NFL Picks Against the Spread Today: Week 18 ATS Predictions
With only 14 remaining games in the 2025 regular season, our NFL picks against the spread provide a prediction for each of today's matchups, culminating with the AFC North title game on Sunday Night Football.
Included among those 14 predictions is a detailed analysis of three headlining matchups, part of the NFL predictions for Week 18. After the San Francisco 49ers lost to the Seattle Seahawks, all three featured games are meaningful in the standings.
🏈 NFL picks against the spread: Week 18 ATS predictions
See all of our experts' NFL picks for Week 18 based on the latest NFL odds; pick confidence based on a 1-to-5-star scale.
| Matchup | Pick | Confidence |
|---|---|---|
| Lions vs. Bears (-2.5) | Bears (-2.5) | ⭐⭐⭐⭐⭐ |
| Cardinals vs. Rams (-7) | Rams (-7) | ⭐⭐⭐⭐ |
| Commanders vs. Eagles (-7.5) | Eagles (-7.5) | ⭐⭐⭐⭐ |
| Packers vs. Vikings (-6.5) | Vikings (-6.5) | ⭐⭐⭐⭐ |
| Dolphins vs. Patriots (-10.5) | Patriots (-10.5) | ⭐⭐⭐⭐ |
| Titans vs. Jaguars (-11.5) | Jaguars (-11.5) | ⭐⭐⭐⭐ |
| Cowboys (-4.5) vs. Giants | Cowboys (-4.5) | ⭐⭐⭐⭐ |
| Panthers vs. Buccaneers (-2.5) | Panthers (+2.5) ✅ | ⭐⭐⭐ |
| Seahawks (-1.5) vs. 49ers | 49ers (+1.5) ❌ | ⭐⭐⭐ |
| Saints vs. Falcons (-3) | Falcons (-3) | ⭐⭐⭐ |
| Browns vs. Bengals (-7.5) | Bengals (-7.5) | ⭐⭐⭐ |
| Colts vs. Texans (-10) | Texans (-10) | ⭐⭐⭐ |
| Chiefs (-5.5) vs. Raiders | Chiefs (-5.5) | ⭐⭐⭐ |
| Ravens (-3) vs. Steelers | Ravens (-3) | ⭐⭐⭐ |
| Jets vs. Bills (-7) | Bills (-7) | ⭐⭐⭐ |
| Chargers vs. Broncos (-11.5) | Broncos (-11.5) | ⭐⭐⭐ |
💰 Best ATS pick for Week 18
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 18.
Bears (-2.5) vs. Lions ⭐⭐⭐⭐⭐
While the rivalry is meaningful to fans regardless of the standings, Dan Campbell, no matter how much it irks him, will want to ensure his already banged-up team doesn't suffer any additional injuries to key personnel going into the offseason.
Plus, a loss will likely improve the team's draft pick.
Chicago, meanwhile, is playing for playoff positioning, which should provide more than enough incentive to win by a field goal. Ben Johnson and Co. will also want to prove how much they've progressed since losing to the Lions by 31 points at Ford Field in Week 2.
🔥 More Week 18 picks
Rams (-7) vs. Cardinals ⭐⭐⭐⭐
You could almost see the steam emitting from Sean McVay's ears after his team imploded on Monday Night Football against the Atlanta Falcons.
The Rams will have something to prove after a putrid first half in Atlanta. Not only that, but the Rams will want to enter the playoffs firing on all cylinders, with restored confidence. That couldn't be more true for Matthew Stafford, whose MVP odds entering Week 18 are trading well behind Drake Maye.
And now that the 49ers lost, which impacted our Week 18 scenarios, the Rams will snag the No. 5 seed with a victory.
⬇️ How to bet NFL Week 18
Eagles (-7.5) vs. Commanders ⭐⭐⭐⭐
I love this matchup for Philly, which has something at stake: playoff positioning. I can't see Nick Sirianni resting anyone with the chance of securing the No. 2 seed still in play. While that scenario requires the Bears to lose to the Lions, stranger things have happened.
That added motivation will be more than enough for the defending Super Bowl champions to take care of business on home field, particularly on the back of an 11-point victory at the Commanders in Week 16.
Saquon Barkley, meanwhile, has a chance of receiving a nice little bump in his pay, which we outlined in our NFL contract incentives tracker.
💡 NFL expert picks for Week 18
Check out all of our NFL analysis and expert predictions for every game this season.
- NFL picks against the spread Week 18
- NFL AI predictions Week 18
- NFL weather report Week 18
- NFL upset picks Week 18
- NFL best bets Week 18
- NFL player props Week 18
- NFL anytime touchdown scorer predictions Week 18
- NFL first touchdown scorer predictions Week 18
- NFL 2+ touchdown scorer predictions Week 18
- NFL anytime touchdown scorer parlay Week 18
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