Cowboys vs. Eagles Expert Picks Tonight - NFL Week 1

Eagles -8.5 favorite, Hurts anytime TD (-145), Pickens TD (+220), Prescott Over 244.5 yds - expert picks for Cowboys vs. Eagles tonight.

Esten McLaren

Last Updated: September 4, 2025 5:41 PM EDT • 3 minute read

Cowboys vs. Eagles Expert Picks Tonight - NFL Week 1 — Pictured: Dallas Cowboys quarterback Dak Prescott (4) warms up before the game. Photo by Jerome Miron-Imagn Images.

Tune into the NFL's 2025 season opener between the Dallas Cowboys and Philadelphia Eagles at Lincoln Financial Field in Philadelphia tonight at 8:20 p.m. ET on NBC. The host Eagles are 8.5-point betting favorites by the latest NFL odds as you finalize your NFL picks.

Here are the best of our NFL predictions for Cowboys vs. Eagles tonight:

Cowboys vs. Eagles expert picks (tonight’s game)

Strong lean toward Eagles covering -8.5 points, with key prop targets: Hurts anytime TD, Pickens anytime TD, and Prescott Over 244.5 passing yards.

Cowboys vs. Eagles spread prediction & best bets

From Brenden Schaeffer's Cowboys vs. Eagles parlay picks:

Eagles -8.5 (-105, FanDuel): Four-star confidence
Dak Prescott Over 244.5 passing yards (-113)
Saquon Barkley Over 95.5 rushing yards (-113) in the same parlay (+570 odds)

Cowboys vs. Eagles player props & TD scorers

Pick confidence is based on a 1-to-5-star rating.

From Matt Jacob's best Cowboys vs. Eagles player prop bets:

Jalen Hurts anytime touchdown (-145, DraftKings): High confidence (⭐⭐⭐⭐)
Saquon Barkley Under 96.5 Rushing Yards (-105): Moderate confidence (⭐⭐⭐)
Dak Prescott Over 247.5 Passing Yards (-115): Moderate confidence (⭐⭐⭐)

From Isaiah Sirois' Cowboys vs. Eagles anytime touchdown scorer predictions:

George Pickens anytime TD (+220): Moderate confidence (⭐⭐⭐)
Saquon Barkley anytime TD (-195): Low confidence (⭐)
A.J. Brown anytime TD (+160): Higher confidence (⭐⭐⭐⭐)

From Sean Tomlinson's first touchdown scorer predictions:

Jalen Hurts to score first (+475): High confidence (⭐⭐⭐⭐)
CeeDee Lamb to score first (+1200): Moderate confidence (⭐⭐⭐)

Cowboys vs. Eagles live odds

Cowboys vs. Eagles best bets summary table

Category	Best pick(s)	Confidence
Spread	Eagles -8.5	⭐⭐⭐⭐
Parlay	Eagles -8.5 + Prescott/Yds + Barkley/Yds	—
Hurts Anytime TD	Hurts to score anytime	⭐⭐⭐⭐
First TD Scorer	Hurts (+475) / Lamb (+1200)	⭐⭐⭐⭐ / ⭐⭐⭐
Anytime TD	Pickens (+220) / Brown (+160) / Barkley (-185)	⭐⭐⭐ / ⭐⭐⭐⭐ / ⭐
Prescott Over 244–247 yds	Prescott Over	⭐⭐⭐⭐
Barkley Under 96.5 yds	Barkley Under	⭐⭐⭐

Related Cowboys vs. Eagles betting tools

Cowboys vs. Eagles expert picks

How to watch Cowboys vs. Eagles

When: Thursday, Sept. 4
Kickoff: 8:20 p.m. ET
Where: Lincoln Financial Field (Philadelphia)
Channel: NBC

Cowboys vs. Eagles FAQs

Which team is favored on the spread? Eagles -8.5 with high confidence
Top Cowboys vs. Eagles prop bet? Hurts Anytime TD (-145) and Prescott Over 244.5 yards
Any touchdown parlay? George Pickens, Saquon Barkley, and A.J. Brown are key anytime TD targets

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Written by:
Esten McLaren

Esten is the Content Manager for SportsbookReview.com. He has been in the sports betting industry since the legalization of mobile sports betting in New Jersey, and with SportsbookReview prior to the launch of sports betting in Ontario. Esten's previous stops include the USA TODAY network, including GolfWeek. He previously worked in the fantasy sports industry, with FNTSY Sports Network, theScore, and USA TODAY, where he started to build his NFL experience in the iGaming industry. Esten graduated from the College of Sports Media with a diploma in Radio and Television Sports Broadcasting after acquiring a degree in Biological Sciences from the University of Guelph. He has appeared on FNTSY Sports Network, VSiN, and VSiN's Long Shots podcast, where he correctly called Will Zalatoris as the winner of the 2022 FedEx St. Jude Championship. Esten is a big proponent of the entertainment side of sports betting and loves to dip his toes into the novelty and alt-markets while chasing long shots with reduced wagers on golf outrights and futures markets. He's also been known to sprinkle some lunch money on touchdown-scorer parlays with two notable hits funding his bankroll. Esten looks at sports betting much like golf and advises beginner bettors to compete against themselves rather than being concerned with what others may or may not be doing based on social media claims.