Eagles vs. Chargers AI Picks: MNF Predictions & Best Prop Bet for Monday Night Football Tonight

The Los Angeles Chargers (8-4) host the Philadelphia Eagles (8-4) tonight on Monday Night Football (8:15 p.m. ET, ESPN), and our Eagles vs. Chargers AI predictions expect the home underdogs to upset the defending champions tonight at SoFi Stadium in Inglewood, Calif.

We've trained the latest ChatGPT model to offer its exact score prediction and projected stat leaders for both teams, as well as its best MNF prop bet tonight. You can catch the rest of our (human) expert picks with our NFL Week 14 predictions.

Eagles vs. Chargers AI predictions: Monday Night Football

See all of our NFL AI predictions for Week 14 with projected scores for every game.

Chargers projected stats

• Passing leader: Justin Herbert – 24/36, 248 yards, 2 TD, 1 INT
• Rushing leader: Omarion Hampton – 15 carries, 68 yards, 1 TD
• Receiving leader: Quentin Johnston – 6 receptions, 77 yards, 1 TD

Eagles projected stats

• Passing leader: Jalen Hurts – 22/34, 235 yards, 1 TD, 1 INT
• Rushing leader: Saquon Barkley – 18 carries, 72 yards, 1 TD
• Receiving leader: A.J. Brown – 7 receptions, 82 yards, 1 TD

Eagles vs. Chargers prediction

The model leans toward a tight, lower-tempo game built around trench play and early-down efficiency. Philadelphia’s offense has sputtered over the last month, particularly on the ground, and heads into SoFi without Lane Johnson against a Chargers front that’s quietly turned into one of the league’s better pass defenses by yards allowed and pressure rate.

On the other side, the Chargers are built to lean into a shotgun-heavy plan that protects Justin Herbert’s surgically repaired non-throwing hand while attacking an Eagles defense that just got gashed on the ground by Chicago and is missing key front-seven pieces. A returning Omarion Hampton working in tandem with Kimani Vidal gives Los Angeles enough rushing efficiency to stay on schedule and keep Herbert out of obvious passing downs, where his receivers can work against an Eagles secondary that’s been strong overall but vulnerable when drives are extended.

Score prediction: Chargers 24, Eagles 23

Best player prop bet for Monday Night Football

See all of our experts' NFL picks based on the latest NFL odds.

Omarion Hampton Over 37.5 rushing yards

This matchup sets up cleanly for Hampton to clear his rushing number given the Chargers’ expected approach with Herbert limited physically. Los Angeles is likely to prioritize early-down efficiency and ball control, leaning on Hampton to keep the Eagles out of obvious pass-rush situations. Philadelphia’s run defense has been uneven over the past few weeks, particularly against downhill and inside-zone concepts, and Hampton’s workload projects to be steady rather than script-dependent in a game expected to stay within one score throughout.

The projected 24–23 Chargers win reinforces a game flow where Los Angeles remains committed to the run well into the fourth quarter rather than abandoning it. If Hampton pushes into the 14–18 carry range, his efficiency against an Eagles front missing key pieces (including Jalen Carter) gives him a strong path to clear this number. With Herbert expected to rely more on rhythm throws than off-script playmaking, Hampton’s rushing volume becomes a foundational piece of the Chargers’ offensive plan and the most reliable prop angle in this matchup.

Best bet: Omarion Hampton Over 37.5 rushing yards (-115 via BetMGM)

How to watch Monday Night Football: Eagles vs. Chargers

• Date: Monday, Dec. 8
• Kickoff: 8:15 p.m. ET
• Location: SoFi Stadium (Inglewood, Calif.)
• TV: ESPN

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