Eagles vs. Giants Prediction: Thursday Night Football Opening Odds & Early TNF Picks

Last Updated: October 6, 2025 6:38 AM EDT • 2 minute read X Social Google News Link

It's a battle of the NFC East foes on Thursday Night Football, as I offer an Eagles vs. Giants prediction that expects a defensive struggle. Philadelphia is the 7-point betting favorite despite playing on the road at MetLife Stadium in East Rutherford, N.J.
My NFL picks analyze the chances of both teams combining for 42 or fewer points. The Eagles' defense conceded three points after three quarters to the Denver Broncos before tiring last week, while the New York Giants' stop unit has only conceded more than 26 points once.
Thursday's game starts at 8:15 p.m. ET (Prime Video), and this insight is part of the NFL predictions for Week 6.
🏈 Early Eagles vs. Giants prediction & best bet
Stay ahead with the rest of our early NFL predictions for Week 6.
⬇️ Under 42.5 (-110) ⭐⭐⭐
It took a game for Giants QB Jaxson Dart to realize how challenging it is to be a starting quarterback in the NFL. The rookie signal caller threw two picks at the New Orleans Saints, and his team turned the ball over five times en route to a 26-14 loss to the previously winless squad.
I doubt the G-Men will commit five turnovers two games running, but a short week with a green QB under center after such a demoralizing defeat doesn't bode well, especially against a defending Super Bowl champs team looking to get back in the win column.
The Giants score the fifth-fewest points per game (17.4) and failed to eclipse 10 points twice. They have the third-worst offensive DVOA and are up against an Eagles defense that will be particularly sour after blowing a 14-point lead.
Meanwhile, the Eagles' offense, led by Kevin Patullo, isn't scaring anyone.
It is ranked between 15th and 19th in EPA per play, DVOA, and overall rating, and it's up against a Giants defense that has only allowed more than 26 points once, which came against the high-octane Dallas Cowboys.
It conceded 26 in New Orleans despite committing five turnovers.
Of the best sports betting sites, only FanDuel offers a different total (41.5). BetMGM, Caesars, and DraftKings offer the standard -110 juice for the Under on 42.5 points. A winning $10 bet at those sportsbooks would profit $9.09.
📺️ How to watch Thursday Night Football
Matchup: Eagles vs. Giants
When: Thursday, Oct. 9 @ 8:15 p.m. ET
Where: MetLife Stadium (East Rutherford, N.J.)
TV: Prime Video
📊 Eagles vs. Giants odds: Thursday Night Football
Latest NFL odds updated live in real time.
📈 Eagles vs. Giants opening odds
- Moneyline: Eagles -300 | Giants +240
- Spread: Eagles -6.5 (-115) | Giants +6.5 (-105)
- Over/Under: Over 43.5 (-110) | Under 43.5 (-110)
💡 Eagles vs. Giants odds analysis
The total opened at 43.5 but has since dropped to 42.5. FanDuel has the total at 41.5, the only one offering an outlier low number. However, it's juiced at -118 to the Under. 60% of the bets back the Over, but many of those were probably made when the total was at 43.5. I wouldn't play this Under below 41.5 points.
📃 Affiliate disclosure
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
Not intended for use in MA. Bonuses not applicable in Ontario.
(21+. Gambling Problem? Call 1-800-GAMBLER)

Gary Pearson X social