NFL Moneyline Picks Week 8: Best Bets to Win Every Game This Week

My best NFL moneyline picks focus on three underdogs, though I’d only consider one of my NFL picks a true upset. Eight of this weekend’s 12 games feature point spreads of six points or more, meaning there is almost no value in taking favorites unless you’re adding them to parlays.

Below, I pick winners for all 12 games that remain this week, highlighting why three teams in particular can win their matchups. For more on this weekend’s slate, check out our NFL predictions for Week 8.

🏈 NFL moneyline picks: Week 8

NFL moneyline picks based on the latest NFL odds and subject to change; pick confidence based on a 1-to-5-star scale.

💰 My best Week 8 moneyline picks

Track the latest NFL scores for line movement and matchup info.

🐾 Panthers (+290) vs. Bills ⭐⭐

Bryce Young isn’t going to play in this game, but the Panthers get to turn to veteran Andy Dalton, so it won’t be much of a drop-off at the position. Plus, Panthers’ quarterback play isn’t going to matter much in this game, as the Bills rank 31st against the rush and are allowing 5.8 yards per carry, dead last in the NFL.

The Panthers have the third-best rushing attack in football, averaging 140.1 yards per game. Rico Dowdle has at least 79 yards in three consecutive games, and Chuba Hubbard is healthy, making this a very effective split backfield. 

And finally, the Panthers are solid defensively, as they rank 10th in pass defense and eighth in rush defense. Good defense and a solid rushing attack create a solid recipe for a home upset over a team not playing to its potential.

🤠 Cowboys (+150) vs. Broncos ⭐⭐⭐

The Broncos scored 33 points in last week’s fourth quarter, but in their seven quarters before that one, they managed just 11 points against the Jets and Giants. While the Cowboys rank 30th in scoring defense, the Broncos rank just 17th in scoring offense.

The Cowboys are averaging 31.7 points per game, second-most in the league, and they’ve managed at least 40 points three times already this season. Dak Prescott and the Cowboys’ passing attack rank second in the NFL with 268.4 yards per game.

While the Broncos rank sixth in pass defense, allowing just 179.9 yards per game, those numbers are greatly skewed thanks to the Jets’ -10 yard performance. The Broncos have allowed four 280-yard passers this season, which means this isn’t as bad of a matchup for Prescott as it may seem.

🏗️ Steelers (+140) vs. Packers ⭐⭐⭐⭐

The Packers are a completely different team on the road than they are at home. They’re 1-1-1 in road contests, despite not playing a team with a winning record, and their one win came last week against the Cardinals in very unconvincing fashion.

Meanwhile, the Steelers are 2-1 at home, and they have one of the best red zone defenses in the league. Opponents are scoring touchdowns on just 47.83% of red zone chances against the Steelers, and when the Steelers play at home, that number drops to 33.33%.

The Steelers don’t do anything that well offensively, as they are averaging the ninth-fewest yards per game (297.5). But the defense is tied for the fifth-most turnovers in the NFL (10), which has given the offense favorable field position all season long. Two of the Packers' three turnovers this season have been in road games.