Packers vs. Bears Prediction & Opening Odds for Saturday Night Football: NFL Week 16

Saturday Night Football is in full force this week, and I'm dropping my best Packers vs. Bears prediction to get you set for kickoff.
Chicago Bears quarterback Caleb Williams - who's featured in my Bears vs. Packers prediction - during the game against the Green Bay Packers.
Pictured: Chicago Bears quarterback Caleb Williams - who's featured in my Bears vs. Packers prediction - during the game against the Green Bay Packers. Photo by: Jeff Hanisch-Imagn Images
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Let's dive into my Packers vs. Bears prediction on Saturday Night Football (ESPN) as the NFC North rivals battle it out for the division lead on prime time at Soldier Field with kickoff set for 8:20 p.m. ET. The opening odds have Green Bay as slight 1.5-point favorites. However, my early picks back Chicago in what should be an offensive struggle for both sides. 

Fire up your NFL predictions for Week 16 with us, and let's continue to cash down the stretch run.


🏈 Early Packers vs. Bears prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 16.

Chicago Bears moneyline (+110)⭐⭐⭐⭐

The Bears have won six of their last seven games and are absolutely rolling, demolishing Shedeur Sanders and the Cleveland Browns 31-3 last week. Chicago has the second-best rushing defense in the NFL over the last three games, and the offense will be getting a Packers defense without Micah Parsons after suffering a non-contact knee injury in Week 15. Ride Chicago as part of our best Bears vs. Packers predictions.

At +110 betting odds, you're getting a 47.62% chance this play hits, with a $10 wager returning $11. Let's kick off the week with a nice plus-money cash.

💡 More Week 16 predictions

Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 16.


📊 Live Packers vs. Bears odds: Week 16

See the latest NFL odds for every game in Week 16.

Packers vs. Bears opening odds

  • Moneyline: Packers -130 | Bears +110
  • Spread: Packers -1.5 (-110) | Bears +1.5 (-110)
  • Over/Under: Over 46.5 (-115) | Under 46.5 (-105)

Packers vs. Bears line movement

This line was initially Bears +3, but moved following Parsons' injury. I still love the value we're seeing on the moneyline here, and would grab it at plus-money before the favorite flips to Chicago. We're seeing 55% of the wagers already coming in on the Bears, so get your bets in before it's too late.


📈 Packers vs. Bears trends & betting notes: Saturday Night Football

  • Bears have lost 12 of their last 13 games vs. the Packers
  • Chicago is 9-5 against the spread this season - the third best mark in football
  • Green Bay is 6-8 ATS
  • 55% of wagers are on the Bears so far, with the spread slowly flipping toward Chicago becoming the favorite

📺 How to watch Packers vs. Bears: Saturday Night Football

  • Date: Saturday, Dec. 20, 2025
  • Kickoff: 8:20 p.m. ET
  • Location: Soldier Field (Chicago, IL)
  • TV: ESPN

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