Lions vs. Ravens Prediction, Monday Night Football Odds & MNF Picks

Last Updated: September 21, 2025 4:00 PM EDT • 5 minute read X Social Google News Link

The Baltimore Ravens host the Detroit Lions at M&T Bank Stadium (8:15 p.m. ET, ESPN) for Monday Night Football as I offer my Lions vs. Ravens prediction.
The Ravens are the 4.5-point betting favorite (-105), but I'm more interested in the total (52.5 points), expecting the Over to hit in an explosive evening for both offenses in Baltimore.
The picks below are part of the NFL picks, which complement our NFL predictions for Week 3.
🏈 Lions vs. Ravens prediction for Monday Night Football
NFL expert picks based on the latest Monday Night Football odds; subject to change.
- Moneyline pick: Ravens (-225 via Caesars) ⭐⭐⭐
- Against the spread pick: Ravens -4.5 (-108 via DraftKings) ⭐⭐⭐
- Over/Under pick: Over 52.5 (-115 via FanDuel) ⭐⭐⭐⭐

📝 Monday Night Football best bet
Track the latest NFL scores for line movement and matchup info.
⬆️ Over 52.5 (-115) ⭐⭐⭐⭐

The Ravens scored the third-most points per game at home last season (31.1) and have averaged 34 per game at M&T Bank Stadium in the last eight regular-season home games. In seven of those games, they scored at least 30, with the lone exception a 19-point output against the reigning Super Bowl champion Philadelphia Eagles.
To further reinforce their status as an offensive powerhouse, Baltimore has the second-best offensive DVOA and best EPA per play through two games.
I won't harp on about the Lions' 52-point offensive explosion against the Chicago Bears, as it occurred at home against a defense much worse than the Ravens'.
I'll instead focus on the absences of Ravens' Pro Bowl pass rushers Nnamdi Madubuike (neck) and linebacker Kyle Van Noy (hamstring), who combined for 19 of the team's 53 sacks last season. Noy had the most (12.5) and Madubuike the third-most (6.5).
That's the best possible news for Lions QB Jared Goff, as he had the second-best passer rating (120) last season of QBs with at least 100 dropbacks with no pressure. So far this season, he is fourth on that list (129.5).
While Detroit's offense is still ostensibly unproven on the road under offensive coordinator John Morton, the conditions are ripe for a productive evening.
FanDuel is the only one of the best sports betting sites offering the lower 52.5 option. You don't have to pay up the wazoo, either, with the -115 odds just slightly shorter than the higher total of 53.5 offered at BetMGM (-110) and DraftKings (-112).
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💰 Best Lions vs. Ravens player prop bet for Monday Night Football
Our NFL player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Jared Goff Over 260.5 passing yards (-114) ⭐⭐⭐⭐

Based on the Ravens' aforementioned defensive absences (Noy and Madubuike), I'm confident in backing Goff to amass at least 261 passing yards. Goff hit the Over on that number in seven of the previous 10 regular-season games, including three of the last four on enemy terrain.
Goff, who benefits more than most from an extra second in the pocket, should have enough time to pick out his multiple weapons. And if the game script goes as I envision, the Lions will be chasing the game in the fourth quarter. That might force Morton's hand, making him air it out more frequently.
Although FanDuel offers the lowest total (260.5 yards), it doesn't overcompensate by charging a ridiculous price (-114), still offering the second-best odds. BetMGM has the highest total (263.5 yards), offering -115 odds.
A winning $10 bet at FanDuel would yield an $8.70 profit.
📊 Lions vs. Ravens odds: MNF
NFL odds update live in real time.
📈 Lions vs. Ravens opening odds
- Moneyline: Lions +200 | Ravens -250
- Spread: Lions +5.5 (-110) | Ravens -5.5 (-110)
- Over/Under: Over 51.5 (-110) | Under 51.5 (-110)
🔍 Lions vs. Ravens odds analysis
The total is set between 52.5 and 53.5 points. FanDuel is the only one of the best sports betting apps offering 52.5. Its total should increase to 53 or 53.5 in the lead-up to kickoff, which aligns with the others. I wouldn't play anything higher than 53.5. The Ravens' spread decreased from -5.5 to -4.5. With the odds between -105 and -115, I don't see any further shift occurring.
🔢 Lions vs. Ravens stats
Season stats courtesy of Pro Football Reference.
Lions (1-1) | Statistic (per game) | Ravens (1-1) |
---|---|---|
32.5 | Points | 40.5 |
24 | Points allowed | 29 |
+0.5 | Turnover margin | +0.5 |
267 | Passing yards | 195.5 |
111.5 | Rushing yards | 141.5 |
196.5 | Passing yards allowed | 298 |
106 | Rushing yards allowed | 111.5 |
0.7 | Net yards per play | 1 |
🚑 Lions vs. Ravens injury report
📺 How to watch Monday Night Football
- When: Monday, Sept. 21
- Kickoff: 8:15 p.m. ET
- Where: M&T Bank Stadium (Baltimore)
- How to watch: ESPN/ABC
❓ Monday Night Football FAQs
Who plays on Monday Night Football?
The Baltimore Ravens host the Detroit Lions for Monday Night Football.
When is Monday Night Football?
MNF starts at 8:15 p.m. ET (ABC/ESPN).
Who is favored to win Monday Night Football?
The Baltimore Ravens are the 4.5-point betting favorite against the visiting Detroit Lions.
How do NFL odds work?
When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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Gary Pearson X social