Patriots vs. Bills Parlay Picks for Sunday Night Football: SNF SGP at +470 odds

Last Updated: October 5, 2025 12:53 PM EDT • 3 minute read X Social Google News Link

My Patriots vs. Bills parlay picks for Sunday Night Football envision the Bills playing with their food a bit in this divisional rivalry. Our SNF parlay highlights the fact that New England hasn’t been a victim of a blowout yet this season.
The Patriots' elite run defense should also slow Buffalo's rushing attack as part of our NFL picks.
Our NFL predictions for Week 5 finish up while recognizing that Josh Allen will need to throw more if the Patriots keep this game close.
The action kicks off from Highmark Stadium in Orchard Park, N.Y., at 8:20 p.m. ET (NBC). The Bills are 8.5-point betting favorites.
🏈 Patriots vs. Bills parlay picks for Sunday Night Football
NFL parlay picks for Sunday Night Football; NFL odds subject to change.
- Patriots +8.5 (-115 via DraftKings) ⭐⭐⭐⭐
- James Cook Under 74.5 rushing yards (-111 via DraftKings) ⭐⭐⭐⭐
- Josh Allen Over 224.5 passing yards (-113 via DraftKings) ⭐⭐⭐⭐
Best odds: +470 via DraftKings ($10 to win $47)
💰 Best Sunday Night Football SGP bets
Here are my favorite Patriots vs. Bills picks based on the best Sunday Night Football odds for the full parlay.
🚀 Patriots +8.5 (-115) ⭐⭐⭐⭐
The Patriots have covered this spread in every game this season while going 2-2 against the spread overall and beating the margin by an average of plus-4.1 points per game. Buffalo is also 2-2 ATS, though with a slightly lesser ATS margin.
New England’s defense matches up well on the ground against Buffalo’s strength, which should keep the Patriots competitive in this game. On the other side, Mike Vrabel will surely commit to the ground game against Buffalo’s leaky run defense (164.3 yards per game, 31st in the NFL).
🚀 James Cook Under 74.5 rushing yards (-111) ⭐⭐⭐⭐
The team's rushing offense has been the bread and butter of Buffalo’s offensive success this season (163.5 yards per outing). But the Patriots allow an average of only 77.5 rushing yards per contest, ranking second in the NFL.
James Cook has cleared 100 rushing yards in three straight games, but his rushing line hasn’t been adjusted enough at the best sports betting sites to account for the opponent in this matchup.
To fit the expected game script correlating with our SGP, we’re siding with a Pats defense that has yet to allow a 50-plus-yard rusher this season.
🚀 Josh Allen Over 224.5 passing yards (-113) ⭐⭐⭐⭐
There will be more pressure on Josh Allen to throw if the Bills aren't as successful on the ground. That script fits what typically happens against the Patriots, too, as New England has allowed 241.5 passing yards per game (26th in the NFL).
Allen has only cleared this line once in four outings. But that falls in line with our prediction because we’re not expecting a blowout win like what Buffalo has produced the past three weeks when Allen has fallen short of cashing the Over on 224.5 passing yards.
While this outcome won't likely rival the Bills’ comeback win over the Ravens in Week 1 when he recorded a whopping 394 passing yards, the script for forcing Allen into the air more frequently should match it to a degree.
💰 Sunday Night Football SGP odds
Our parlay calculator shows the best odds for every market across legal sportsbooks in your area.
📺 How to watch Sunday Night Football
- Matchup: Patriots vs. Bills
- Date: Sunday,
- Kickoff: 8:20 p.m. ET
- Where: Highmark Stadium (Orchard Park, N.Y.)
- TV: NBC
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Brenden Schaeffer X social