NFL Predictions for Week 18 Division Title Games | Odds, Best Bets for Title Matchups
Last Updated: December 29, 2025 5:30 AM EST • 2 minute read X Social Google News Link
Our NFL predictions for the Week 18 division title games offer real-time betting odds for each of the three title matchups while projecting the outcomes.
The NFL couldn't have drawn it up better, with the Tampa Bay Buccaneers and Carolina Panthers dueling for the NFC South crown in the early Saturday matchup, followed by the Seattle Seahawks duking it out against the San Francisco 49ers for the No. 1 seed and NFC West supremacy in prime-time. Bitter AFC North rivals, the Baltimore Ravens and Pittsburgh Steelers, culminate proceedings on Sunday Night Football, with the winner booking their playoff ticket. The analysis below is part of our NFL predictions for Week 18.
💰 NFL odds & expert picks for Week 18 division title games
Live NFL odds for every Week 18 game from our best NFL betting sites.
NFC South title matchup: Panthers vs. Buccaneers odds
- Date: Saturday, Jan. 3
- Kickoff: 4:30 p.m. ET
- Location: Raymond James Stadium (Tampa, Fla.)
- TV: ESPN/ABC
Early Panthers vs. Buccaneers prediction
🐈⬛ Panthers +3.5 (-115)
It's hard to get behind a Buccaneers team that is 1-7 in its last eight games, with a 1-3 mark at home and a 0-3 record versus NFC South opponents in that sample size. Via Gary Pearson's Panthers vs. Buccaneers prediction
NFC West title matchup: Seahawks vs. 49ers odds
- Date: Saturday, Jan. 3
- Kickoff: 8 p.m. ET
- Location: Levi's Stadium (Santa Clara, Calif.)
- TV: ABC/ESPN
Early Seahawks vs. 49ers prediction
⛏️ 49ers ML (-108)
The 49ers are 6-0 since Brock Purdy's return to the lineup, scoring at least 37 points four times. While they'll have their work cut out against a Seattle team with the league's best defensive DVOA, the 49ers offense is in peak form. Via Gary Pearson's Seahawks vs. 49ers prediction
AFC North title matchup: Ravens vs. Steelers odds
- Date: Sunday, Jan. 4
- Kickoff: 8:20 p.m. ET
- Location: Acrisure Stadium (Pittsburgh)
- TV: ESPN
Early Ravens vs. Steelers prediction
🐦⬛ Ravens -3 (-115)
Much of the Ravens' ability to cover the spread on the road will depend on whether Lamar Jackson plays. While that's still to be determined, I believe he'll be ready to go.The Ravens are 7-3 over the last 10 games, compared to the Steelers' subpar 5-7 mark in the previous 12. Via Gary Pearson's Ravens vs. Steelers prediction
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