MNF Parlay Picks & Predictions: Monday Night Football SGP Odds

Our Monday Night Football parlay picks and predictions build a three-leg parlay with +448 odds around the passing yardage totals of two quarterbacks playing tonight.

Brenden Schaeffer

Last Updated: September 15, 2025 2:35 PM EDT • 4 minute read

MNF Parlay Picks & Predictions: Monday Night Football SGP Odds — Pictured: Las Vegas Raiders quarterback Geno Smith (7) drops back to pass. Photo by Brian Fluharty via Imagn Images.

We've got a doubleheader tonight, and my Monday Night Football parlay picks and predictions are targeting an edge on C.J. Stroud’s passing yardage total that leans into the strengths and weaknesses of the Tampa Bay defense.

Then we’re taking our MNF parlay into Game 2, where we’ve compiled a correlated stack of the Raiders' offense to cap off our NFL predictions for Week 2.

The Buccaneers vs. Texans game kicks off at 7 p.m. ET from NRG Stadium in Houston, where the Texans are a 2.5-point betting favorite. The Chargers vs. Raiders game kicks off at 10 p.m. ET from Allegiant Stadium in Las Vegas, where the Chargers are a 3.5-point betting favorite.

Our NFL picks for Monday night combine for a three-leg parlay with odds of +448 at DraftKings.

🏈 Best Monday Night Football parlay picks

NFL parlay picks for Monday Night Football; NFL odds subject to change.

C.J. Stroud Over 227.5 passing yards (-112 via DraftKings) ⭐⭐⭐⭐
Geno Smith Over 241.5 passing yards (-113 via DraftKings) ⭐⭐⭐⭐⭐
Tre Tucker Over 29.5 receiving yards (-111 via DraftKings) ⭐⭐⭐⭐

Best parlay odds: +448 via DraftKings ($10 to win $44.80)

💰 Best Monday Night Football SGP bets

Here are my favorite Monday Night Football picks based on the best Monday Night Football odds for the full parlay.

🚀 C.J. Stroud Over 227.5 passing yards (-112) ⭐⭐⭐⭐

Is Tampa Bay’s secondary bad? Because Atlanta Falcons quarterback Michael Penix Jr. unloaded for 298 passing yards in a Week 1 loss to the Bucs but dinked and dunked for just 135 yards on Sunday Night Football in Week 2.

While the game script called for the Falcons to run the rock against Minnesota, the result does highlight a potential deficiency in Tampa’s defense.

Texans signal-caller C.J. Stroud mustered just 188 passing yards on the road against a quality Rams defense in Week 1, but given how well the Bucs stuffed a quality Atlanta rushing attack last week (22 RB carries for 48 yards), Stroud will be forced to air it out on MNF. His DraftKings line at 227.5 passing yards feels like a misprice.

🚀 Geno Smith Over 241.5 passing yards (-113) ⭐⭐⭐⭐⭐

It sounds crazy, but Raiders quarterback Geno Smith might be better positioned to exploit NFL secondaries at this moment than Patrick Mahomes is. Smith put on an absolute clinic against New England last weekend, with 362 passing yards while dropping dimes all over the field.

Despite the challenges in the Chiefs' WR room, which were evident again in Week 2, Mahomes racked up a respectable 258 passing yards against the Chargers' defense in the season opener.

I don’t see why Smith, in a projected negative game script, shouldn’t have plenty of opportunities to compile numbers on MNF.

🚀 Tre Tucker Over 29.5 receiving yards (-111) ⭐⭐⭐⭐

Correlating to Smith’s passing yardage going Over, I like Las Vegas wideout Tre Tucker to connect with Geno on a deep ball or two on Monday night.

Tucker hauled in two receptions for 54 yards in the opener and is a sneaky deep threat when defenses focus so much attention on Brock Bowers, Ashton Jeanty, and Jakobi Meyers.

Normally, correlation like this in SGPs provides very little odds boost for the parlay, but since we have a prop from a second MNF game involved, we’re still getting solid odds of +448 from DraftKings.

💰 Best Monday Night Football SGP odds

Our parlay calculator shows the best odds for every market across legal sportsbooks in your area.

📺 How to watch Monday Night Football

When: Monday, Sept. 15
Kickoff: 7 p.m. ET and 10 p.m. ET
Where: NRG Stadium (Houston) and Allegiant Stadium (Las Vegas)
How to watch: ABC/ESPN

❓NFL parlay betting FAQs

What is a parlay bet in the NFL?

A parlay combines multiple bets (spreads, totals, props, or moneylines) into one wager, with all selections needing to win for the bet to cash. Parlays are popular in the NFL betting because they offer bigger payouts.

How do NFL parlay odds work?

Parlay odds are calculated by multiplying the odds of each individual selection, which increases both the potential payout and the risk. The more legs you add, the higher the reward but the lower the probability of winning.

Are parlays a smart betting strategy for the NFL?

Parlays can be fun for chasing large payouts but are harder to win consistently. Many sharp bettors prefer single-game wagers, but NFL parlay bets can add excitement when used responsibly.

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written by:
Brenden Schaeffer

Brenden has covered the St. Louis Cardinals as a credentialed baseball writer for KMOV-TV since 2016. His sports writing has appeared in outlets including the Austin American-Statesman and Columbia Daily Tribune. Since 2021, Brenden has co-hosted 'The Big Show' during the afternoon drive for KTGR, the ESPN radio affiliate in Columbia, MO. He has appeared on radio stations around the country, including KMOX, and hosts a daily St. Louis Cardinals podcast. In the sports betting content space, Brenden has covered the NFL, college football, NBA, and college basketball for outlets including SBR since 2019. For his football handicapping, Brenden looks to target player prop markets using his NFL experience, as well as sharp underdog lines in college football. Brenden looks to reference FanDuel for his sports betting articles because of its consistently competitive odds on parlays. FanDuel's boost offerings are also customer-friendly, and its odds on the NFL Same Game Parlay articles he's written for SBR have historically been consistently competitive compared to other books.