NFL First Touchdown Scorer Predictions for Week 16: Best Bets to Score 1st TD
Last Updated: December 21, 2025 6:00 AM EST • 2 minute read X Social Google News Link
My NFL first touchdown scorer predictions for Week 16 are pegging the opening scorer for every remaining game on the slate, with tasty odds throughout our NFL Week 16 predictions.
Let's dive in while focusing on the 12 tilts on Sunday and Monday Night Football, with the oft-targeted Amon-Ra St. Brown as the focus.
🏈 NFL first touchdown scorer picks for every game
See all of our experts' NFL picks for Week 16 based on the latest NFL odds.
| Game | 1st TD pick | Best odds | Confidence |
|---|---|---|---|
| Bills vs. Browns | Quinshon Judkins, RB | +625 via Caesars | ⭐⭐⭐⭐ |
| Chargers vs. Cowboys | Quentin Johnston, WR | +1800 via bet365 | ⭐⭐⭐ |
| Chiefs vs. Titans | Xavier Worthy, WR | +1400 via bet365 | ⭐⭐⭐ |
| Bengals vs. Dolphins | Chase Brown, RB | +625 via Caesars | ⭐⭐⭐⭐ |
| Jets vs. Saints | Adonai Mitchell, WR | +1500 via Caesars | ⭐⭐⭐ |
| Vikings vs. Giants | Jordan Addison, WR | +1100 via DraftKings | ⭐⭐⭐ |
| Buccaneers vs. Panthers | Tetairoa McMillan, WR | +1000 via DraftKings | ⭐⭐⭐⭐ |
| Jaguars vs. Broncos | Troy Franklin, WR | +1200 via Caesars | ⭐⭐⭐⭐ |
| Falcons vs. Cardinals | Emari Demercado, RB | +1800 via bet365 | ⭐⭐⭐ |
| Steelers vs. Lions | Amon-Ra St. Brown, WR | +650 via DraftKings | ⭐⭐⭐⭐ |
| Raiders vs. Texans | Jayden Higgins, WR | +1400 via bet365 | ⭐⭐⭐ |
| Patriots vs. Ravens | Stefon Diggs, WR | +1300 via Caesars | ⭐⭐⭐⭐ |
| 49ers vs. Colts | Jauan Jennings, WR | +1000 via Caesars | ⭐⭐⭐⭐ |
💰 Best NFL Week 16 first touchdown scorer prediction
Search the best NFL player prop odds for any team or player across every market from legal sportsbooks in your area.
Amon-Ra St. Brown, WR, Lions (+650) ⭐⭐⭐⭐
The Lions are in full desperation mode. Their status as the -7 favorites against the Pittsburgh Steelers in the NFL odds for Week 16 alongside the game total of 52 indicates there should be plenty of scoring from Detroit, and no doubt early on, too.
Amon-Ra St. Brown will be featured heavily in any high-scoring affair, and especially against a pass funnel Steelers secondary. Pittsburgh ranks 27th against the pass (242.4 yards per game), and St. Brown is tied for second in red-zone targets with 26, where he's posted a sky-high 69.3% catch rate.
💡 More Week 16 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game in Week 16.
🚀 Best first touchdown scorer parlay for NFL Week 16
See all of our NFL touchdown props for Week 16.
🔥 Best NFL 1st TD scorer parlay
- Amon-Ra St. Brown, WR, Lions: To score first TD vs. Steelers (+650) ⭐⭐⭐⭐
- Adonai Mitchell, WR, Jets: To score first TD vs. Saints (+1400) ⭐⭐⭐⭐
- Xavier Worthy, WR, Chiefs: To score first TD vs. Titans (+1200) ⭐⭐⭐
- Jordan Addison, WR, Vikings: To score first TD vs. Giants (+1100) ⭐⭐⭐⭐
- Stefon Diggs, WR, Patriots: To score first TD vs. Ravens (+1300) ⭐⭐⭐⭐
Best odds: +24569900 via DraftKings ($1 to win $245,700, which is the max wager for this parlay at DraftKings)
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Sean Tomlinson X social