Best NFL Long Shot Parlay Today: Week 6 Moneyline Picks for Every Game

My best NFL long-shot parlay today for Week 6 focuses on a seven-leg parlay and a moneyline prediction for each game, strung together to facilitate a potential profit of over $4,000 if each leg hits. 

These NFL picks, part of the NFL predictions for Week 6, also feature a five-leg parlay that would return $169.67 on a $10 winning bet.  

💰 My best NFL parlay picks for Week 6

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This five-leg parlay is split between two moneyline plays, an against-the-spread pick, and a pair of player props. While the Tampa Bay Buccaneers will be without Bucky Irving, the San Francisco 49ers are riddled with even more personnel issues. I give the Buccaneers the slight edge, especially with how well Baker Mayfield, the NFL's most clutch QB through five weeks, is playing. 

The New England Patriots represent one of the "safest" moneyline picks at decent odds. They were terrific against Buffalo and have a favorable matchup against a New Orleans Saints team that should emphasize their run attack.

The Los Angeles Chargers' offensive line and backfield have been decimated by injuries, which is why I believe Miami will keep things close at home. 

My player props feature Offensive Rookie of the Year odds favorite Emeka Egbuka, who is facing a San Francisco 49ers team that might be without safety Malik Mustapha (knee) and cornerback Upton Stout (ankle). That's on top of the other defensive injuries they are dealing with. 

Finally, I'm backing Jayden Daniels to rush for at least 44 yards. He gained 39 yards on his return from injury last week. He'll be more confident about his knee in his second week back and should take advantage against the Chicago Bears, who have the fifth-worst defensive rushing DVOA. 

If all five legs hit, you'll earn a $179.67 profit on a $10 bet.

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🎯 My best NFL long-shot parlay for Week 6

I've added two legs to the previous parlay, which would facilitate a $328.79 profit on a $10 bet if all seven legs hit. I'm backing Puka Nacua, who is among the NFL record-breaker player props, to have another productive outing, this time in Baltimore against the injury-plagued Ravens.

He's averaging 117.6 receiving yards per game and has only hit the Under on the 92-yard total once. 

The final addition backs Bijan Robinson when he faces a Buffalo Bills team tied with the Miami Dolphins for allowing the second-most yards per rush attempt (5.6), with the third-worst defensive rushing DVOA.

🚀 My best NFL moneyline parlay picks for every game

I've backed two underdogs in the Week 6 slate, including the Detroit Lions and Miami Dolphins. The Lions are playing at an elite level, and the Kansas City Chiefs have struggled to find consistency throughout. 

Detroit, which I backed in my against-the-spread picks, is 9-2 ATS on the road since the start of last season.

The second addition foresees the Dolphins upsetting the Chargers in Miami. Los Angeles is in big trouble on the offensive side of the ball, dealing with a makeshift offensive line and down both of their primary running backs, Omarion Hampton and Najee Harris. 

If all predictions are correct, a winning $10 bet will profit $4,045.