Buccaneers vs. Lions Prediction, Picks & Odds: Monday Night Football Week 7

Last Updated: October 19, 2025 7:37 AM EDT • 2 minute read X Social Google News Link

The Detroit Lions and Tampa Bay Buccaneers, two of the league's most explosive offenses, feature on Monday Night Football, and my Buccaneers vs. Lions prediction and NFL picks expect both teams to combine to cash the Over 52.5 points.
The Lions are the 5.5 or 6-point betting favorite for the clash at Ford Field in Detroit, which starts at 8:20 p.m. ET (ESPN). The analysis below is part of the NFL predictions for Week 7.
🏈 Buccaneers vs. Lions prediction: Monday Night Football
NFL expert picks for Monday Night Football; NFL odds subject to change.
- Spread prediction: Lions -5.5 (-120 via FanDuel) ⭐⭐⭐
- Over/Under pick: Over 52.5 (-110 via BetMGM) ⭐⭐⭐⭐
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🆚 Who will win Buccaneers vs. Lions?
The Lions defeated the Chicago Bears 52-21 at home in the game after their previous defeat on the road. While I'm in no way comparing the Bears to the Buccaneers, Detroit saves some of its best stuff for bounce-back opportunities. The Lions have won 11 straight after suffering a defeat dating back to 2022. I'm also counting on the Lions at home to make the most of the Buccaneers' injuries.
Buccaneers vs. Lions score prediction: Buccaneers 27-Lions 34
✅ Buccaneers vs. Lions best bet for MNF
Track the latest NFL scores for line movement and matchup info.
⬆️ Over 52.5 (-110) ⭐⭐⭐⭐
Dan Campbell's team have scored at least 31 points in eight of the last nine games at Ford Field dating back to last season, averaging 40. That staggering total is accompanied by a 32-point-per-game average in the previous 11 games following a defeat.
Both teams are among the top eight in offensive DVOA, with Detroit fifth and Tampa Bay eighth, while the Lions score the second-most points per game (31.8) and the Buccaneers the sixth most (27.5).
In addition, the Lions will be without starting cornerback Terrion Arnold and starting safety Kerby Joseph, which should make life tangibly more straightforward for Baker Mayfield, who won't have running back Bucky Irving or wide receiver Mike Evans at his disposal. If we know anything through six weeks, it's that Mayfield, the league's most clutch QB entering Week 7, will score points no matter who is in or out of the lineup.
The Buccaneers' defense allows the ninth-most points per game (25.2), and the Lions concede 23.7, ranked 18th.
The best sports betting sites have reached a consensus, offering a total of 52.5. The odds range from -110 to -115, with FanDuel and BetMGM offering the former. A winning $10 bet at the -110 odds, the best value on offer, will yield $9.09.
📊 Buccaneers vs. Lions odds: Monday Night Football
Latest Monday Night Football odds updated live in real time.
📺 How to watch Monday Night Football
- Matchup: Buccaneers vs. Lions
- When: Monday, Oct. 20
- Kickoff: 8:20 p.m. ET
- Where: Ford Field (Detroit)
- TV: ESPN
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Gary Pearson X social