Rays vs. Guardians Prediction, Odds & Best Bets: Cleveland Can Stop Slide

The Guardians have Tanner Bibee on the mound tonight, who has been effective at home this season.

Shane Jackson

Last Updated: August 25, 2025 11:21 AM EDT • 3 minute read

Rays vs. Guardians Prediction, Odds & Best Bets: Monday, Aug. 25 — Pictured: Cleveland Guardians pitcher Tanner Bibee celebrates as I offer my Rays vs. Guardians prediction. Photo by Mark J. Rebilas via Imagn Images.

The Cleveland Guardians (64-65) aim to end a five-game skid when they host the Tampa Bay Rays (63-67), and I'm breaking down the matchup with my Rays vs. Guardians prediction. First pitch is at 6:40 p.m. ET on Monday at Progressive Field (FDSN SUN, CLEG, FS1).

Cleveland is a -120 favorite to stop the slide at the best sports betting sites, which is a line I’m willing to take. There is a starting pitcher mismatch between Ian Seymour and Tanner Bibee (particularly at home) for my Rays vs. Guardians best bets.

⚾ Rays vs. Guardians prediction & odds

🔎 Our NEW MLB player prop odds tool can help you find the best MLB odds to make your MLB picks.

💰 Rays vs. Guardians prediction & best bet

✅ Rays vs. Guardians prediction: Guardians to win (-120 via FanDuel)

Bet $5, Win $300 in Bonus Bets

New customers only. Min. first deposit and wager of $5+. Bonus bets are awarded within 72 hours of winning your first wager. T&Cs apply.

Claim $300

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

As I make my Rays vs. Guardians prediction, I’m surprised that this line is available. Ballpark Pal’s model projects a 58.7% chance of victory for the Guardians, giving them fair odds of -142.

Seymour, a reliever, slides into the starting rotation due to injury. He’s made 12 appearances this season, posting a 3.86 ERA. He’s yet to pitch more than 3 1/3 innings in 2025, giving up eight runs on nine hits over his last two games.

Tanner Bibee (9-9, 4.62 ERA) has taken a step back in his third season, but he’s been much better at home.

He has a 3.19 ERA in 10 home starts this year compared to a 5.64 clip on the road. I’ll back him at these odds, where a $10 bet nets a $8.33 profit.

📊 Live Rays vs. Guardians odds: Monday, 6:40 p.m. ET

💰 Best Rays vs. Guardians player prop

✅ Best Rays vs. Guardians player prop: David Fry Under 0.5 hits (+115 via ESPN BET)

Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

My best Rays vs. Guardians player prop might be more available when lineups are announced, but I’m interested in fading David Fry as a pinch-hit risk in tonight’s matchup. He’s gotten the start in six straight matchups against left-handed pitchers, but he’s exited the game early in half of those contests.

Those chances are even higher in this spot, considering Seymour might not last more than one or two times through the order. Fry hasn’t recorded a hit since Aug. 14, so I don’t mind a plus-money price on that trend continuing on Monday.

💡 Expert MLB predictions today

❓MLB betting FAQs

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written by:
Shane Jackson

Shane Jackson has been writing for Sportsbook Review since 2022, though his passion for sports, writing, and betting runs much longer than that. He graduated from the University of Kansas with a journalism degree in 2017 and has been covering sports ever since, working for MLB.com, Manhattan Mercury, Lawrence Journal-World, WynnBET, Bet Chicago Sports, BetNOLA, and BetMGM. Jackson cares about creating quality sports betting content above all else. He uses a mixture of models, information, film, analysis, and a top-down approach to locate every best bet shared for SBR. He never gives out a pick that he wouldn’t be willing to spend his own money on. Jackson is focused on finding +EV bets on a daily basis for a variety of sports such as NCAAF, NCAAB, NFL, NBA, WNBA, and MLB. He usually bets on props but is willing to wager on a spread or total when there is an edge. Don’t ask him how many bets he has placed on a typical college football Saturday. Jackson doesn’t care if you follow him on social media, but his Twitter account has info on how you can follow his bets through multiple third-party platforms. He just wants you to read all the great work from the SBR team.