Brock Purdy Player Props vs. Colts: Will Purdy Dominate on Monday Night Football?
The 49ers take on the Colts under the lights of Monday Night Football, and Iām breaking down my top Brock Purdy player props to get you ready for the 8:15 p.m. ET kickoff at Lucas Oil Stadium on ESPN as part of our NFL predictions for Week 16.
The 49ers come into this one as 5.5-point favorites with 44-year-old Philip Rivers still quarterbacking the Colts. Will Purdy get the best of him? Let's dive in.
š Brock Purdy player prop bets vs. Colts
See all of our NFL picks for Week 16 based on the latest NFL odds.
| Prop bet | Best odds | Confidence |
|---|---|---|
| Purdy Over 243.5 passing yards | -112 via FanDuel | āāāāā |
| Purdy Over 21.5 pass completions | -119 via DraftKings | āāāā |
| Purdy Over 9.5 rush yards | -110 via BetMGM | āāāā |
š° Best Brock Purdy player prop pick: Play of the Day (2u)
Search the best NFL player prop odds for any team or player across every market from legal sportsbooks in your area.
Purdy Over 243.5 passing yards (-112) āāāāā
The Indianapolis Colts are just getting gashed through the air, coughing up 247 passing yards per game - good for 30th in football. Sam Darnold dropped 271 last week on the Colts' secondary, Trevor Lawrence went for 244 before him, and a struggling C.J. Stroud dropped 276 three weeks ago. I have all the faith in the world in this offense to light this Colts team on fire in what could end up being a blowout when the dust has settled. Fire this one up as part of our best Brock Purdy player props.
🤑 Brock Purdy SGP (+248)
If you're looking for a bigger payout, parlay Purdy's passing yard props with his Over 21.5 pass completions at DraftKings (-119). There's going to be little to no pushback from this Colts defense tonight.
Looking for more plays tonight? Tap into my Jonathan Taylor player props for Monday Night Football.
š Brock Purdy rushing trends
The volume we're seeing out of Purdy this season makes me think his rushing total is worth at least a 1u play. It's not quite my best bet for tonight's Monday Night Football matchup, but he's averaging around five attempts per game this year. Last week, he went for 44 yards against the Tennessee Titans, and I'm expecting this Colts' front-seven to put the pressure on if they have any chance of staying in this game. Look for Purdy to move the pocket and cash this play for us early on. Play this one with confidence as part of my best Brock Purdy player props.
š¢ Brock Purdy game log
| Opponent | Completions | Attempts | Passing Yards | Yards/Attempt | Passing TDs | Rush Yards |
|---|---|---|---|---|---|---|
| ARI | 19 | 26 | 200 | 7.7 | 3 | -7 |
| CAR | 23 | 32 | 193 | 6.0 | 1 | 16 |
| CLE | 16 | 29 | 168 | 5.8 | 1 | 4 |
| TEN | 23 | 30 | 295 | 9.8 | 3 | 44 |
💡 More Week 16 predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for Week 16.
šŗ How to watch Monday Night Football: Colts vs. 49ers
- Date: Monday, Dec. 22, 2025
- Kickoff: 8:15 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- TV: ESPN
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Related Articles
