Cincinnati vs. Clemson Predictions & Odds: College Basketball Picks Today (Dec. 21)
Last Updated: December 21, 2025 9:43 AM EST • 2 minute read X Social Google News Link
It’s time for my Cincinnati vs. Clemson predictions before a matinee matchup at 3 p.m. ET on Sunday at Bon Secours Wellness Arena in Greenville, S.C. (ESPN).
The Tigers (9-3) are a 6-point betting favorite against the Bearcats (7-4) in what could be a low-scoring matchup. The total is 141.5, and all signs point toward an Under based on how both teams are playing right now.
🏀 Cincinnati vs. Clemson prediction
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Under 141.5 (-110 via Caesars) ⭐⭐⭐⭐
It’s difficult to imagine the Bearcats finding much offensive success in this one. They rank 229th in offensive efficiency and 287th in 3-point shooting. Those are putrid numbers for a power conference team.
At the same time, Clemson is elite on the defensive end. The Tigers are the fourth-best team in the country at defending the 3-point line. They are also 33rd in adjusted defensive efficiency.
Clemson would love to win a rock fight, so I like the Under at 141.5 at Caesars.
Score prediction: Clemson 71, Cincinnati 66
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RJ Godfrey, F, Clemson: Under 1.5 assists (+130) ⭐⭐⭐
Clemson forward RJ Godfrey was limited to 13 minutes last time out against South Carolina due to foul trouble. He finished with six points, three rebounds, and zero assists.
Godfrey’s offensive impact has been minimal in back-to-back games. He has 15 points (on 12 shots) and one assist over the past two contests. He’s failed to clear this assist prop in three of his previous five matchups.
Given that I project a defensive battle, I like the +130 price on Under 1.5 assists for Godfrey, which would net $13 on a $10 wager at BetMGM.
📊 Cincinnati vs. Clemson odds
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📺 How to watch Cincinnati vs. Clemson
- Date: Sunday, Dec. 21
- Tipoff: 3 p.m. ET
- Location: Bon Secours Wellness Arena (Greenville, S.C.)
- TV: ESPN
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