Panthers vs. 49ers Same-Game Parlay for Monday Night Football: MNF Picks & SGP Odds
My Panthers vs. 49ers same-game parlay for Monday Night Football anticipates Carolina carrying on its impressive underdog energy for their point-spread backers. To fill out the rest of our MNF parlay, we’re leaning into trends that favor player props for both Bryce Young and Christian McCaffrey.
The action for Panthers vs. 49ers kicks off from Levi’s Stadium in Santa Clara, Calif., tonight at 8:15 p.m. ET (ESPN). The 49ers are 7.5-point betting favorites as part of our NFL predictions for Week 12.
✅ Panthers vs. 49ers same-game parlay for Monday Night Football
See all of our experts' NFL picks based on the latest NFL odds.
💵 Monday Night Football SGP bets
- 1st leg: Panthers +7.5 (-112) ⭐⭐⭐⭐
- 2nd leg: Bryce Young Over 209.5 passing yards (-112) ⭐⭐⭐⭐
- 3rd leg: Christian McCaffrey Over 5.5 receptions (-112) ⭐⭐⭐⭐
Best odds: +445 via DraftKings ($10 to win $44.50)
💰 Best Monday Night Football parlay picks & SGP bets
🚀 Panthers +7.5 (-112) ⭐⭐⭐⭐
The Panthers have been playing the plucky upstart role effectively this season while going 6-3 against the spread as an underdog. Carolina is also 4-2 ATS in road games on the year.
San Francisco is 1-3 ATS at home and 0-2 ATS as a home favorite. The 49ers suffered a 16-point defeat during their last home game against the Los Angeles Rams.
🚀 Bryce Young Over 209.5 passing yards (-112) ⭐⭐⭐⭐
One reason I believe in the Panthers keeping this matchup close is the struggles of the 49ers' pass defense. They rank 28th leaguewide while allowing 249.1 passing yards per game. Worse, San Francisco has permitted 302.0 passing yards per matchup over the team's last three outings.
Bryce Young isn't a model of consistency. But this line being at 209.5 yards is favorable considering Young is fresh off a career-high 448 passing yards against a top-10 pass defense last week in Atlanta.
Our Panthers vs. 49ers player props are locking in on Young, too.
🚀 Christian McCaffrey Over 5.5 receptions (-112) ⭐⭐⭐⭐
Christian McCaffrey is still a focal point of the 49ers' offense, and that includes his duties in the receiving game. He's racked up six-plus receptions in eight of 11 games played (72.7%) on the season, and now McCaffrey gets a favorable matchup for his contributions through the air to continue.
Only six teams have allowed more receptions to running backs this season than the Panthers (54 in 11 games).
💡 More NFL predictions
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📺 How to watch Monday Night Football: Panthers vs. 49ers
- Date: Monday, Nov. 24
- Kickoff: 8:15 p.m. ET
- Location: Levi’s Stadium (Santa Clara, Calif.)
- TV: ESPN
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