NFL Playoff Odds | Divisional Round Look-Ahead Betting Lines & Matchups for Round 2

It's nearly time to anchor yourself in front of the largest screen you can find for playoff football, and if the excitement tied to the NFL predictions and wild-card matchups isn't enough, the NFL Divisional Round look-ahead odds have dropped now, too.

This is an opportunity to find value early, and to do so with mitigated risk. The results of Wild Card Weekend games will surely sway the lines below. So jump in early, and all bets void if your wager is tied to a matchup that doesn't happen.

🏈 Divisional Round look-ahead lines: NFC

NFL Divisional Round look-ahead odds via FanDuel.

Packers vs. Seahawks (-3.5)

The line for this next potential playoff clash between these rivals could shift depending on how Jordan Love looks in his return from a concussion after missing the team's final two games, though he was cleared to play in Week 18 and the team rested him.

Early pick: Packers +3.5

Eagles (-2.5) vs. Bears

It's looking like Rome Odunze will likely return for the Chicago Bears this week after logging some limited practice time. He's been out since Week 13 due to a foot injury, and any hope of upsetting the Eagles in a hostile road environment would rest with the league's ninth-ranked regular-season scoring offense boasting as many weapons as possible. We could see minor movement if he's locked in this weekend.

Early pick: Eagles -2.5

Rams (-1.5) vs. Eagles

The far more significant injury tied to a wide receiver is the hamstring ailment Davante Adams has been dealing with recently. Adams also missed the final two games of the regular season, and the league's leading red-zone scorer at his position showing he's fully healthy could budge a narrow line. Adams turned 34 red-zone targets this season into an NFL-best 10 touchdowns.

Early pick: Rams -1.5

Rams vs. Seahawks (-1.5)

Ditto for Adams here, and his fully healthy presence is even more impactful during the only hypothetical divisional-round matchup featuring the Rams that lists them as an underdog.

Early pick: Rams +1.5

49ers vs. Seahawks (-5.5)

Speaking of debilitating injuries, Trent Williams being out has been one of the most crushing late-season medical issues any team has faced. Both of the clashes this season between these bitter division rivals have been tight, but Seattle won 13-3 in Week 18 largely because the Seahawks eliminated San Francisco's rushing attack while holding Christian McCaffrey to 2.9 yards per carry. Williams isn't practicing yet, and his return would be massive.

Early pick: 49ers +5.5

49ers vs. Rams (-7)

The Rams cruised during the most recent edition of this divisional tilt, winning 42-26. However, that game featured Mac Jones under center for San Francisco. This spread is already teetering at the key number of 7, and it could shift below if Brock Purdy goes back to being an inferno. The likelihood of him being on fire is contributing to this game getting the highest total of all the hypothetical divisional-round matchups (53.5).

Early pick: 49ers +7

Rams (-4.5) vs. Bears

The Rams would need to travel to frosty Chicago here for what would be a mid-January game for a team that plays indoors. Los Angeles played four of its last five regular-season games in a dome environment, and the Windy City could be a sudden shift, especially if the forecast is ominous.

Early pick: Bears +4.5

🏈 Divisional Round look-ahead lines: AFC

See the latest NFL odds and our experts' NFL picks for every game this season.

Chargers vs. Broncos (-3)

Of all the hypothetical lines listed, this is the one to throw yourself at now. It could shift beyond just a field goal in the highly unlikely event the Chargers upset the New England Patriots on the road this weekend, and their offensive line is still incompetent in the process. An injury-decimated unit has put Justin Herbert, who's dealing with an injury of his own, under constant duress.

He's been sacked the third-most times leaguewide (54), including five in Week 17 against the Houston Texans, and a whopping seven in Week 14 against the Eagles.

Early pick: Broncos -3

Bills (-1.5) vs. Broncos

Josh Allen was also often under pressure this season while taking the seventh-most sacks (40). Traveling to Denver to face the league's fiercest pass rush is a daunting task. The Broncos finished first in sacks at 68, and there was a steep drop to the Atlanta Falcons at 57.

Jump now though if you're backing the Bills, as we could see movement if Allen truly looks mended after dealing with a foot injury.

Early pick: Broncos +1.5

Jaguars vs. Patriots (-1.5)

The Jaguars have won eight straight games, but many of those victories have come against struggling teams (the Tennessee Titans and Indianapolis Colts twice apiece, the New York Jets, and the Arizona Cardinals). Proving themselves against the Bills this weekend could give this line a boost in their direction.

Early pick: Jaguars +1.5

Texans vs. Patriots (-1.5)

If the Texans rise up as expected amid possibly tough weather on the road in Pittsburgh, this already tight line could budge their way. The NFL weather report for the Wild Card Round shows a frigid 32-degree forecast this weekend in Pittsburgh, but Houston is still a -2.5 road favorite.

Early pick: Texans +1.5

Texans vs. Broncos (-1.5)

The same is true here, and this would be a classic slugfest matchup featuring two of the league's top three scoring defenses. The Texans allow 17.4 points per game, while the Broncos aren't far behind at 18.3. Toss in the possibility of tough weather, and it's easy to see why this tilt is getting the lowest game total of all the hypothetical matchups (38.5, the only one under 41.5).

Early pick: Broncos -1.5

Steelers vs. Patriots (-5.5)

For all his impressive talents and production as an NFL MVP odds contender, Drake Maye takes a whole lot of sacks behind the Patriots' offensive line. He's been sacked the fourth-most times leaguewide (47), and here he'd be facing the Steelers' sixth-ranked pass rush (48 sacks). That's why T.J. Watt continuing to regain his form and get up to a full workload is key, possibly resulting in this line shuffling a bit toward Pittsburgh if the Steelers upset Houston. 

Early pick: Patriots -5.5

Steelers vs. Broncos (-4.5)

The Steelers' pass rush won't be the same factor here against Bo Nix, with the quality offensive line in front of him combined with his mobility leading to just 22 sacks. The Broncos can pick apart a 29th-ranked Pittsburgh secondary (243.9 yards allowed per game), and the confidence in that outcome could lead to this spread approaching a key number.

Early pick: Broncos -4.5

Bills (-1.5) vs. Texans

The Bills are 6-9 this season against the spread as a favorite, with their heavy clock-grinding lean on a top-ranked rushing offense playing a major role (159.6 yards per game). This spread is razor-thin here, but Buffalo's approach is important to keep in mind if there's movement.

Early pick: Texans +1.5

Texans vs. Jaguars (-2.5)

This is again a time when the Jaguars proving themselves in the playoffs and against a much higher caliber of competition could move the number toward them, especially with home-field advantage. The two division rivals split the season series, though both matchups ended in one-score affairs, with the winning team earning a seven-point victory each time.

Early pick: Texans +2.5

📊 Super Bowl odds

See the latest Super Bowl odds as The Big Game gets closer.

🤔 Is it worth betting on NFL Divisional Round look-ahead odds?

No matter how sharp the market seems, overreaction is often baked into betting odds. That's especially true during the playoffs when every matchup is under a spotlight and bettors are eager.

That's why betting early can prove advantageous, especially if you expect an upset that could sway the actual odds significantly. If that happens, you're already sitting on a far more appealing line.

But the best aspect is that risk is mitigated somewhat because all bets are voided if the matchup you're betting on doesn't happen, and your money is refunded.