Buffalo Bills 2025 Schedule, Odds & Predictions: AI Picks for Every Game

We're breaking down everything you need to know about the Bills, including odds and projections for all 17 games.

Last updated: May 15, 2025 12:37 PM EDT • 4 min read

Buffalo Bills 2025 Schedule: Game-by-Game Odds, Predictions & AI Picks — Pictured: Buffalo Bills quarterback Josh Allen (17) scrambles from Baltimore Ravens safety Eddie Jackson (39). Photo by Geoff Burke / Imagn Images.

We're breaking down the Buffalo Bills schedule, odds, and predictions for the 2025 NFL season following the official schedule release. The Bills are projected to win 11.5 games across our best sports betting sites, and we're offering our 2025 win-loss predictions with AI picks for all 17 games.

📅 Buffalo Bills 2025 schedule & odds for every game

Odds via DraftKings as of Thursday, May 15. All times listed in Eastern Time.

Week	Date	Opponent	Favorite
1	Sunday, Sept. 7 @ 8:20 PM	vs. Ravens	Bills -1.5
2	Sunday, Sept. 14 @ 1 PM	at Jets	Bills -8.5
3	Thursday, Sept. 18 @ 8:15 PM	vs. Dolphins	Bills -8.5
4	Sunday, Sept. 28 @ 1 PM	vs. Saints	Bills -12.5
5	Sunday, Oct. 5 @ 8:20 PM	vs. Patriots	Bills -8.5
6	Monday, Oct. 13 @ 7:15 PM	at Falcons	Bills -5.5
7	BYE WEEK	-	-
8	Sunday, Oct. 26 @ 1 PM	at Panthers	Bills -7
9	Sunday, Nov. 2 @ 4:25 PM	vs. Chiefs	Bills -2.5
10	Sunday, Nov. 9 @ 1 PM	at Dolphins	Bills -5.5
11	Sunday, Nov. 16 @ 1 PM	vs. Buccaneers	Bills -5.5
12	Thursday, Nov. 20 @ 8:15 PM	at Texans	Bills -3.5
13	Sunday, Nov. 30 @ 4:25 PM	at Steelers	Bills -4.5
14	Sunday, Dec. 7 @ 4:25 PM	vs. Bengals	Bills -5.5
15	Sunday, Dec. 14 @ 1 PM	at Patriots	Bills -4.5
16	Sunday, Dec. 21 @ 1 PM	at Browns	Bills -8.5
17	Sunday, Dec. 28 @ 4:05 PM	vs. Eagles	Bills -1.5
18	TBD	vs. Jets	Bills -9.5

👉 Check out the full 2025 NFL schedule with odds for every game.

📊 Buffalo Bills odds to win Super Bowl & best futures bets

🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area!

💰 Buffalo Bills O/U win total

Latest NFL win totals via BetMGM as of Thursday, May 16.

Over 11.5 wins: -160 (bet $10 to win $6.25)
Under 11.5 wins: +135 (bet $10 to win $13.50)

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🔮 Buffalo Bills 2025 predictions: Game-by-game picks & final record

Check out our 2025 NFL season predictions for projected standings, playoff results, and award winners - and a breakdown of how our AI model predicts every game.

🤖 Buffalo Bills 2025 AI projections

Week 1: Bills 30, Ravens 26 ✅
Week 2: Bills 24, Jets 14 ✅
Week 3: Bills 24, Dolphins 20 ✅
Week 4: Bills 34, Saints 16 ✅
Week 5: Bills 27, Patriots 13 ✅
Week 6: Bills 27, Falcons 24 ✅
Week 8: Bills 31, Panthers 13 ✅
Week 9: Chiefs 31, Bills 28 ❌
Week 10: Dolphins 27, Bills 21 ❌
Week 11: Bills 21, Buccaneers 20 ✅
Week 12: Bills 33, Texans 29 ✅
Week 13: Steelers 19, Bills 16 ❌
Week 14: Bills 27, Bengals 24 ✅
Week 15: Bills 20, Patriots 16 ✅
Week 16: Browns 26, Bills 23 ❌
Week 17: Bills 34, Eagles 30 ✅
Week 18: Jets 23, Bills 17 ❌

🏈 Buffalo Bills 2025 record prediction

Projected win-loss record: 12-5

🦬 Buffalo Bills Week 1 odds vs. Ravens

The Bills welcome the Baltimore Ravens to Highmark Stadium on Sunday, Sept. 7. Kickoff is set for 8:20 p.m. ET. Buffalo opened as a 1.5-point favorite.

🔮 2025 NFL season previews & predictions

Following the NFL schedule release, we broke down the odds for every game and asked AI to predict every game (and more). Below are our team-by-team schedules, odds, and predictions for Week 1 through Week 18.

Buffalo Bills	Miami Dolphins	New York Jets	New England Patriots
Baltimore Ravens	Pittsburgh Steelers	Cincinnati Bengals	Cleveland Browns
Houston Texans	Indianapolis Colts	Jacksonville Jaguars	Tennessee Titans
Kansas City Chiefs	Los Angeles Chargers	Denver Broncos	Las Vegas Raiders
Philadelphia Eagles	Washington Commanders	Dallas Cowboys	New York Giants
Detroit Lions	Minnesota Vikings	Green Bay Packers	Chicago Bears
Tampa Bay Buccaneers	Atlanta Falcons	Carolina Panthers	New Orleans Saints
Los Angeles Rams	Seattle Seahawks	Arizona Cardinals	San Francisco 49ers

💵 Best NFL betting sites

Ready to bet on the NFL this season? Check out our best NFL betting sites and the best sportsbook promos for the 2025-26 NFL season:

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.