Giants vs. Patriots Prediction & Opening Odds for Monday Night Football: NFL Week 13

My Giants vs. Patriots prediction addresses the opening odds that sees New England as a hefty home favorite as they continue to push for top billing in the AFC Playoff picture. Our early picks try to bake in the potential for Jaxson Dart to return from a concussion while understanding that Jameis Winston could still be under center for New York in this matchup.

The action for Giants vs. Patriots kicks off from Gillette Stadium in Foxborough, Mass., Monday, Dec. 1, at 8:15 p.m. ET (ESPN). The Patriots are 7.5-point betting favorites as part of our NFL Week 13 predictions.

🏈 Early Giants vs. Patriots prediction & betting preview

Stay ahead with the rest of our early NFL picks for Week 13.

🗽Giants +7.5 (-115) ⭐⭐⭐

Jaxson Dart missed his second game in a row in Week 12 in the concussion protocol. Although these circumstances could conceivably linger into this Week 13 matchup, it’s not particularly common to see a player miss three straight weeks for a concussion.

If news emerges throughout the week that Dart is expected to return for MNF, I wouldn’t expect the -105 odds on Patriots -7.5 to hold - we could see the spread move toward the Giants later in the week if positive Dart updates arrive. It's also enough of a reason to avoid the heavily-favored Patriots in our Week 13 NFL Survivor pool picks.

We're jumping on this number early in the week, as I would play Giants +7.5 regardless of whether it's Dart or Jameis Winston. New York is 4-3 ATS with Dart starting and 2-0 ATS behind Winston. DraftKings lists Giants +7.5 with -115 odds. That equates to an implied probability of 53.49%. A winning $10 wager would profit $8.70.

This number is one our Gary Pearson backs in his NFL Week 13 ATS predictions.

More Giants vs. Patriots picks for Monday Night Football 

📊 Live Giants vs. Patriots odds: Week 13

See the latest NFL odds for every game in Week 13.

🔢 Giants vs. Patriots opening odds

• Moneyline: Giants +325 | Patriots -425
• Spread: Giants +7.5 (-115) | Patriots -7.5 (-105)
• Over/Under: Over 48 (-110) | Under 48 (-110)

↔️ Giants vs. Patriots line movement

The line has stayed planted at Patriots -7.5 (-105) across our best sportsbooks since it opened. Jaxson Dart’s status could certainly have an impact on the final spread, so if we get favorable updates on his progression through concussion protocol, this line could move back toward the Giants throughout the week.

📈 Giants vs. Patriots trends & betting notes: MNF

• Patriots are 2-3-1 ATS in home games
• Giants are 4-1 ATS as an underdog by 7.5 or more points
• Patriots are 0-1-1 ATS as a favorite by 7.5 or more points
• Giants have scored 23.55 PPG since benching Russell Wilson after Week 3

📺 How to watch Giants vs. Patriots: Monday Night Football

• Date: Monday, Dec. 1
• Kickoff: 8:15 p.m. ET
• Location: Gillette Stadium (Foxborough, Mass.)
• TV: ESPN

🔮 More NFL expert early predictions

• Early Packers vs. Lions prediction (Thanksgiving)
• Early Chiefs vs. Cowboys prediction (Thanksgiving)
• Early Bengals vs. Ravens prediction (Thanksgiving)
• Early Bears vs. Eagles prediction (Black Friday)
• Early Broncos vs. Commanders prediction (SNF)
• Early Giants vs. Patriots prediction (MNF)