49ers vs. Eagles AI Picks for Wild Card Weekend: NFL Playoff Predictions & Projected Stats

The defending champions open their postseason run today when the Philadelphia Eagles (11-6) host the San Francisco 49ers (12-5) at 4:30 p.m. ET (FOX), and our Eagles vs. 49ers AI picks side with the home favorites to win ugly at Lincoln Financial Field to advance on NFL Wild Card Weekend.

We've trained the latest ChatGPT model to offer its exact score prediction and projected stat leaders for both teams, as well as its best player prop pick today. To be clear, these picks are intended as fun entertainment - you can catch all of our expert picks (from actual humans) with our NFL playoff predictions ahead of the Wild Card Round.

🤖 49ers vs. Eagles AI picks: NFL Wild Card Weekend

See all of our NFL AI predictions with projected scores for every wild-card game.

🔢 Eagles projected stats

• Passing leader: Jalen Hurts — 24/35, 276 yards, 2 TD, 1 INT
• Rushing leader: Saquon Barkley — 17 carries, 82 yards, 1 TD
• Receiving leader: DeVonta Smith — 7 receptions, 96 yards, 1 TD

🔢 49ers projected stats

• Passing leader: Brock Purdy — 21/32, 242 yards, 1 TD, 1 INT
• Rushing leader: Christian McCaffrey — 18 carries, 93 yards, 1 TD
• Receiving leader: Jauan Jennings — 6 receptions, 78 yards

🔮 49ers vs. Eagles prediction

The Eagles closed the season with playoff seeding in hand and have continuity in both phases, led by Jalen Hurts, who limited turnovers and delivered in key moments in 2025. Saquon Barkley’s ability to force defenders into run conflict helps open intermediate passing windows for star receivers DeVonta Smith and A.J. Brown, and that balance is critical against a San Francisco defense that ranks lower in pass rush productivity and points allowed than many expect.

San Francisco’s best offensive weapon is Christian McCaffrey, who nearly finished with 1,000 yards rushing and receiving for the second time in his career. Brock Purdy tends to thrive when McCaffrey forces defenders into conflict, but Purdy’s shoulder stinger and the 49ers’ overall struggles protecting the quarterback late in the season temper their upside. Meanwhile, Philly’s defense has shown the ability to limit explosive plays and make critical stops when it matters most. In a tight, emotionally charged playoff battle, the Eagles’ balanced attack and home-field comfort allow them to eke out a one-score win.

Score prediction: Eagles 27, 49ers 20

🤖 49ers vs. Eagles player prop pick

See the latest NFL odds and our (human) experts' NFL picks for every wild-card game.

⬆️ Saquon Barkley Over 79.5 rushing yards

This matchup favors Barkley because Philadelphia’s offense is built to lean on him in high-leverage games, especially against defenses that want to control the middle of the field. San Francisco’s front is disciplined but has been more vulnerable to gap-sound rushing attacks that force linebackers into run-pass conflict, and Barkley’s burst and patience are critical to keeping the Eagles on schedule early.

The projected game script also supports steady rushing volume. With the Eagles expected to play from ahead or within one score throughout, Barkley should see consistent carries across all four quarters, including late-game usage to protect a lead. Even if Hurts is productive through the air, Philadelphia’s preference to close games on the ground gives Barkley a strong path to clearing this number without needing a breakaway run.

Best prop pick: Saquon Barkley Over 79.5 rushing yards

📺 How to watch 49ers vs. Eagles: NFL Wild Card Weekend

• Date: Sunday, Jan. 11
• Kickoff: 4:30 p.m. ET
• Location: Lincoln Financial Field (Philadelphia)
• TV: FOX