Prairie View A&M vs. Missouri Prediction & Odds: College Basketball Betting Preview for Nov. 17

Our Prairie View A&M vs. Missouri prediction sees the Tigers returning to the floor for another blood-donor matchup after handling Big Ten foe Minnesota on Wednesday.

Even with the rotation still light due to several injuries, the lack of depth shouldn’t be much of a concern for Missouri in this matchup - but could those limitations make this lopsided spread too large a mountain to climb? It’s unlikely, given the sheer offensive mismatch. The action for Prairie View A&M vs. Missouri tips off from Mizzou Arena in Columbia, Mo., tonight at 8 p.m. ET (SEC Network+). Missouri is a 35.5-point betting favorite.

✅ Prairie View A&M vs. Missouri prediction & expert picks

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🏀 Prairie View A&M vs. Missouri preview & score prediction

This margin is gigantic considering that, against SEMO (KenPom: 246), Missouri was favored by 25.5 points and went down to the wire in a five-point victory. As a 7-point favorite against Minnesota (KenPom: 86), the Tigers trailed 46-45 several minutes into the second half before blitzing the Golden Gophers with a 28-4 run to pull away in an 83-60 rout.

Ultimately, the Tigers do have some issues with rebounding and defensive consistency, but they also have otherworldly athleticism and scoring ability to overcome those issues against most opponents. That's what happened against VMI last Sunday in a 106-68 win that would have covered this spread.

Fortunately for Monday’s game, Prairie View A&M doesn’t really pose a threat to capitalize on Missouri’s shortcomings, so we're picking the Tigers to cover this 35.5-point spread.

Prairie View A&M does, uh, nothing particularly well

Prairie View A&M ranks 346th in KenPom's adjusted offensive efficiency and has the 360th-ranked total rebounding percentage out of 364 Division I teams. Those realities negate anything Missouri does poorly, while Missouri's 10th-ranked adjusted offensive efficiency should be a sight to behold against the Panthers' defense, which ranks outside the top 300 in adjusted defense.

FanDuel offers the best odds on Missouri -35.5 (-110). The implied probability at those odds is 52.38%, and the profit on a $10 bet would be $9.09.

Score prediction: Missouri 103, Prairie View A&M 65

🆚 Prairie View A&M vs. Missouri matchup to watch

Missouri’s offense vs. Prairie View A&M’s tempo

Missouri only has an adjusted tempo that ranks 159th in the country, but the Tigers’ modus operandi under Dennis Gates has consistently been to play in transition at a lightning-quick pace.

The Tigers run into trouble when an opponent can effectively slow them down and force them into half-court offense, which often looks more disjointed than when Missouri is able to get out and run.

It actually serves Missouri’s benefit that Prairie View A&M has an adjusted tempo ranking 39th-fastest in the country. This style will play right into Missouri’s strengths and should vault the Tigers to their second instance of 100+ points in the past three games.

Best prop bet: Missouri team total Over 100.5 (-114 via FanDuel)

For more NCAAM picks worth tailing, check out Mike Spector's college basketball best bets tonight.

📊 Prairie View A&M vs. Missouri odds

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📺 How to watch Prairie View A&M vs. Missouri

• Date: Monday, Nov. 17
• Tipoff: 8 p.m. ET
• Location: Mizzou Arena
• TV: SEC Network+