Lions vs. Chargers Expert Picks & NFL Predictions: Hall of Fame Game 2025

We've gathered all of our best picks and predictions for the NFL preseason opener tonight in Canton, Ohio.

Last Updated: July 31, 2025 6:08 PM EDT • 4 minute read

Lions vs. Chargers Expert Picks & NFL Predictions: Hall of Fame Game 2025 — Pictured: General view of the logo at mid-field at the Tom Benson Hall of Fame Stadium. Photo by Charles LeClaire / Imagn Images.

The NFL Hall of Fame Game kicks off tonight at 8 p.m. (NBC) as the Detroit Lions and Los Angeles Chargers battle at Tom Benson Hall of Fame Stadium in Canton, Ohio.

We've gathered all of our best Lions vs. Chargers expert picks from our NFL expert Gary Pearson, who is siding with Detroit as a 1.5-point betting favorite across the best sports betting sites to win the NFL preseason opener tonight.

You can also check out our NFL preseason betting guide for tips on betting this game and the entire NFL preseason.

🏈 Lions vs. Chargers expert picks

🔎 Our NFL player prop odds tool can help you find the best NFL odds to make your NFL picks across legal sportsbooks in your region.

Against the spread pick: Lions -1.5 (-110 via BetMGM) ⭐⭐⭐
Best O/U total pick: Over 32.5 (-115 via FanDuel) ⭐⭐⭐
Best Lions prop bet pick: Chargers Over 0.5 passing TDs (-130 via FanDuel) ⭐⭐⭐⭐
Best Chargers prop bet pick: Lions 200+ receiving yards (-128 via FanDuel) ⭐⭐⭐⭐

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✅ Lions vs. Chargers ATS prediction

Here's a brief look at why Pearson is betting on Lions -1.5 as his best prediction against the spread for the Hall of Fame Game:

"A ton has been made of the early volatility at Detroit's training camp, with Campbell having to step in multiple times to break up scraps. That agitation and amped competitiveness might spill over into the Hall of Fame Game, which could give the Lions an edge."

👉 For full analysis, check out our Lions vs. Chargers prediction

↕️ Lions vs. Chargers Over/Under prediction

Here's a brief look at why Pearson is backing Over 32.5 as his best prediction for the total ahead of the Hall of Fame Game:

"I'm leaning toward the Over as the Lions will want to further evaluate )Hendon) Hooker and (Kyle) Allen. Additionally, Jahmyr Gibbs and David Montgomery are unlikely to feature. That should lead to an increased number of pass attempts, hopefully facilitating scoring chances."

👉 For full analysis, check out our Lions vs. Chargers prediction

🦁 Best Lions prop bet

Here's a brief look at why Pearson expects the Lions to record 200+ receiving yards in the Hall of Fame Game:

"With Hooker and Allen battling for the backup job, I expect the Lions to deploy a pass-heavy attack. Dan Campbell will give both signal-callers enough reps to leave a lasting impression in their preseason opener, which should help get receivers more involved."

👉 For full analysis, check out our best Lions vs. Chargers team props

⚡ Best Chargers prop bet

Here's a brief look at why Pearson expects the Chargers to record Over 0.5 passing touchdowns in the Hall of Fame Game:

"With Taylor Heinicke not expected to feature, (Trey) Lance should get at least the first half to showcase his best stuff. The third QB spot is up for grabs, so motivation won't be an issue."

👉 For full analysis, check out our best Lions vs. Chargers team props

🚀 Best Lions vs. Chargers SGP

Lions -1.5 (-110) ⭐⭐⭐
Over 32.5 (-115) ⭐⭐⭐
Lions 200+ receiving yards (-128) ⭐⭐⭐⭐

📊 Combined odds: +536 via FanDuel | Implied probability: 15.72%

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📊 Lions vs. Chargers odds

📈 Lions vs. Chargers betting insights

Here are the latest Lions vs. Chargers betting insights via BetMGM as of Thursday afternoon, including the percent of total bets placed on each side:

Team	Spread	Moneyline	Total
Lions	66% (-1.5)	49% (-125)	70% (Over 33.5)
Chargers	34% (+1.5)	51% (+105)	30% (Under 33.5)

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Written by:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.