Mets vs. Padres Prediction, Odds & Best Bets: The Magic of Petco Park

San Diego has been superb at home this season, but oddsmakers believe New York can overcome its road struggles and rebound tonight.

Gabe Henderson

Last Updated: July 29, 2025 4:09 PM EDT • 4 minute read

Mets vs. Padres Prediction, Odds & Best Bets: Tuesday, July 29 — Pictured: San Diego Padres first baseman Luis Arraez (4) celebrates as we make our Mets vs. Padres prediction. Photo by Denis Poroy via Imagn Images.

San Diego snapped New York's winning streak in a 7-6 thriller to open the series, and my Mets vs. Padres prediction expects the hosts to win a second straight NL showdown tonight.

First pitch from Petco Park in San Diego is scheduled for 9:40 p.m. ET (MLB Network). The best sports betting sites list the Mets as -126 betting favorites with a total set at O/U 8.5 runs.

My Mets vs. Padres best bets feature a familiar face as I back the hosts to extend their winning streak at home in San Diego.

Mets vs. Padres prediction: Padres to win (+110 via bet365) ⭐⭐⭐
Best Mets vs. Padres player props: Luis Arraez at least 2 hits (+200 via FanDuel) ⭐⭐⭐

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✅ Mets vs. Padres prediction: Padres to win (+110 via bet365)

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My Mets vs. Padres prediction for the series opener rambled on at nauseam about the importance of San Diego playing this series at Petco Park. The venue proved to be the difference in the end, with Elias Diaz's two-out hit in the home half of the ninth inning sending Padres fans home happy.

The walk-off win elevated San Diego to 32-18 on the season at home, one of the best tallies in baseball. Meanwhile, it ended the Mets' road winning streak and sunk them to 25-29 away from Citi Field. Tonight the visitors turn to Sean Manaea, who's making his third start this season, in an attempt to remedy this issue.

Monday night's victory makes it three wins on the bounce for the Padres and four of the last five at home. My Mets vs. Padres best bet sides with San Diego to get the job done again behind spot starter Ryan Bergert (2.84 ERA). The underdogs' +110 betting odds carry a 47.62% implied probability at the best sports betting apps.

💰 Best Mets vs. Padres player props

✅ Best Mets vs. Padres player prop: Luis Arraez at least 2 hits (+200 via FanDuel)

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If you tailed my best Mets vs. Padres player prop in the series opener, I have two things to say to you.

Firstly, yes, I am a Luis Arraez stan. I will defend batting average as an overhated stat until the day Rob Manfred decides to abolish scorekeeping in favor of leaguewide Banana Ball.

Second, you're welcome for the winning plus-money pick.

Before you ask - or judge - yes, I'm returning to the Arraez pool for the third time in a week.

The base-knock machine posted his second consecutive multi-hit performance on Monday, and what do you know? He's got stellar stats against tonight's starter, as well. Arraez has a .444 batting average (4-for-9 with three singles, one home run) against Manaea.

BetMGM once again offers the best odds among the best sportsbooks. Arraez's two-plus hits prop is trading at +200, meaning a $10 bet profits $20 if the infielder extends his two-game multi-hit streak.

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❓MLB betting FAQs

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.