NFL Picks Against the Spread: ATS Predictions for Every Week 18 Game
Last Updated: December 30, 2025 7:00 AM EST • 3 minute read X Social Google News Link
Our NFL picks against the spread for Week 18 focus on the Chicago Bears, Los Angeles Rams, and Philadelphia Eagles, two of which are guaranteed to have something to play for.
There's heaps to consider with so many variables at play in the final week of the season, so let us do the hard lifting. I've projected the outcome of every game on the slate as part of our NFL predictions for Week 18.
🏈 NFL picks against the spread: Week 18 ATS predictions
See all of our experts' NFL picks for Week 18 based on the latest NFL odds; pick confidence based on a 1-to-5-star scale.
| Matchup | Pick | Confidence |
|---|---|---|
| Lions vs. Bears (-2.5) | Bears (-2.5) | ⭐⭐⭐⭐⭐ |
| Cardinals vs. Rams (-7) | Rams (-7) | ⭐⭐⭐⭐ |
| Commanders vs. Eagles (-7.5) | Eagles (-7.5) | ⭐⭐⭐⭐ |
| Packers vs. Vikings (-6.5) | Vikings (-6.5) | ⭐⭐⭐⭐ |
| Dolphins vs. Patriots (-10.5) | Patriots (-10.5) | ⭐⭐⭐⭐ |
| Titans vs. Jaguars (-11.5) | Jaguars (-11.5) | ⭐⭐⭐⭐ |
| Cowboys (-4.5) vs. Giants | Cowboys (-4.5) | ⭐⭐⭐⭐ |
| Panthers vs. Buccaneers (-2.5) | Panthers (+2.5) | ⭐⭐⭐ |
| Seahawks (-1.5) vs. 49ers | 49ers (+1.5) | ⭐⭐⭐ |
| Saints vs. Falcons (-3) | Falcons (-3) | ⭐⭐⭐ |
| Browns vs. Bengals (-7.5) | Bengals (-7.5) | ⭐⭐⭐ |
| Colts vs. Texans (-10) | Texans (-10) | ⭐⭐⭐ |
| Chiefs (-5.5) vs. Raiders | Chiefs (-5.5) | ⭐⭐⭐ |
| Ravens (-3) vs. Steelers | Ravens (-3) | ⭐⭐⭐ |
| Jets vs. Bills (-7) | Bills (-7) | ⭐⭐⭐ |
| Chargers vs. Broncos (-11.5) | Broncos (-11.5) | ⭐⭐⭐ |
💰 Best ATS pick for Week 18
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 18.
Bears (-2.5) vs. Lions ⭐⭐⭐⭐⭐
While the rivalry is meaningful to fans regardless of the standings, Dan Campbell, no matter how much it irks him, will want to ensure his already banged-up team doesn't suffer any additional injuries to key personnel going into the offseason.
Plus, a loss will likely improve the team's draft pick.
Chicago, meanwhile, is playing for playoff positioning, which should provide more than enough incentive to win by a field goal. Ben Johnson and Co. will also want to prove how much they've progressed since losing to the Lions by 31 points at Ford Field in Week 2.
🔥 More Week 18 picks
Rams (-7) vs. Cardinals ⭐⭐⭐⭐
You could almost see the steam emitting from Sean McVay's ears after his team imploded on Monday Night Football against the Atlanta Falcons.
Even if the San Francisco 49ers win on Saturday, thereby rendering this matchup meaningless in the standings, McVay said all his healthy starters will play. While I find that hard to believe, I can get behind them to win by eight even if Jimmy Garoppolo starts.
They'll have something to prove after a putrid first half in Atlanta. Not only that, but the Rams will want to enter the playoffs firing on all cylinders, with restored confidence. That couldn't be more true for Matthew Stafford, whose MVP odds entering Week 18 are trading well behind Drake Maye.
Eagles (-7.5) vs. Commanders ⭐⭐⭐⭐
I love this matchup for Philly, which has something at stake: playoff positioning. I can't see Nick Sirianni resting anyone with the chance of securing the No. 2 seed still in play. While that scenario requires the Bears to lose to the Lions, stranger things have happened.
That added motivation will be more than enough for the defending Super Bowl champions to take care of business on home field, particularly on the back of an 11-point victory at the Commanders in Week 16.
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Gary Pearson X social