Chiefs vs. Cowboys Same-Game Parlay for Thanksgiving: Today's SGP Odds & Best Picks

My Chiefs vs. Cowboys same-game parlay for Thanksgiving looks for Patrick Mahomes’ first appearance of the season in a dome environment to be a productive one, inspiring a highly anticipated shootout for your holiday viewing pleasure.

The action for Chiefs vs. Cowboys kicks off from AT&T Stadium in Arlington, Texas, Thursday at 4:30 p.m. ET (CBS). The Chiefs are 3.5-point betting favorites as part of our NFL Thanksgiving predictions.

✅ Chiefs vs. Cowboys same-game parlay for Thanksgiving

See all of our experts' NFL picks based on the latest NFL odds.

💰 Best Thanksgiving parlay picks & SGP bets

🚀 Over 52.5 (-110) ⭐⭐⭐⭐

The highest game total of the Thanksgiving slate should hit the Over when Patrick Mahomes and Dak Prescott get together in a dome environment. Mahomes hasn’t gotten to play an indoor game all year, while the Cowboys have seen three out of five home games go Over.

These two offenses have combined to average 54.7 PPG this season. Dallas home games average 58.8 total points per game and have experienced an average margin of +12.9 PPG against the total (2nd-highest in NFL).

Our C Jackson Cowart broke down the matchup from a different angle with Chiefs vs. Cowboys AI predictions.

🚀 Xavier Worthy anytime TD scorer (+200) ⭐⭐⭐⭐

Xavier Worthy has endured multiple injuries this season, ultimately producing lesser numbers as a result. But the second-year wideout looked good last week against the Colts, hauling in a 31-yard reception as part of a 4-catch, 59-yard day.

The Cowboys are the most generous defense in the league for wide receivers looking to score touchdowns, as Dallas has permitted 18 scores to opposing wideouts. Worthy’s odds at +200 are strong considering this trend and our expectation that the game goes Over the lofty total.

Our NFL expert Matt Jacob breaks this game down further in his Chiefs vs. Cowboys prediction.

🚀 CeeDee Lamb Over 6.5 receptions (-102) ⭐⭐⭐⭐

Ceedee Lamb has logged at least seven receptions in four of his seven full games played this season. It’s been quieter over the past couple of outings, but we’re looking for Lamb to overcome his bizarre issues with drops to become a focal point of a Dallas offense that will need to throw with regularity to keep up with Kansas City.

Excluding the game in which he was injured on a handoff before being targeted, Lamb is averaging 10.28 targets per game this year. Dallas has allowed a completion on 69.3% of WR targets.

💡 Chiefs vs. Cowboys picks

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• Chiefs vs. Cowboys same-game parlay
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• Chiefs vs. Cowboys AI predictions
• Chiefs vs. Cowboys best bets

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📺 How to watch Chiefs vs. Cowboys: Thanksgiving 2025

• Date: Thursday, Nov. 27
• Kickoff: 4:30 p.m. ET
• Location: AT&T Stadium (Arlington, Texas)
• TV: CBS