

It brings me no pleasure to bet on J.J. McCarthy after his brutal showing last week, but the Vikings still nearly won thanks to their playmaking defense. The Packers have a nasty habit of hanging around with lesser competition, which I expect to continue against a familiar foe.

📊 Colts vs. Chiefs odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
• TV: CBS

🔮 Early Colts vs. Chiefs prediction

🐴 Colts +3.5 (-105)

The Colts' white-hot start was watered down in the two weeks before a bye, but Indianapolis should give Kansas City issues after a week off. This is a tough matchup for the Chiefs that has upset alert written all over it.

📊 Patriots vs. Bengals odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: Paycor Stadium (Cincinnati)
• TV: CBS

🔮 Early Patriots vs. Bengals prediction

🪖 Patriots -7 (-105)

I'd be inclined to wait until later in the week to see if anyone gets tempted by the Bengals as big 'dogs. It wouldn't be me, though, as I'm too smitten with Drake Maye and Co. against a Cincinnati team that knows its season is effectively over.

📊 Steelers vs. Bears odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: Soldier Field (Chicago)
• TV: FOX

🔮 Early Steelers vs. Bears prediction

🐻 Bears -3 (-105)

I'm awfully surprised to see this line sitting at 3 even with Aaron Rodgers seeming unlikely to play next Sunday at Soldier Field. The Bears aren't perfect, but they're still 7-3 with similar roster talent to the Steelers - this feels like a bargain at home.

📊 Jets vs. Ravens odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: M&T Bank Stadium (Baltimore)
• TV: CBS

🔮 Early Jets vs. Ravens prediction

✈️ Jets +14.5 (-115)

I've been buying Ravens stock ever since their 1-5 start, but even this is too rich for me against a frisky Jets team whose eight losses have come by just over eight points per game. I don't think New York wins, but it could offer intrigue into the fourth.

📊 Giants vs. Lions odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: Ford Field (Detroit)
• TV: FOX

🔮 Early Giants vs. Lions prediction

🦁 Lions -10.5 (-115)

The Eagles completely embarrassed what has otherwise been a prolific Lions offense this season. The Giants have a solid pass rush but not much else; expect a motivated Detroit side to take advantage.

📊 Seahawks vs. Titans odds

• Date: Sunday, Nov. 23
• Kickoff: 1 p.m. ET
• Location: Nissan Stadium (Nashville, Tenn.)
• TV: CBS

🔮 Early Seahawks vs. Titans prediction

⚔️ Titans +13 (-110)

Seattle's offense is better than it showed last week against a division rival, but this still feels like a big ask against the Titans, who have hung around against much better teams already.

📊 Jaguars vs. Cardinals odds

• Date: Sunday, Nov. 23
• Kickoff: 4:05 p.m. ET
• Location: State Farm Stadium (Glendale, Ariz.)
• TV: FOX

🔮 Early Jaguars vs. Cardinals prediction

🐆 Jaguars -2.5 (-110)

I don't want to overreact to the Jaguars' dismantling of the Chargers last week, though I was already high on Jacksonville before its recent swoon. I expect more of what we saw most recently against the overmatched Cardinals.

📊 Browns vs. Raiders odds

• Date: Sunday, Nov. 23
• Kickoff: 4:05 p.m. ET
• Location: Allegiant Stadium (Las Vegas)
• TV: CBS

🔮 Early Browns vs. Raiders prediction

🏴‍☠️ Raiders -3 (-105)

If Shedeur Sanders steps anywhere near the field next Sunday, this might be one of my biggest bets of the season. The Raiders are no contender, but they're competent on both sides of the ball, which is too generous to say about the Browns offense right now.

📊 Eagles vs. Cowboys odds

• Date: Sunday, Nov. 23
• Kickoff: 4:25 p.m. ET
• Location: AT&T Stadium (Arlington, Texas)
• TV: FOX

🔮 Early Eagles vs. Cowboys prediction

🦅 Eagles -4.5 (-108)

How could you not walk away impressed with what we saw from Philly's defense on Sunday night? The offense has the talent but lacks the rhythm; it shouldn't matter against the Cowboys' porous defense and inconsistent offense.

📊 Falcons vs. Saints odds

• Date: Sunday, Nov. 23
• Kickoff: 4:25 p.m. ET
• Location: Caesars Superdome (New Orleans)
• TV: CBS

🔮 Early Falcons vs. Saints prediction

🪶 Falcons -1.5 (-112)

This market could be in flux this week depending on the status of Falcons QB Michael Penix Jr. I'm not sure how much it'll matter with Kirk Cousins stepping in and Bijan Robinson carrying most of the load, anyway. If Atlanta's pass rush can rattle Tyler Shough, that should be enough to win it.

📊 Buccaneers vs. Rams odds

• Date: Sunday, Nov. 23
• Kickoff: 8:20 p.m. ET
• Location: SoFi Stadium (Inglewood, Calif.)
• TV: NBC

🔮 Early Buccaneers vs. Rams prediction

⬇️ Under 49.5 (-110)

Four of the Rams’ last five opponents have scored 19 or fewer. Meanwhile, the Buccaneers’ once high-powered offense has scored just nine touchdowns in their last four games. The unit managed just one touchdown against the Detroit Lions and one against the New Orleans Saints, two teams that rank significantly worse than the Rams in scoring.

-via Philip Wood's Early Buccaneers vs. Rams prediction

📊 Panthers vs. 49ers odds

• Date: Monday, Nov. 24
• Kickoff: 8:15 p.m. ET
• Location: Levi’s Stadium (Santa Clara, Calif.)
• TV: ESPN

🔮 Early Panthers vs. 49ers prediction

🐾 Panthers +7 (-105)

The Panthers strike when you least expect it, and this seems like a spot for Bryce Young and Co. to carry momentum from last week's OT thriller and challenge one of the legacy contenders in the NFC. I like Carolina to keep it close at the very least.

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💡 NFL expert picks for Week 12

Follow all of our NFL analysis for Week 12 throughout the week.

• NFL picks against the spread Week 12 (coming soon)
• NFL survivor picks Week 12 (coming soon)
• QB clutch player ratings Week 12 (coming soon)
• NFL AI predictions Week 12 (coming soon)
• NFL weather report Week 12 (coming soon)
• NFL player props Week 12 (coming soon)
• NFL best bets Week 12 (coming soon)
• NFL anytime touchdown scorer predictions Week 12 (coming soon)
• NFL first touchdown scorer predictions Week 12 (coming soon)
• NFL 2+ touchdown scorer predictions Week 12 (coming soon)
• NFL anytime touchdown scorer parlay Week 12 (coming soon)
• NFL long-shot parlay Week 12 (coming soon)

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