Cowboys vs. Eagles Prediction, Odds & Expert Picks: NFL Season Opener Best Bets
The reigning Super Bowl champion Philadelphia Eagles get the 2025 season underway on Thursday when they host the Dallas Cowboys, and my Cowboys vs. Eagles prediction sheds more light on the numerous issues the visitors face in the NFL's season opener.
For these NFL picks, I added two player props, including an appealing bonus pick that features the Cowboys' primary offensive threat. Kickoff from Lincoln Financial Field is set for 8:20 p.m. ET (NBC), and the Eagles are the 8 or 8.5-point betting favorite as we make our NFL predictions for Week 1.
🏈 Cowboys vs. Eagles expert picks & predictions
NFL expert picks made Wednesday; odds subject to change. Pick confidence based on a 1-to-5-star rating.
- Moneyline pick: Eagles (-395 via DraftKings) ⭐
- Against the spread pick: Eagles -8 (-110 via bet365) ⭐⭐⭐⭐
- Over/Under pick: Over 47.5 (-110 via FanDuel) ⭐⭐⭐
📝 Cowboys vs. Eagles preview & best bet
Track the latest NFL scores for line movement and matchup info.
🦅 Eagles -8 ⭐⭐⭐⭐
This matchup, for the Dallas Cowboys, reminds me of a blind date featuring an impoverished, overweight middle-aged man and a 20s-something model. I expect things to go as well for the Cowboys as they would for the former in that hypothetical example.
The Cowboys were 2-6 ATS last season when Dak Prescott lined up under center. They didn't do much to improve an offensive line that ranked 23rd last season, via PFF.
While the Eagles had a couple of influential members of their defense depart, they should still have an elite defensive line, which PFF ranked as the second-best pressure unit last season.
Yes, wide receiver George Pickens will help Dallas' offense, but by how much? Considering their lackluster running back room, not nearly enough.
Things are even worse defensively. With Micah Parsons' unceremonious exit, the Cowboys will lose at least 23% of their sack share, and that's being generous. He had 12 of Dallas' 52 sacks last season in just 13 games, and how many did he create by drawing double teams?
The Cowboys had the second-worst run defense last season, via PFF, while the Eagles have arguably the most impactful one-two punch. And then there's the Cowboys' secondary, which will be without rookie cornerback Shavon Revel Jr. Trevon Diggs, who wasn't expected to feature until Week 4, said there's a 75-80% chance he'll play.
The Eagles won't lose any sleep if he does suit up, as there is no way he will be game fit after being out for so long. It's why I'm backing Philadelphia with my NFL picks against the spread.
The spread increased to -8.5 at three of the best sports betting sites and -8 at bet365 and Caesars. Both of the latter offer standard -110 juice, which I'm pleased as punch about.
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💰 Best Cowboys vs. Eagles player prop bets
Our NFL player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Dallas Goedert Over 36.5 receiving yards (-110) ⭐⭐⭐⭐
Eagles tight end Dallas Goedert got healthy at the right time last year, and he was a monster in the playoffs, amassing at least 47 receiving yards in all three games prior to the Super Bowl. He averaged 53.75 receiving yards per game in the postseason, and cashed the Over on this total in four of his final five games before lifting the Lombardi Trophy.
BetMGM offers the lowest total while offering the standard -110 juice. While DraftKings offers plus-money odds (+101), I'm not as confident in its elevated 39.5-yard total. Caesars has a higher total than BeMGM (38.5) and offers worse value (-115).
A winning $10 bet at BetMGM will yield a $9.09 profit.
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⬆️ CeeDee Lamb Over 71.5 receiving yards (-114) ⭐⭐⭐⭐
Pickens should make it slightly more challenging for defenses to double up on CeeDee Lamb, who should be in for a highly productive season.
With the Cowboys expected to air it out more often and the question marks in the Eagles secondary, I like Lamb to cash this Over. In addition, the game script should be conducive for Lamb to amass a bunch of yards when the Cowboys are chasing in the latter stages. A winning $10 bet at FanDuel would yield an $8.77 profit.
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📊 Cowboys vs. Eagles odds: Week 1
NFL odds update live in real time.
📈 Cowboys vs. Eagles opening odds
- Moneyline: Cowboys +260 | Eagles -325
- Spread: Cowboys +6.5 (-108) | Eagles -6.5 (-120)
- Over/Under: O46.5 (-110) | U46.5 (-110)
🔍 Cowboys vs. Eagles odds analysis
The Eagles opened as the 6.5-point betting favorite on the NFL Week 1 odds. Money has poured in on the Eagles, with the Cowboys vs. Eagles spread increasing to between 8 and 8.5 points. About 60% of bets are on the Eagles to cover, while 64% of bets are backing the Over (47.5 points).
Liam Fox's NFL weather report for Week 1 assesses the game-time conditions at Lincoln Financial Field and how those may impact the odds for the season opener.
🔢 Cowboys vs. Eagles stats
Last season's stats courtesy of Pro Football Reference.
| Cowboys (7-10) | Statistic (per game) | Eagles (14-3) |
|---|---|---|
| 20.6 | Points | 29 |
| 27.5 | Points allowed | 18.1 |
| -0.4 | Turnover margin | 1.1 |
| 227.2 | Passing yards | 181.9 |
| 100.3 | Rushing yards | 184.1 |
| 218.1 | Passing yards allowed | 186.9 |
| 137.1 | Rushing yards allowed | 101.8 |
| -0.8 | Net yards per play | 0.6 |
🚑 Cowboys vs. Eagles injury report
📺 How to watch Cowboys vs. Eagles & game info
- Channel: NBC
- When: Thursday, Sept. 4
- Kickoff: 8:20 p.m. ET
- Where: Lincoln Financial Field (Philadelphia)
💡 NFL predictions for Week 1
- Cowboys vs. Eagles prediction
- Early Ravens vs. Bills prediction
- Early Vikings vs. Bears prediction
❓ Cowboys vs. Eagles FAQs
Who is favored to win Cowboys vs. Eagles?
The Eagles are the massive favorite, with moneyline odds of between -395 and -450.
What is the spread for Cowboys vs. Eagles?
The Eagles are the 8 or 8.5-point betting favorite.
What is the Over/Under for Cowboys vs. Eagles?
The total is set at 47.5 points, with -110 odds for both the Over and Under.
What are the best bets for Cowboys vs. Eagles?
The Eagles to cover, Dallas Goedert to amass at least 37 receiving yards and CeeDee Lamb to go Over 71.5 yards are my best bets.
When is the Cowboys vs. Eagles game?
Thursday's game from Lincoln Financial Field starts at 8:20 p.m. ET (NBC).
How do NFL odds work?
When betting on NFL odds, the point spread shows how many points the favorite needs to win by in order to cash the bet. For example, a favorite of -3 must win by more than 3 points to cover the spread, while an underdog at +3 must win outright or lose by fewer than 3 points to cover the spread.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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