Padres vs. Mariners Prediction, Betting Odds & MLB Expert Picks Today: Aug. 27

Last Updated: August 27, 2025 1:39 PM EDT • 4 minute read X Social Google News Link

The series victory between the San Diego Padres (75-58) and Seattle Mariners (71-62) is up for grabs Wednesday afternoon as I make my Padres vs. Mariners prediction. The action is set to begin at 4:10 p.m. ET on Wednesday at T-Mobile Park in Seattle (MLBN).
Seattle is a -135 favorite to win the rubber match. I plan to side with the home team at that price as part of today’s MLB picks.
I'm also targeting Josh Naylor’s strikeout prop, while Gabe Henderson is eyeing Cal Raleigh in the best home run predictions today.
📊 Padres vs. Mariners odds: Aug. 27
MLB odds update live in real time.
👀 Padres vs. Mariners betting odds analysis
The Mariners began as a -140 favorite at the best sports betting sites and largely remained there as of Wednesday afternoon. BetMGM (-135) offers slightly better odds on Seattle to win the series finale on Wednesday. The Mariners have won four of five head-to-head matchups against San Diego this season.
⚾ Padres vs. Mariners expert picks
MLB expert picks made Wednesday; odds subject to change.
- Moneyline pick: Mariners (-135 via BetMGM) ⭐⭐⭐⭐
- Run line pick: Mariners -1.5 (+155 via BetMGM) ⭐⭐
- Over/Under pick: Over 7.5 (-125 via Caesars) ⭐⭐⭐

🔮 Padres vs. Mariners prediction & best bet
Track the latest MLB scores for line movement and matchup info.
🔱 Mariners to win (-135) ⭐⭐⭐⭐

If you believe in the Mariners on Wednesday, I think there are two different ways to bet on them in the finale. I like their moneyline odds (-135 at BetMGM) as a four-star play, as well as the Over on their team total of 3.5 (-143 at Caesars).
THE BAT X’s model projects a fair price of -154 for Seattle’s moneyline price tag with Bryan Woo on the mound. Woo has spun a 2.08 ERA in four starts this month, allowing one run or fewer in three different outings.
Seattle could also score a bit on San Diego, which has had to use eight relievers over the last two games. Ballpark Pal projects 4.35 runs for the Mariners, who have averaged six runs in their five meetings with the Padres this season. Seattle has scored 15 runs in this midweek series.
A $10 bet on both options nets a solid payout, earning $7.41 on the moneyline wager (57.45% implied probability) and $6.99 on Seattle’s team total (58.85% implied probability).
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💰 Best Padres vs. Mariners player prop bet
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬇️ Josh Naylor Under 0.5 hitter strikeouts (-105) ⭐⭐⭐⭐

First baseman Josh Naylor has a strikeout rate of 20.9% since being traded to Seattle, well above his career average of 16.1%. It supports the theory that the batter’s eye at T-Mobile Park has an impact on hitters.
However, this is a good spot for Naylor to finish with no strikeouts. He will face San Diego right-hander Yu Darvish, who doesn’t whiff leftys (17.7% strikeout rate) as much as he does rightys (27.2%).
Naylor only has two strikeouts in his previous eight games, so I’ll take this -105 value to net a $9.52 profit on a $10 bet.
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🚑 Padres vs. Mariners injuries
📺 Padres vs. Mariners game info
- When: Wednesday, Aug. 27
- Kickoff: 4:10 p.m. ET
- Where: T-Mobile Park
- How to watch: MLBN
💡 Expert MLB predictions today
- MLB home run predictions
- Nationals vs. Yankees prediction
- Rays vs. Guardians prediction
- Padres vs. Mariners prediction
❓ MLB betting FAQs
How do betting odds work?
Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.
What is the run line in baseball?
The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.
What does moneyline mean in betting?
The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.
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