Chiefs vs. Jaguars Prediction: Early Monday Night Football Odds & MNF Picks
Last Updated: October 2, 2025 7:15 PM EDT • 2 minute read X Social Google News Link
I'm breaking down this week's Monday Night Football matchup with my early Chiefs vs. Jaguars prediction as part of our NFL predictions for Week 5.
Kansas City is a 3-point road betting favorite ahead of Monday's 8:15 p.m. ET (ABC/ESPN) kickoff at EverBank Stadium in Jacksonville, Fla.
I target the Under with my NFL picks in a game featuring two of the league's top-10 scoring defenses.
🏈 Early Chiefs vs. Jaguars prediction & best bet
Stay ahead with the rest of our early NFL predictions for Week 5.
⬇️ Under 45.5 (-110) ⭐⭐⭐⭐
After defeating the Baltimore Ravens 37-20 in Week 4, the Chiefs have now held three consecutive opponents to 20 or fewer points, allowing just 19.0 points per game. While the offense finally clicked, scoring a season-high 37 against Baltimore, that speaks more to how bad the Ravens’ defense is rather than how good the Chiefs’ offense is.
Meanwhile, the Jaguars have held three of their four opponents to 21 or fewer. And while the offense is averaging 24.0 points per game, the third-ranked rushing attack will have a hard time against a run defense that just held Derrick Henry and Lamar Jackson to 42 and 48 yards, respectively.
The best sports betting sites are offering Under 45.5 for -110. The price of -110 suggests a 52.38% chance the Under hits. A winning $10 bet would profit $9.09.
📊 Chiefs vs. Jaguars odds: Monday Night Football
Latest NFL odds updated live in real time.
📈 Chiefs vs. Jaguars opening odds
- Moneyline: Chiefs -165 | Jaguars +140
- Spread: Chiefs -3 (-110) | Jaguars +3 (-110)
- Over/Under: Over 45.5 (-110) | Under 45.5 (-110)
💡 Chiefs vs. Jaguars odds analysis
The Under 45.5 is my best play of this game, but I think you can wait to get in. The total opened at 44.5, and it has already risen to 45.5. With 59% of wagers backing the Over, this total could climb as high as 47 before the week ends.
The Chiefs opened as 3-point favorites, and after their dominant win over the Ravens, nearly three-quarters of bets are backing them to cover in this game. This spread will hit 3.5 or 4 at some point this week, so if you’re on the Jaguars, wait to wager.
How to watch Monday Night Football
- Matchup: Chiefs vs. Jaguars
- When: Monday, Oct. 6
- Time: 8:15 p.m. ET
- Where: EverBank Stadium (Jacksonville, Fla.)
- TV: ABC/ESPN
💡 NFL Week 5 predictions
- 49ers vs. Rams prediction
- Vikings vs. Browns prediction
- Patriots vs. Bills prediction
- Chiefs vs. Jaguars prediction
📃 Affiliate disclosure
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
Not intended for use in MA. Bonuses not applicable in Ontario.
(21+. Gambling Problem? Call 1-800-GAMBLER)
Philip Wood X social