NFL Moneyline Picks Week 3: Best Bets to Win Every Game This Week

Last Updated: September 18, 2025 8:21 AM EDT • 5 minute read X Social Google News Link

Looking for some NFL moneyline picks to sink your teeth into as you get prepared for Week 3 action?
The NFL picks below, part of the NFL predictions for Week 3, provide a recommendation for each game while featuring three headline contests. In the Week 2 long-shot parlay, my moneyline picks went 13-3.
🏈 NFL moneyline picks: Week 3
NFL moneyline picks based on the latest NFL odds and subject to change; pick confidence based on a 1-to-5-star scale.
Matchup | Pick | Confidence |
---|---|---|
Dolphins vs. Bills | Bills (-820) | ⭐⭐⭐⭐⭐ |
Packers vs. Browns | Packers (-390) | ⭐⭐⭐⭐⭐ |
Saints vs. Seahawks | Seahawks (-390) | ⭐⭐⭐⭐⭐ |
Chiefs vs. Giants | Chiefs (-270) | ⭐⭐⭐⭐⭐ |
Broncos vs. Chargers | Chargers (-156) | ⭐⭐⭐⭐ |
Rams vs. Eagles | Eagles (-186) | ⭐⭐⭐⭐ |
Jets vs. Buccaneers | Buccaneers (-320) | ⭐⭐⭐⭐ |
Bengals vs. Vikings | Vikings (-154) | ⭐⭐⭐⭐ |
Lions vs. Ravens | Ravens (-240) | ⭐⭐⭐⭐ |
Falcons vs. Panthers | Falcons (-250) | ⭐⭐⭐ |
Steelers vs. Patriots | Steelers (-130) | ⭐⭐⭐ |
Colts vs. Titans | Colts (-210) | ⭐⭐⭐ |
Cowboys vs. Bears | Cowboys (-108) | ⭐⭐⭐ |
Raiders vs. Commanders | Raiders (+138) | ⭐⭐ |
Texans vs. Jaguars | Jaguars (-146) | ⭐⭐ |
Cardinals vs. 49ers | Cardinals (+120) | ⭐⭐ |

💰 My best Week 3 moneyline picks
Track the latest NFL scores for line movement and matchup info.
⚡️ Chargers (-156) vs. Broncos ⭐⭐⭐⭐

Ultimately, Justin Herbert will be judged on whether he can get his act together in the playoffs. But for now, I'm all aboard the Herbert train.
Not only is he among the most clutch QBs entering Week 3, but he's also third in total QBR (81.6).
I also backed the Los Angeles Chargers in my against-the-spread picks. They had no trouble dispatching the Las Vegas Raiders on the road despite making some unnecessary mistakes in the second half.
The Denver Broncos, meanwhile, threw away what looked like an assured victory in Indianapolis. Their defense looked vulnerable against Daniel Jones in the air and was shredded on the ground by Jonathan Taylor, who had 165 yards on 25 carries.
While they scored 28 points in that game, I'm not convinced by their offense. That unit is ranked 19th in terms of offensive DVOA through two weeks.
The best sports betting sites reached a consensus, with the Chargers receiving -155 odds. You'll receive a $6.45 profit on a winning $10 bet.
🟣 Vikings (-154) vs. Bengals ⭐⭐⭐⭐

It's a matchup the public wants about as much as increased taxes, with Carson Wentz squaring off against Jake Browning.
While those starters won't be mistaken for NFL MVP odds contenders anytime soon, I'm all over backing the Minnesota Vikings at home, especially after that dismal display against the Atlanta Falcons in prime time.
Andrew Van Ginkel, arguably their most impactful defender, should play after missing Week 2 in concussion protocol.
He will galvanize that unit, which should make life untenably uncomfortable for Browning, who tossed three picks despite mounting one of the more unlikely comebacks last week against the Jacksonville Jaguars.
Browning will be elated with the last-gasp win against the Jaguars, but I'll take my chances with Wentz, who, despite not having meaningful playing time since 2022, is the more seasoned and reliable signal-caller.
That advantage makes the Vikings superior on both sides of the ball. At -154, FanDuel offers the best value, where a winning $10 bet will yield a $6.49 profit. DraftKings (-175) provides the least value.
🦅 Eagles (-186) vs. Rams ⭐⭐⭐⭐

Playing a proficient Los Angeles Rams team at home after securing a second straight win against the Kansas City Chiefs could represent a letdown spot for the Super Bowl champs.
The Rams, who are 7-0 ATS in their previous six away games, including last season's playoff loss to Philly, will probably give the Eagles everything they can handle.
However, covering the spread and winning outright are two entirely different kettles of fish.
The Eagles have so many weapons, and their defense, as expected, looks like the elite unit most people thought it would be with Jalen Carter's disruptive presence.
Philadelphia is arguably the best team in the league at time and game management. They grind and grind like no other, possessing a quintessentially championship quality that enables them to win when they're not at their best.
Add home-field advantage and Jalen Hurts' 16-0 record in his last 16 starts, and the Eagles should have enough to get past the stubborn visitors. The Eagles' moneyline odds range from -180 to -190, with Caesars offering the best value.
If you're looking for a contrarian viewpoint, check out Mike Spector's upset picks for Week 3.
❓ NFL moneyline picks FAQs
What are the best NFL moneyline picks this week?
My best three moneyline picks are: Chargers (-156), Vikings (-154), Eagles (-186).
What does the moneyline mean in NFL?
The "moneyline" in the NFL is for betting on a team to win outright, and the return on your bet is determined by the moneyline odds - which are calculated based on the return for a $100 bet. For example, if a team has moneyline odds of +120, then a $100 bet would return a $120 profit. Conversely, if a team has moneyline odds of -120, then a $120 bet would return a $100 profit.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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