NFL AI Predictions Week 4: ATS Picks & Score Projections for Every Game

Last Updated: September 25, 2025 11:00 AM EDT • 7 minute read X Social Google News Link

Our NFL AI predictions have gone 27-21 against the spread (56.3%) entering NFL Week 4, including 10-5 on our best NFL picks each week according to our AI model.
We trained the latest ChatGPT model to make its weekly NFL predictions and projected scores for every game this week based on real-time search and advanced metrics, while offering a full box score and game preview for its five most confident picks.
If you can beat the bot in our free weekly NFL contest, you'll enter a draw to win SBR swag while competing for more than $5,000 in total prizes.
🤖 NFL AI predictions for Week 4
NFL AI predictions and score projections via ChatGPT simulation model with ATS pick confidence based on a 1-to-5-star scale and latest NFL odds.
Prediction | ATS pick | Confidence |
---|---|---|
Seahawks 23, Cardinals 20 | Seahawks -1 | ⭐⭐⭐⭐⭐ |
Vikings 24, Steelers 21 | Vikings -2 | ⭐⭐⭐ |
Bills 30, Saints 17 | Saints +16 | ⭐⭐⭐ |
Texans 24, Titans 13 | Texans -7 | ⭐⭐⭐⭐⭐ |
Lions 27, Browns 19 | Browns +10 | ⭐⭐ |
Commanders 23, Falcons 20 | Commanders -1 | ⭐⭐⭐⭐ |
Eagles 26, Buccaneers 20 | Eagles -3.5 | ⭐⭐⭐⭐⭐ |
Patriots 24, Panthers 17 | Patriots -5.5 | ⭐⭐⭐⭐⭐ |
Chargers 27, Giants 17 | Chargers -6.5 | ⭐⭐⭐⭐⭐ |
49ers 24, Jaguars 20 | 49ers -3 | ⭐⭐⭐⭐ |
Rams 26, Colts 23 | Colts +3.5 | ⭐⭐⭐ |
Raiders 20, Bears 17 | Raiders -1 | ⭐⭐ |
Chiefs 27, Ravens 24 | Chiefs +2.5 | ⭐⭐⭐ |
Cowboys 27, Packers 23 | Cowboys +6.5 | ⭐⭐⭐⭐ |
Dolphins 24, Jets 20 | Dolphins -2.5 | ⭐⭐⭐⭐ |
Broncos 26, Bengals 17 | Broncos -7.5 | ⭐⭐⭐⭐ |

🟢 Seahawks (-1) at Cardinals

🚨 Seahawks vs. Cardinals projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Seahawks | 3 | 10 | 7 | 3 | 23 |
Cardinals | 7 | 3 | 3 | 7 | 20 |
🔢 Seahawks projected stats
- Passing leader: Sam Darnold – 22/34, 247 yards, 1 TD, 1 INT
- Rushing leader: Kenneth Walker III – 19 rushes, 88 yards, 1 TD
- Receiving leader: Jaxon Smith-Njigba – 6 receptions, 76 yards, 1 TD
🔢 Cardinals projected stats
- Passing leader: Kyler Murray – 24/36, 264 yards, 2 TD, 1 INT
- Rushing leader: Trey Benson – 17 rushes, 67 yards
- Receiving leader: Marvin Harrison Jr. – 7 receptions, 98 yards, 1 TD
🔮 Seahawks vs. Cardinals prediction
Seattle’s front does just enough on early downs to keep Arizona behind the sticks, which lets the Seahawks live in their nickel looks and rally to short throws. Offensively, they lean on Kenneth Walker and the play-action quick game to stay on schedule.
Arizona’s counter is Kyler Murray to Marvin Harrison Jr. on crossers and Trey McBride on seams, but with James Conner out and Trey Benson stepping in, they’re a touch lighter in short-yardage. Red-zone execution is the difference: Seattle finishes one more drive to win it.
🐂 Texans (-7) vs. Titans

🚨 Titans vs. Texans projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Titans | 0 | 6 | 0 | 7 | 13 |
Texans | 7 | 10 | 3 | 4 | 24 |
🔢 Titans projected stats
- Passing leader: Cam Ward – 21/34, 223 yards, 1 TD, 1 INT
- Rushing leader: Tony Pollard – 12 rushes, 46 yards
- Receiving leader: Calvin Ridley – 7 receptions, 81 yards, 1 TD
🔢 Texans projected stats
- Passing leader: C.J. Stroud – 25/37, 289 yards, 2 TD
- Rushing leader: Nick Chubb – 15 rushes, 64 yards
- Receiving leader: Nico Collins – 6 receptions, 92 yards, 1 TD
🔮 Titans vs. Texans prediction
Houston gets a cleaner pocket than they’ve had, and C.J. Stroud works the middle to Dalton Schultz and digs to Nico Collins. With Tank Dell still out and Christian Kirk in a high-volume slot role, it’s more chain-moving than explosive, but that fits the matchup.
Tennessee’s rookie QB Cam Ward battles, yet protection and penalties show up on long downs. If Houston wins early downs and avoids self-inflicted sacks, they control possession and field position.
🦅 Eagles (-3.5) at Buccaneers

🚨 Eagles vs. Buccaneers projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Eagles | 7 | 6 | 7 | 6 | 26 |
Buccaneers | 3 | 7 | 3 | 7 | 20 |
🔢 Eagles projected stats
- Passing leader: Jalen Hurts – 21/32, 234 yards, 1 TD; 8 rushes, 36 yards
- Rushing leader: Saquon Barkley – 18 rushes, 84 yards, 1 TD
- Receiving leader: A.J. Brown – 7 receptions, 91 yards
🔢 Buccaneers projected stats
- Passing leader: Baker Mayfield – 23/35, 241 yards, 1 TD, 1 INT
- Rushing leader: Bucky Irving – 14 rushes, 59 yards, 1 TD
- Receiving leader: Chris Godwin Jr. – 6 receptions, 74 yards, 1 TD
🔮 Eagles vs. Buccaneers prediction
The Bucs’ OL is patchworked and Mike Evans is trending out, so Tampa’s pass game leans on quick hitters to rookie Emeka Egbuka and veteran Chris Godwin in his return. Philly’s front squeezes the pocket and forces checkdowns; Jalen Hurts answers with steady, efficient drives and a healthy dose of Saquon Barkley.
Even with Nolan Smith Jr. on IR, the Eagles’ trench edge remains meaningful. If Tristan Wirfs plays, it helps, but Philadelphia’s balance and red-zone execution tilt it late.
🪖 Patriots (-5.5) vs. Panthers

🚨 Panthers vs. Patriots projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Panthers | 3 | 7 | 0 | 7 | 17 |
Patriots | 7 | 3 | 7 | 7 | 24 |
🔢 Panthers projected stats
- Passing leader: Bryce Young – 20/31, 208 yards, 1 TD
- Rushing leader: Chuba Hubbard – 15 rushes, 61 yards, 1 TD
- Receiving leader: Hunter Renfrow – 5 receptions, 66 yards
🔢 Patriots projected stats
- Passing leader: Drake Maye – 19/30, 226 yards, 2 TD
- Rushing leader: Rhamondre Stevenson – 17 rushes, 79 yards, 1 TD
- Receiving leader: Stefon Diggs – 6 receptions, 82 yards, 1 TD
🔮 Panthers vs. Patriots prediction
Carolina’s wideout room is banged up (Xavier Legette and Tetairoa McMillan have been on the injury report), so the offense funnels through Chuba Hubbard, quick game to the slot, and play-action shots sparingly. New England’s secondary could get a lift if Christian Gonzalez returns, which tightens windows outside.
Drake Maye benefits from a manageable script: run game on schedule, Hunter Henry and Stefon Diggs on third down, and a couple explosives off play-action. If the Pats protect adequately, they control a low-variance game at home.
⚡️ Chargers (-6.5) at Giants

🚨 Chargers vs. Giants projected score
Team | 1Q | 2Q | 3Q | 4Q | Final |
---|---|---|---|---|---|
Chargers | 10 | 7 | 3 | 7 | 27 |
Giants | 3 | 7 | 0 | 7 | 17 |
🔢 Chargers projected stats
- Passing leader: Justin Herbert – 24/36, 274 yards, 2 TD
- Rushing leader: Omarion Hampton – 13 rushes, 58 yards, 1 TD
- Receiving leader: Keenan Allen – 8 receptions, 96 yards, 1 TD
🔢 Giants projected stats
- Passing leader: Jaxson Dart – 21/33, 218 yards, 1 TD, 1 INT
- Rushing leader: Cam Skattebo – 14 rushes, 63 yards, 1 TD
- Receiving leader: Malik Nabers – 6 receptions, 71 yards, 1 TD
🔮 Chargers vs. Giants prediction
Khalil Mack is on IR, but Los Angeles still gets home with simulated pressures and coverage rotations that discourage deep shots. On offense, Justin Herbert works the perimeter to Keenan Allen and Ladd McConkey and lets rookie rusher Omarion Hampton salt the game late.
New York’s run game is thin with Tyrone Tracy Jr. out and they’re juggling kicker options with Graham Gano sidelined, which hurts finishing drives. If Malik Nabers plays through the shoulder, he’s productive - but the Chargers’ efficiency on third down is the separator.
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