NFL Predictions Week 10: Best Bets & Odds for Every Game This Week
We've officially reached the halfway point of the regular season, and our NFL predictions for Week 10 break down the latest odds with our best bets and expert picks for every game this week - kicking off with Raiders vs. Broncos on Thursday Night Football all the way through Eagles vs. Packers on Monday Night Football.
🏈 NFL predictions for Week 10
See all of our NFL picks for every Week 10 game with the latest odds.
- Early Raiders vs. Broncos prediction
- Raiders vs. Broncos prediction (coming soon)
- Raiders vs. Broncos player props (coming soon)
- Raiders vs. Broncos same-game parlay (coming soon)
- Raiders vs. Broncos anytime touchdown scorer predictions (coming soon)
- Raiders vs. Broncos first touchdown scorer predictions (coming soon)
- Ashton Jeanty player prop bets (coming soon)
- Raiders vs. Broncos expert picks (coming soon)
- Early Falcons vs. Colts prediction
- Falcons vs. Colts prediction (coming soon)
- Falcons vs. Colts player props (coming soon)
- Falcons vs. Colts same-game parlay (coming soon)
- Falcons vs. Colts anytime touchdown scorer predictions (coming soon)
- Giants vs. Bears player props (coming soon)
- Bills vs. Dolphins player props (coming soon)
- Ravens vs. Vikings player props (coming soon)
- Browns vs. Jets player props (coming soon)
- Patriots vs. Buccaneers player props (coming soon)
- Saints vs. Panthers player props (coming soon)
- Jaguars vs. Texans player props (coming soon)
- Cardinals vs. Seahawks player props (coming soon)
- Rams vs. 49ers player props (coming soon)
- Lions vs. Commanders player props (coming soon)
- Early Steelers vs. Chargers prediction
- Steelers vs. Chargers prediction (coming soon)
- Steelers vs. Chargers player props (coming soon)
- Steelers vs. Chargers same-game parlay (coming soon)
- Steelers vs. Chargers anytime touchdown scorer predictions (coming soon)
- Steelers vs. Chargers first touchdown scorer predictions (coming soon)
- Justin Herbert player prop bets (coming soon)
- Steelers vs. Chargers expert picks (coming soon)
- Early Eagles vs. Packers prediction
- Eagles vs. Packers prediction (coming soon)
- Eagles vs. Packers player props (coming soon)
- Eagles vs. Packers same-game parlay (coming soon)
- Eagles vs. Packers anytime touchdown scorer predictions (coming soon)
- Eagles vs. Packers first touchdown scorer predictions (coming soon)
- Eagles vs. Packers expert picks (coming soon)
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💰 NFL odds & expert picks: Week 10
Live NFL odds for every Week 10 game from our best NFL betting sites.
📊 Raiders vs. Broncos odds
- Date: Thursday, Nov. 6
- Kickoff: 8:15 p.m. ET
- Location: Empower Field at Mile High (Denver)
- TV: Prime Video
🔮 Early Raiders vs. Broncos prediction
🐎 Broncos -9.5 (-110)
The Raiders have managed to avoid public scrutiny as perhaps the worst team in the NFL, but I don't expect them to keep pace with the surging Broncos, who should win a seventh straight contest with ease.
📊 Falcons vs. Colts odds
- Date: Sunday, Nov. 9
- Kickoff: 9:30 a.m. ET
- Location: Olympic Stadium (Berlin, Germany)
- TV: NFL Network
🔮 Early Falcons vs. Colts prediction
🐴 Colts -6.5 (-102)
It's nearly impossible to know what to expect from the Falcons on a weekly basis, but I feel pretty confident the Colts will be out for blood this week after a humbling loss to the Steelers last week. On paper, this isn't a close contest.
📊 Giants vs. Bears odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: Soldier Field (Chicago)
- TV: FOX
🔮 Early Giants vs. Bears prediction
🗽 Giants +3.5 (-110)
All of the attention this week is on the Bears' miraculous comeback, and rightfully so, but they also allowed 42 points to an injured Joe Flacco and Co. I like fading bad teams laying points, and Chicago just might be a bad team masquerading as a good one.
📊 Bills vs. Dolphins odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: Hard Rock Stadium (Miami Gardens, Fla.)
- TV: CBS
🔮 Early Bills vs. Dolphins prediction
🦬 Bills -8.5 (-108)
This feels like it could be one of the biggest blowout wins of the season, and I'm surprised the Bills aren't double-digit favorites against the listless Dolphins. I'll gladly bet on Buffalo at this favorable line until that changes.
📊 Browns vs. Jets odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: MetLife Stadium (East Rutherford, N.J.)
- TV: CBS
🔮 Early Browns vs. Jets prediction
✈️ Jets -1.5 (-115)
While their only win came against the imminently dysfunctional Bengals, I came away impressed by the Jets offense ahead of their bye week, which should help them cover the short number against a less inspired Cleveland attack.
📊 Saints vs. Panthers odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: Bank of America Stadium (Charlotte, N.C.)
- TV: FOX
🔮 Early Saints vs. Panthers prediction
🐾 Panthers -4.5 (-115)
Just when you think the Panthers will turn back into a pumpkin, they upset one of the best teams in the NFL. I don't want to buy too high here, but the Saints have their own issues and have lost by 12-plus points in all four of their road games.
📊 Ravens vs. Vikings odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: U.S. Bank Stadium (Minneapolis)
- TV: CBS
🔮 Early Ravens vs. Vikings prediction
🐦⬛ Ravens -3.5 (-102)
The Vikings came back to life this week in J.J. McCarthy's return in a shocking upset win over the Lions. But I'm still more impressed with what I've seen from the Ravens over the last three weeks - and especially last week in Lamar Jackson's own return to action.
📊 Patriots vs. Buccaneers odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: Raymond James Stadium (Tampa, Fla.)
- TV: FOX
🔮 Early Patriots vs. Buccaneers prediction
🪖 Patriots +2.5 (-105)
The Buccaneers felt like a team of destiny early in the year, though the good vibes faded when virtually all of their best skill-position stars went down. Even after a bye, Tampa Bay won't be whole in this matchup with a still-underrated Patriots team led by a true MVP candidate in Drake Maye.
📊 Jaguars vs. Texans odds
- Date: Sunday, Nov. 9
- Kickoff: 1 p.m. ET
- Location: NRG Stadium (Houston)
- TV: CBS
🔮 Early Jaguars vs. Texans prediction
🐆 Jaguars +1.5 (-110)
I'm assuming C.J. Stroud will be available for this matchup, but either way his injury isn't a great sign for a Texans offense that still can't quite find its rhythm. I'm willing to buy into the Jaguars for another week, though it's not among my most confident plays of the week.
📊 Cardinals vs. Seahawks odds
- Date: Sunday, Nov. 9
- Kickoff: 4:05 p.m. ET
- Location: Lumen Field (Seattle)
- TV: FOX
🔮 Early Cardinals vs. Seahawks prediction
🟢 Seahawks -6.5 (-115)
Seattle is one of the best teams in the NFL - full stop. Until the betting market starts treating the 'Hawks as a legitimate contender, I'll keep cleaning up at the window on Mike Macdonald's group against clearly inferior competition.
📊 Lions vs. Commanders odds
- Date: Sunday, Nov. 9
- Kickoff: 4:25 p.m. ET
- Location: Northwest Stadium (Landover, Md.)
- TV: CBS
🔮 Early Lions vs. Commanders prediction
🦁 Lions -3.5 (-112)
If you can still bet the Lions -3.5, do so immediately with Jayden Daniels set to miss time for the Commanders. I'd still play this up to -9.5 (you can get better than that anywhere right now), as Detroit's defense is still massively underrated and should feast on this Marcus Mariota-led group.
📊 Rams vs. 49ers odds
- Date: Sunday, Nov. 9
- Kickoff: 4:25 p.m. ET
- Location: Levi’s Stadium (Santa Clara, Calif.)
- TV: FOX
🔮 Early Rams vs. 49ers prediction
🐏 Rams -3.5 (-105)
It's easy to forget about the Rams when they aren't playing in prime time or drawing national headlines, but this group has quietly won three straight games by 14-plus points and should be extra motivated to get back at the 49ers after an overtime loss in Week 5.
📊 Steelers vs. Chargers odds
- Date: Sunday, Nov. 9
- Kickoff: 8:20 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- TV: NBC
🔮 Early Steelers vs. Chargers prediction
⚡️ Chargers -3 (-110)
We've seen this story before with Mike Tomlin-coached teams, and I simply refuse to believe in a midseason resurgence for Pittsburgh. I'll gladly buy low on the Chargers, who are the better football team on both sides of the ball and should take care of business.
📊 Eagles vs. Packers odds
- Date: Monday, Nov. 10
- Kickoff: 8:15 p.m. ET
- Location: Lambeau Field (Green Bay, Wis.)
- TV: ESPN
🔮 Early Eagles vs. Packers prediction
🧀 Packers -2.5 (-110)
It's certainly a tough look to lose to the Panthers at home - which we predicted could happen last week - but the Packers have been playing with their food all season. When the lights are brightest? Expect Jordan Love, Micah Parsons, and Co. to step up and frustrate these enigmatic Eagles.
💡 NFL expert picks for Week 10
Follow all of our NFL analysis for Week 10 throughout the week.
- NFL picks against the spread Week 10 (coming soon)
- NFL QB clutch player ratings Week 10 (coming soon)
- NFL survivor picks Week 10 (coming soon)
- NFL AI predictions Week 10 (coming soon)
- NFL weather report Week 10 (coming soon)
- NFL upset picks Week 10 (coming soon)
- NFL player props Week 10 (coming soon)
- NFL expert picks Week 10 (coming soon)
- NFL best bets Week 10 (coming soon)
- NFL moneyline picks Week 10 (coming soon)
- NFL anytime touchdown scorer predictions Week 10 (coming soon)
- NFL first touchdown scorer predictions Week 10 (coming soon)
- NFL 2x2 touchdown scorer predictions Week 10 (coming soon)
- NFL anytime touchdown scorer parlay Week 10 (coming soon)
- NFL Sunday same-game parlays Week 10 (coming soon)
- NFL long-shot parlay Week 10 (coming soon)
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