Best Padres vs. Cubs Player Prop Picks for NL Wild-Card Round Game 2
The San Diego and Chicago Cubs square off in an intriguing postseason matchup, and I’m breaking it down with my best Padres vs. Cubs player props for NL Wild-Card Game 2.
The Cubs are the -111 moneyline betting favorite and ascended the World Series odds after their Game 1 victory.
My MLB picks for Game 2 fade Padres right-hander Dylan Cease, while expecting solid days at the plate from Fernando Tatis Jr. and Michael Busch.
First pitch is set for 3:08 p.m. ET from Wrigley Field in Chicago (ABC).
⚾ Best Padres vs. Cubs player props
MLB player prop bets for NL Wild-Card Round Game 2; odds subject to change.
- Fernando Tatis Jr. Over 1.5 hits, runs, and RBIs (-110 via DraftKings) ⭐⭐⭐
- Dylan Cease Over 3.5 hits allowed (-134 via DraftKings) ⭐⭐⭐
- Michael Busch Over 1.5 hits, runs, and RBIs (+121 via DraftKings) ⭐⭐⭐
📺️ How to watch Padres vs. Cubs
When: Wednesday, Oct. 1 @ 3:08 p.m. ET
Where: Wrigley Field (Chicago)
TV: ABC
💰 Best Padres vs. Cubs player prop picks
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
⬆️ Fernando Tatis Jr. Over 1.5 hits, runs, and RBIs (-110) ⭐⭐⭐
Tatis was quiet in Game 1, but I don't expect that to continue in a win-or-go-home situation.
Tatis closed the season on a heater at the plate, hitting .321 with 15 runs, five home runs, and nine RBIs over the last 15 games. The superstar outfielder is a notorious postseason performer, with a career 1.231 OPS and six home runs in 14 contests.
A $10 bet on Tatis’ Over yields a profit of $9.09 at DraftKings, and the -110 odds have an implied probability of 52.38%.
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🥶 Dylan Cease Over 3.5 hits allowed (-134) ⭐⭐⭐⭐
Cease allowed fewer than four hits in just seven of his 32 starts in 2025. He also struggled mightily on the road, posting a 1-9 record with a 5.58 ERA and 76 hits allowed in 80 2/3 innings.
And he allowed seven hits over 5 ⅔ innings in a home start against the Cubs back in April. The Padres likely won’t have Cease on a long leash facing elimination with a deep bullpen. Despite that, I think the Cubs will make life tough on him for however long he’s in the game.
A $10 wager on Cease to allow at least four hits would provide a profit of $7.46 and has an implied probability of 57.26%.
🔥 Michael Busch Over 1.5 hits, runs, and RBIs (+121) ⭐⭐⭐
Busch didn’t do much at the dish in Chicago’s Game 1 victory. However, he should find some immediate confidence with Cease on the mound.
Both of Busch’s career hits against Cease have gone for home runs, and his success against fastballs and offspeed pitches during the regular season should be an ideal fit against Cease’s heavy dose of fastballs and sliders.
A $10 winning wager on Busch’s Over would provide a profit of $12.10, and the implied probability of the +121 odds is 45.25%.
📊 Padres vs. Cubs odds
Latest MLB odds updated live in real time.
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