🏀 March Madness Predictions Thursday: Expert Picks & Odds for Sweet 16

Get expert March Madness predictions for Thursday's Sweet 16 slate of the 2026 NCAA Tournament, with picks and best bets.
Houston's Chris Cenac Jr. leads the Cougars in one of four games covered in our March Madness predictions for Thursday.
Pictured: Houston's Chris Cenac Jr. leads the Cougars in one of four games covered in our March Madness predictions for Thursday. Photo by Alonzo Adams-Imagn Images.
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The first set of Sweet 16 games tips off tonight, with No. 2 seed Purdue and No. 11 seed Texas starting the action at 7:10 p.m. ET, and our March Madness predictions for Thursday breakdown all four games on the slate.

With four Elite Eight berths on the line tonight, our March Madness bracket predictions expect at least two underdogs to keep it close in the third round of the NCAA Tournament.


🕒 Thursday's March Madness schedule

Today's Sweet 16 slate:

Favorite Underdog Time Location
(2) Purdue -7.5 (11) Texas 7:10 p.m. ET SAP Center at San Jose (San Jose, Calif.)
(4) Nebraska -1.5 (9) Iowa 7:30 p.m. ET Toyota Center (Houston)
(1) Arizona -8.5 (4) Arkansas 9:45 p.m. ET SAP Center at San Jose (San Jose, Calif.)
(2) Houston -3.5 (3) Illinois 10:05 p.m. ET Toyota Center (Houston)

🔎 March Madness predictions: Thursday's Sweet 16

Check out the latest March Madness odds and Final Four odds.

Texas vs. Purdue odds & predictions

Texas vs. Purdue prediction: Purdue -6.5 

"Purdue is D-I’s most efficient offense and figures to have several advantages over a Longhorns defense that allowed 88.8 points per game in losses during a late-season 1-5 stretch. It’s also hard to overlook that Purdue returned 86% of its scoring from last year’s Sweet 16 team." - via Mike Spector

Iowa vs. Nebraska odds & predictions

Iowa vs. Nerbaska prediction: First half Under 63.5

"These two teams have already played twice, averaging 58.5 total points in the first half. They should be plenty familiar with each other in the third installment, particularly since they last faced off in the regular-season finale on March 8." - via Shane Thurston

Arkansas vs. Arizona odds & predictions

Arkansas vs. Arizona prediction: Arkansas +8.5

"Arizona’s physical dominance was on display in its win over Utah State, as it outrebounded the Aggies 54-to-26 and attempted 28 more free throws. But pessimists will say the Wildcats should’ve won by more than 12 given those disparities, and Utah State even had the game within five points late." - via Mike Spector

Illinois vs. Houston odds & predictions

Illinois vs. Houston prediction: Illinois +3.5

"The battle of the game is Illinois' No. 2 adjusted offensive efficiency against Houston's No. 4 adjusted defensive efficiency. A big thing working in the Fighting Illini's favor is their ability to create extra chances. Their offensive rebound rate of 39.2% ranks third in the country, while Houston's defensive rebounding (30.1%) is slightly below the national average." - via Shane Thurston


🏀 March Madness game predictions: Sweet 16

See all of our experts' college basketball picks based on the latest college basketball odds; picks rated on a 1-to-5 star confidence scale based on betting value.

East Region West Region South Region Midwest Region
St. John's vs. Duke (3/27) Texas vs. Purdue (3/26) Iowa vs. Nebraska (3/26) Alabama vs. Michigan (3/27)
Michigan State vs. UConn (3/27) Arkansas vs. Arizona (3/26) Illinois vs. Houston (3/26) Tennessee vs. Iowa State (3/27)

📅 March Madness key dates

  • Selection Sunday: March 15
  • First Four: March 17-18 (Dayton, Ohio)
  • First round: March 19-20
  • Second round: March 21-22
  • Sweet 16: March 26-27
  • Elite Eight: March 28-29
  • Final Four: Saturday, April 4
  • National championship game: Monday, April 6

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