Anytime Touchdown Scorer Predictions for Monday Night Football: 49ers vs. Colts TD Picks
Monday Night Football between the San Francisco 49ers (10-4) and Indianapolis Colts (8-6) tonight gives us our last chance to load up our bankroll with anytime touchdown scorer predictions ahead of the NFL's three-game slate on Christmas Day. The 49ers are the 5.5-point betting favorite on the road at Lucas Oil Stadium in Indianapolis, with an Over/Under of 46.5 calling for 6-7 touchdowns to be scored during the 8:15 p.m. ET broadcast on ESPN.
Philip Rivers will make his second start for the free-falling Colts, while the 49ers look to gain ground in the NFC West race.
🏈 Anytime touchdown scorer predictions: 49ers vs. Colts
See the latest NFL odds and our experts' NFL picks for every game this season.
| Player | Best odds | Confidence |
|---|---|---|
| Jauan Jennings, WR, 49ers | +145 via Caesars | ⭐⭐⭐⭐⭐ |
| Alec Pierce, WR, Colts | +550 via DraftKings | ⭐⭐⭐ |
| 49ers defense | +800 via FanDuel | ⭐⭐⭐ |
💰 Best Monday Night Football anytime touchdown scorer bet
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Jauan Jennings, WR, 49ers (+145) ⭐⭐⭐⭐⭐
Jauan Jennings has led 49ers receivers in snap share in eight straight games. He's scored six touchdowns across his last six games, including two last week. He also leads the team's receivers with six red-zone touchdowns, eight receptions, and 16 targets inside the 20.
The Colts will again be without cornerback Sauce Gardner tonight. Though he likely would've focused on Ricky Pearsall, that absence shifts around the entire defense and leaves Jennings with even more room to operate.
Brenden Schaeffer has this pick in his 49ers vs. Colts same-game parlay, while Sean Tomlinson is eyeing another Niners pass-catcher in his first touchdown scorer predictions for Monday Night Football.
🙌 More 49ers vs. Colts TD picks
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Alec Pierece, WR, Colts (+550) ⭐⭐⭐
Alec Pierce has two touchdowns on the season but was targeted just once in Rivers' debut under center last week, despite playing every offensive snap. He caught it for a 16-yard gain.
I'm going to trust in the playing time more than the usage. Though Rivers averaged just 3.52 air yards per attempt last week, Pierce is leading the NFL for the second straight season in yards per reception. He'll need to do more work after the catch than usual to compensate for Rivers' lack of arm strength, but the 49ers rank in the middle of the league in YAC allowed.
Phil Wood is taking teammate Michael Pittman Jr. to reach the end zone with his 49ers vs. Colts player props.
49ers defense (+800) ⭐⭐⭐
There's not a whole lot to this anytime touchdown scorer prediction other than Old Man Rivers completed just 66.7% of his passes for only 120 yards last week. He threw an interception and fumbled.
Though the San Francisco defense isn't as formidable as we've been accustomed to in recent years, ranking near or at the bottom of the league in interceptions (5), sacks (16), pressure percentage (15.5%), and blitz percentage (17.9%), they need only to be opportunistic in this matchup and let Rivers make his own mistakes.
💰️ 49ers vs. Colts prediction
Our Mike Spector backs the Over 46.5 as his best 49ers vs. Colts prediction. A high-scoring game (in which San Francisco is favored by 5.5 points) should force Rivers to the air more often and open him up to mistakes.
🚀 49ers vs. Colts anytime touchdown scorer parlay
See all of our NFL touchdown props for Monday Night Football and more.
💰️ Total odds: +9568 | $10 bet pays $956.87 profit
I'm making my 49ers vs. Colts anytime touchdown scorer SGP at FanDuel, as the sportsbook offers the best odds for the 49ers defense to score. A winning $10 bet would pay a profit of $956.87 ahead of the holiday.
DraftKings offers team defense and special teams (punt or kickoff return) as a combination, while this bet at FanDuel needs a defender to score on a pick-6 or fumble return.
📊 Anytime touchdown scorer odds: 49ers vs. Colts
📺 How to watch Monday Night Football: 49ers vs. Colts
- Date: Monday, Dec. 22
- Kickoff: 8:20 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- TV: ESPN
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