NFL Midseason Predictions: Three Futures Bets to Make Right Now

The 2025 season is absolutely flying by - it's time to slow down and smell the roses, and by that I mean make our three best NFL midseason predictions in the futures market. From the Super Bowl champion to MVP to Defensive Rookie of the Year, I'm dropping my favorite futures bets you have to make right now.

📊 NFL midseason predictions

Latest NFL odds updated live in real time from our best NFL betting sites.

Super Bowl prediction: The case for the Buffalo Bills (+650)

The one thing I was worried about was the Bills' defense holding them back from greatness, but wow, did they look great in Week 9 against the Kansas City Chiefs - especially Joey Bosa. The defensive end was a pure game-breaker, logging three tackles, two tackles for loss, five QB hits, and one sack. Patrick Mahomes was on his derriere all game long, and it's because Bosa finally made his presence felt on that front-seven when they needed it most, recording sacks in consecutive weeks.

After pushing their record to 6-2, they've got a pretty easy schedule the rest of the way, which should set them up for an AFC East title and a bye into the divisional round. With games against the Miami Dolphins, Cincinnati Bengals, Cleveland Browns, and New York Jets on tap, the Bills will not only cruise into the playoffs but also finally get over the hump and beat Mahomes in the AFC Championship Game. They've found the blueprint, and at +650 Super Bowl odds, the payout is worth the risk. Here's to hoping they add a receiver at the deadline for Josh Allen, too.

📊 Super Bowl odds

NFL MVP prediction: Is Matthew Stafford really an option? (+500)

Yes, yes he is.

At 37 years old, Stafford has just as good a chance as anyone on the NFL MVP odds board to win it. Not only does he have the Rams in a prime spot to win the hardest division in football this year, but he's arguably putting forth his best season to date.

Stafford is leading the NFL in passing touchdowns with 21 - he's thrown just two interceptions - and is in the top five in passing yards, yards per game, passer rating, and has the longest touchdown at 88 yards. He's almost never been in a better spot, too, with Puka Nacua, Davante Adams, a strong offensive line, and a quality running back duo in Kyren Williams and Blake Corum rounding out his supporting cast. He's got the weapons and a handful of big games remaining against the Seattle Seahawks and Detroit Lions on deck to bolster his case.

You might not see this price again, with a $10 wager netting you $50 in profit. It's time to make this NFL MVP bet right now.

NFL Defensive Rookie of the Year prediction: Tap Jihaad Campbell now (+320) 

I've been pounding the table for Campbell since Week 2. His preseason Defensive Rookie of the Year odds of +1800 are now sitting at +320 - and you still might be getting a bargain here. In my opinion, Campbell has outperformed Abdul Carter from the jump this season and continues to play a large role on that Philadelphia Eagles defense.

Not only is Campbell quite the cerebral linebacker this year, but he's also been incredible in coverage - whether he's against a wideout or tight end, they simply can't get separation. 

PFF grades Campbell first among all defensive rookies and fifth among all linebackers in the league (83.1). 

Carter, who's the favorite, has recorded just 0.5 sacks all year. That begs the question, how much longer will he remain on top? It won't be long - take Campbell before it's too late.

A $10 wager here nets $32, and I'd play this all the way down to +250.